Differential expression of transcription factors in the accumbens of an animal model of ADHD.

Abstract:

:Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-fos, c-fos, zif/268 in the shell, and the c-fos and zif/268 in the core, with an increased level of Jun-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Papa M,Sergeant JA,Sadile AG

doi

10.1097/00001756-199705060-00011

subject

Has Abstract

pub_date

1997-05-06 00:00:00

pages

1607-12

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

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