Abstract:
:PEC-60, a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor, has been isolated, characterized and molecularly cloned. It shows biological activity as a hormone in both the gastrointestinal tract and in the immune system. We now report immunohistochemical evidence suggesting its neural localization exclusively within central and peripheral catecholamine (CA) neurones. PEC-60-like immunoreactivity was present in cell bodies, dendrites and nerve terminals of virtually all catecholamine neurones examined and including the noradrenergic gland cells of the adrenal medulla. PEC-60-like immunoreactivity was not seen, however, within the tyrosine hydroxylase-positive but CA-negative arcuate neurones producing growth hormone releasing hormone. The findings open up the possibility that a PEC-60-like peptide may represent a generalized co-transmitter in the peripheral and central CA neurones.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Fuxe K,Tinner B,Metsis M,Staines W,Morassutti D,Agnati LF,Ostensson CG,Efendic S,Agerberth B,Goldstein Mdoi
10.1097/00001756-199409080-00033subject
Has Abstract,Author List Incompletepub_date
1994-09-08 00:00:00pages
1817-21issue
14eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Human cognitive decisions can be strongly susceptible to the manner in which options are presented ('framing effect'). Here we investigated the neural basis of response adjustments induced by changing frames during intuitive decisions. Evidence exists that the anterior cingulate cortex plays a general role in behavior...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282202c61
更新日期:2007-07-16 00:00:00
abstract::We investigated the effect of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine on eyeblink conditioning in glutamate receptor subunit 62 null mice, which have severe impairments in cerebellar long-term depression (LTD). Mice were injected intraperitoneally with scopolamine (0.5 mg/kg) or saline, an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00036
更新日期:2002-01-21 00:00:00
abstract::We previously reported that the methanol extract of Ashwagandha (roots of Dunal) induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells. Double immunostaining ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200210070-00005
更新日期:2002-10-07 00:00:00
abstract::Amyotrophic lateral sclerosis is an incurable disease in which cerebral and spinal motoneurons degenerate, causing paralysis and death within 2-5 years. One of the pathogenic factors of motoneuron death is a chronic excess of glutamate, which exceeds its removal by astrocytes, i.e. excitotoxicity. Extra glutamate upta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310270-00017
更新日期:2003-10-27 00:00:00
abstract::We investigated the age-related change in the distribution of a molecular marker for neural stem and precursor cells, Musashi-1, in the olfactory epithelium of mice from 1 day up to 16 months of age using immunohistochemistry. We also compared the distribution pattern of Musashi-1 with that of growth-associated protei...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280bef7e2
更新日期:2007-05-07 00:00:00
abstract::Adenosine has an anticonvulsant effect in various models of epilepsy. This effect appears to be mediated through the activation of adenosine A1 receptors (A1Rs). We immunohistochemically investigated the changes of A1Rs expression in kainate-treated and hippocampus-kindled rats as chronic models of epilepsy. In the no...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00014
更新日期:1999-11-26 00:00:00
abstract::Beta-N-methylamino-L-alanine (BMAA) is a nonprotein amino acid that may be involved in neurodegenerative diseases. It is produced by a large variety of cyanobacteria and is found at high levels in the brains of Alzheimer's disease and amyotrophic lateral sclerosis patients. Although BMAA is clearly a neurotoxin, previ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328333dfd5
更新日期:2010-01-06 00:00:00
abstract::Retinal ganglion cells of the fish have the spontaneous capacity to regenerate after nerve crush, a phenomenon known to be facilitated by nerve growth factor (NGF). We have studied the high-affinity NGF receptor TrkA, during the regeneration of the tench (Tinca tinca L.) optic nerve, using immunocytochemical technique...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810260-00014
更新日期:1998-10-26 00:00:00
abstract::Damage to central nervous system white matter is observed following hypoglycemia, raising the possibility that hypoglycemia influences oligodendrocytes and myelination. To examine effects of hypoglycemia on oligodendrocytes and myelin formation, we studied cultured oligodendrocyte precursor cells and cerebellar slice ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000192733.00535.b6
更新日期:2006-01-23 00:00:00
abstract::Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of ment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000132202.69212.79
更新日期:2004-06-28 00:00:00
abstract::The distribution of activated NF-kappaB (p65) was studied in granule cells of the rat fascia dentata using confocal laser scanning microscopy and preembedding immunogold electron microscopy. Activated NF-kappaB, detected with a monoclonal antibody specific for the nuclear localization signal-epitope, was found in prox...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00036
更新日期:2000-03-20 00:00:00
abstract::Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200302100-00009
更新日期:2003-02-10 00:00:00
abstract::Epilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000208
更新日期:2014-11-12 00:00:00
abstract::Some of the most extensively used fluorophores for multicolour fluorescence labelling of tissue, such as Lucifer yellow, fluorescein, Cyanine-3.18 and rhodamine, all have the disadvantage of being difficult to separate spectrally due to their broad and overlapping emission spectra. With the intensity-modulated multipl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505300-00024
更新日期:1995-05-30 00:00:00
abstract::It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280586839
更新日期:2007-03-26 00:00:00
abstract::Although the self-referential effect was widely supported by several previous studies, there was few event-related potential (ERP) evidence for the encoding mechanism of the self-referential effect. The present study employed ERPs to investigate whether the electrophysiological indices of the encoding processing could...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001303
更新日期:2019-09-04 00:00:00
abstract::We produced NB3C4, a novel monoclonal antibody specific for oligodendrocytes, using human neuroblastoma IMR-32 cells. NB3C4 specifically recognized oligodendrocytes in the CNS, although it bound to neuroblastoma IMR-32 cells and oligodendrocytes in vitro. Double immunofluorescence staining of rat brain using NB3C4 and...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00045
更新日期:2001-02-12 00:00:00
abstract::GPR39, an orphan G protein-coupled receptor, has been recently identified as the receptor for the bioactive peptide obestatin. Obestatin is secreted from the stomach and acts as an anti-appetite hormone. This activity is induced whether obestatin is administered intraperitoneally or intracerebroventricularly. GPR39 is...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000215779.76602.93
更新日期:2006-05-29 00:00:00
abstract::Prepulse inhibition (PPI) of the acoustic startle reflex is a measure of sensorimotor gating which occurs in both rodents and humans. PPI is deficient in severe neuropsychiatric disorders such as schizophrenia. We investigated PPI in 10 adult monkeys (Cebus apella). Stimuli were 115 dB white noise startle pulses, eith...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00031
更新日期:2001-01-22 00:00:00
abstract::Single unit recordings were made from the ventral posterior lateral thalamus of anaesthetized rats to characterize responses to the activation of new receptive fields induced by either local anaesthesia or amputation. Receptive fields confined to single digits were identified and evoked unit responses to the stimulati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Benevolence is widespread in our societies. It is defined as considering a subordinate group nicely but condescendingly, that is, with charity. Deleterious consequences for the target have been reported in the literature. In this experiment, we used functional MRI (fMRI) to identify whether being the target of (sexist...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283625b5b
更新日期:2013-07-10 00:00:00
abstract::Optical imaging of rat barrel cortex has provided detailed spatio-temporal maps of functional cortical architecture. We describe an event-related procedure (ERP) for optical imaging based on selective signal averaging as reported by Burock et al., using an anti-correlative pseudo-random event sequence. The sequence us...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00037
更新日期:2000-07-14 00:00:00
abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002070-00031
更新日期:2000-02-07 00:00:00
abstract::A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00044
更新日期:1998-06-22 00:00:00
abstract::Neuroblastoma is an important problem in children. Long noncoding RNAs (lncRNAs) exhibit important roles in tumorigenicity of neuroblastoma. However, the role and mechanism of lncRNA small nucleolar RNA host gene 16 (SNHG16) in neuroblastoma tumorigenicity remain poorly understood. Forty-six neuroblastoma samples and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001537
更新日期:2020-12-09 00:00:00
abstract::Myelin basic proteins (MBPs) have been shown to be ADP-ribosylated in-vitro by cholera toxin in the presence of NAD. Since acid-soluble extracts of brain contain other proteins in the 14-32 kD range (such as histones) in addition to MBP's, the identification of the ADP-ribosylated proteins was uncertain. To determine ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199011000-00012
更新日期:1990-11-01 00:00:00
abstract::We investigated the effect of an NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), on the levels of endogenous GABA in the rat striatum using in vivo microdialysis. Rats were perfused with the artificial CSF containing L-NMMA (0.1, 0.3 and 1.0 mM) or its inactive isomer D-NMMA (1.0 mM) for 1 h. Infusion of L-N...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507100-00016
更新日期:1995-07-10 00:00:00
abstract::The taste reactivity test was used to evaluate the ability of motion sickness to produce conditioned rejection reactions, a putative measure of nausea in rats. Following three conditioning trials, rats displayed conditioned rejection reactions during an intraoral infusion of a rotation-paired saccharin solution. This ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199905140-00030
更新日期:1999-05-14 00:00:00
abstract::Transcranial direct current stimulation (tDCS) was used in 17 normal individuals to modulate vestibulo-ocular reflex (VOR) and self-motion perception rotational thresholds. The electrodes were applied over the temporoparietal junction bilaterally. Both vestibular nystagmic and perceptual thresholds were increased duri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283646e65
更新日期:2013-10-02 00:00:00
abstract::Prolonged activation of brain N-methyl-D-aspartic acid (NMDA) receptors increases intraneuronal (Ca2+) and nitric oxide (NO) synthesis, and may be responsible for neuronal death in acute brain insults and chronic neurodegenerative diseases. NO can be converted in vitro to toxic hydroxyl (OH) radical. Using microdialys...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199310000-00018
更新日期:1993-10-25 00:00:00