Increased levels of TrkA in the regenerating retinal ganglion cells of fish.

Abstract:

:Retinal ganglion cells of the fish have the spontaneous capacity to regenerate after nerve crush, a phenomenon known to be facilitated by nerve growth factor (NGF). We have studied the high-affinity NGF receptor TrkA, during the regeneration of the tench (Tinca tinca L.) optic nerve, using immunocytochemical techniques. TrkA-like immunoreactivity increased during the regeneration of the retinal ganglion cells. The increase is followed by a change in the subcellular distribution from perinuclear in control cells to cytoplasmic and perinuclear in regenerating ones. This increase was observed when antibodies against the extracellular domain of TrkA were used; no changes in TrkA-like immunoreactivity were observed with antibodies against the intracellular domain of TrkA. We thus conclude that modulation of TrkA is involved in the regeneration of fish retinal ganglion cells.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Vecino E,Caminos E,Becker E,Rudkin BB,Evan GI,Martín-Zanca D

doi

10.1097/00001756-199810260-00014

subject

Has Abstract

pub_date

1998-10-26 00:00:00

pages

3409-13

issue

15

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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