Abstract:
:The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gravielle MC,de Plazas SFdoi
10.1097/00001756-199510010-00015subject
Has Abstractpub_date
1995-10-23 00:00:00pages
2013-6issue
15eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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