Abstract:
:Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-fos, c-fos, zif/268 in the shell, and the c-fos and zif/268 in the core, with an increased level of Jun-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Papa M,Sergeant JA,Sadile AGdoi
10.1097/00001756-199705060-00011subject
Has Abstractpub_date
1997-05-06 00:00:00pages
1607-12issue
7eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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