Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.

abstract：:Pharmacological manipulation of brain dopamine concentration affects visuospatial working memory in humans and in animals, the latter effects localized to the prefrontal cortex. However, the effects of dopamine agonists on humans are poorly understood. We hypothesized that bromocriptine would have an effect on cogniti...

journal_title：Neuroreport

authors： Kimberg DY,D'Esposito M,Farah MJ

更新日期：1997-11-10 00:00:00

abstract：:Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...

journal_title：Neuroreport

authors： Root JC,Tuescher O,Cunningham-Bussel A,Pan H,Epstein J,Altemus M,Cloitre M,Goldstein M,Silverman M,Furman D,Ledoux J,McEwen B,Stern E,Silbersweig D

更新日期：2009-03-04 00:00:00

abstract：:The effect of Co-dergocrine (Hydergine) on acetylcholine (ACh) release in the striatum and hippocampus has been studied by means of brain microdialysis and compared to the effect of SKF 38393 and of LY 171555 selective D1 and D2 dopamine (DA) receptor agonists, respectively. Co-dergocrine (1 and 5 mg kg-1 i.p.) as wel...

journal_title：Neuroreport

authors： Imperato A,Obinu MC,Dazzi L,Carta G,Mascia MS,Casu MA,Gessa GL

更新日期：1994-02-24 00:00:00

abstract：:The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but not that produced ...

journal_title：Neuroreport

authors： Eshhar N,Striem S,Biegon A

更新日期：1993-12-13 00:00:00

abstract：:Recent studies of electroencephalogram event-related potentials reported aberrant feedback-related negativity (FRN) in neurological and psychiatric diseases, such as alcoholism and attention-deficit hyperactivity disorder. These diseases are characterized by high impulsivity. We investigated the relationship between F...

journal_title：Neuroreport

authors： Onoda K,Abe S,Yamaguchi S

更新日期：2010-07-14 00:00:00

abstract：:Rap1A, first identified as a suppressor of transformed phenotype induced by an activated ras oncogene, is abundantly expressed in the brain. Its neurophysiological function, however, is poorly understood. When an activated Rap1A mutant (Rap1-12V) or a dominant negative H-Ras mutant (Ras-17N) was expressed in CA1 neuro...

journal_title：Neuroreport

authors： Imamura Y,Matsumoto N,Kondo S,Kitayama H,Noda M

更新日期：2003-07-01 00:00:00

abstract：:The effects of a pharmacological blockade of the periaqueductal grey of the midbrain (PAG) on the elicitability of vocal fold movements from the facial motor cortex on the one hand and the anterior cingulate cortex and dorsomedial hypothalamus on the other were studied in the squirrel monkey. PAG blockade abolished vo...

journal_title：Neuroreport

authors： Jürgens U,Zwirner P

更新日期：1996-11-25 00:00:00

abstract：:Using functional magnetic resonance imaging (fMRI), we investigated whether the response of auditory and visual cortex was modulated by attending selectively to either heard or seen numbers presented simultaneously. Alternating attention between modalities modulated fMRI signal within the corresponding sensory cortex....

journal_title：Neuroreport

authors： Woodruff PW,Benson RR,Bandettini PA,Kwong KK,Howard RJ,Talavage T,Belliveau J,Rosen BR

更新日期：1996-08-12 00:00:00

abstract：:To investigate the origin of high-frequency somatosensory evoked potential (SEP) components, we recorded median nerve SEPs from the scalp and the depth in six monkeys. Laminar field potentials were analyzed in area 3b (N10; corresponding to human N20) and area 1 (P12; corresponding to human P25). After digital filteri...

journal_title：Neuroreport

authors： Shimazu H,Kaji R,Tsujimoto T,Kohara N,Ikeda A,Kimura J,Shibasaki H

更新日期：2000-08-21 00:00:00

abstract：:This study investigated whether mild birth complications (C-section birth, C-section + 15 min global anoxia) interact with stress at adulthood to modulate levels of [3H]WIN 35428 binding to dopamine transporters (DAT) in rat brain. Without stress, adult C-sectioned rats showed increased DAT binding in the dorsal stria...

journal_title：Neuroreport

authors： El-Khodor BF,Boksa P

更新日期：2002-02-11 00:00:00

abstract：:Event-related brain potentials were examined in 6 to 8-year-old children with primary language disorder before and after a 5-week narrative-based language intervention. Participants listened to sentences ending with semantically congruous or incongruous words. By comparison with typical controls, the children with pri...

journal_title：Neuroreport

authors： Popescu M,Fey ME,Lewine JD,Finestack LH,Popescu EA

更新日期：2009-08-05 00:00:00

abstract：:Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma-band bursts (around 40...

journal_title：Neuroreport

authors： Grice SJ,Spratling MW,Karmiloff-Smith A,Halit H,Csibra G,de Haan M,Johnson MH

更新日期：2001-08-28 00:00:00

abstract：:The relationship between cerebral ischemia and Alzheimer's disease has been evaluated extensively. However, the association between cerebral ischemia and the deposition of beta-amyloid (Abeta) remains to be clarified. Here, we used mice bilateral common carotid artery ligation model to investigate the alterations in m...

journal_title：Neuroreport

authors： Ye JT,Pi RB,Mao XX,Chen XH,Qin J,Xu SW,Liu PQ

更新日期：2009-10-28 00:00:00

abstract：:The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...

journal_title：Neuroreport

authors： Mutlukan E

更新日期：1993-09-03 00:00:00

abstract：:The relation between neuronal activity in the superior parietal lobule with working memory capacity in an elderly population was investigated. Using functional magnetic resonance imaging we examined effects associated with the performance of a reading span test and individual differences in executive function and shor...

journal_title：Neuroreport

authors： Otsuka Y,Osaka N,Osaka M

更新日期：2008-09-17 00:00:00

abstract：:The octave illusion is experienced when two simultaneous tones, separated by one octave and presented to the opposite ears, are continuously reversed between the two ears. Subjects consistently report a sequence of alternating single tones: the high tone in the right ear and the low in the left. We wished to determine...

journal_title：Neuroreport

authors： Ross J,Tervaniemi M,Näätänen R

更新日期：1996-12-20 00:00:00

abstract：:Light physiologically regulates the levels of c-Fos in the suprachiasmatic nucleus (SCN), but the identity of most of the cells that express this DNA-binding protein is unknown. To determine whether SCN c-Fos expression is restricted to neurons, we performed light microscopic double-label immunohistochemistry on secti...

journal_title：Neuroreport

authors： Bennett MR,Schwartz WJ

更新日期：1994-09-08 00:00:00

abstract：:Intrinsic circuitry in the barrel cortex has been shown to be readily modifiable in response to changes in the patterns of sensory input, even in adult animals. It is believed that sensory experience modifies synaptic circuits by imposing specific patterns of repetitive presynaptic and postsynaptic coactivity, i.e. by...

journal_title：Neuroreport

authors： Aroniadou-Anderjaska V,Keller A

更新日期：1995-11-27 00:00:00

abstract：:Dopamine plays important functional roles in the vertebrate retina. Here we show that functional D2 dopamine receptors are present on mammalian retinal Müller (glial) cells. Using an antiserum directed to two oligopeptides predicted from rat D2 receptor DNA, patchy label was demonstrated immunocytochemically on virtua...

journal_title：Neuroreport

authors： Biedermann B,Fröhlich E,Grosche J,Wagner HJ,Reichenbach A

更新日期：1995-03-07 00:00:00

abstract：:Neuroblastoma is an important problem in children. Long noncoding RNAs (lncRNAs) exhibit important roles in tumorigenicity of neuroblastoma. However, the role and mechanism of lncRNA small nucleolar RNA host gene 16 (SNHG16) in neuroblastoma tumorigenicity remain poorly understood. Forty-six neuroblastoma samples and ...

journal_title：Neuroreport

authors： Ge Y,Tan S,Bi J,Rao M,Yu Y,Tian L

更新日期：2020-12-09 00:00:00

abstract：:The possible role of endogenous cholinergic innervation in hippocampal plasticity is controversial. We studied the role of acetylcholine (ACh) in short- and long-term potentiation (STP and LTP), using the cholinergic neurotoxin 192 IgG-saporin. It was still possible to induce STP the LTP in the CA1 field following com...

journal_title：Neuroreport

authors： Jouvenceau A,Billard JM,Lamour Y,Dutar P

更新日期：1996-03-22 00:00:00

abstract：:Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased...

journal_title：Neuroreport

authors： Virgos C,Martorell L,Simó JM,Valero J,Figuera L,Joven J,Labad A,Vilella E

更新日期：1999-07-13 00:00:00

abstract：:We examined effects of trial averaging upon spatial extent, spatial topography, and temporal properties of fMRI activation. Two subjects participated in an event-related visual stimulation design. There was an exponential relation between number of trials and spatial extent, such that additional trials identified, on ...

journal_title：Neuroreport

authors： Huettel SA,McCarthy G

更新日期：2001-08-08 00:00:00

abstract：:Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....

journal_title：Neuroreport

authors： Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

更新日期：2007-03-26 00:00:00

abstract：:It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...

journal_title：Neuroreport

authors： Vinader-Caerols C,Collado P,Segovia S,Guillamón A

更新日期：1998-08-03 00:00:00

abstract：:We examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodies which enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate ex...

journal_title：Neuroreport

authors： Bar-Peled O,O'Brien RJ,Morrison JH,Rothstein JD

更新日期：1999-03-17 00:00:00

abstract：:Using subtractive cloning, we identified a 1.4 kb mRNA that was ubiquitously expressed in various tissues; this mRNA was highly up-regulated in amygdala nuclei in mice when morphine was repeatedly administered but not when an opiate-receptor antagonist was co-administered. The mRNA encodes a 23 kDa protein, designated...

journal_title：Neuroreport

authors： Ikemoto MJ,Inoue K,Akiduki S,Osugi T,Imamura T,Ishida N,Ohtomi M

更新日期：2002-11-15 00:00:00

abstract：:It has been repeatedly demonstrated that schizophrenic patients are impaired in the comprehension of sentences with complex syntax. We investigated the hypothesis that this syntactic comprehension impairment in schizophrenia is not a purely linguistic dysfunction, but rather the reflection of a cognitive sequence proc...

journal_title：Neuroreport

authors： Lelekov T,Franck N,Dominey PF,Georgieff N

更新日期：2000-07-14 00:00:00

abstract：:Nerve growth factor (NGF) promotes the survival of several neuronal populations, but recently it has also been shown to induce neuronal cell death. Here we report the effects of NGF on lesioned motoneurons. We have analyzed facial and sciatic motoneurons in newborn and adult BALB/c and C57BL/6 mice, in addition to mic...

journal_title：Neuroreport

authors： Terrado J,Monnier D,Perrelet D,Sagot Y,Mattenberger L,King B,Kato AC

更新日期：2000-05-15 00:00:00

abstract：:Hair cells in the frog semicircular canal, studied by the whole-cell patch-clamp technique, display three distinct Ca2+ currents: two non-inactivating components (L type and R type, the latter termed R2 in the following) and a second R type current (termed R1), which runs down first and inactivates in a Ca2+-dependent...

journal_title：Neuroreport

authors： Rispoli G,Martini M,Rossi ML,Rubbini G,Fesce R

更新日期：2000-08-21 00:00:00