Abstract:
:The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP-22) gene which results in abnormal myelination of the peripheral nervous system. However, the clinical symptoms observed in the mutant suggest abnormalities in the central nervous system. Using the Northern blot technique, we investigated the steady-state levels of mRNA encoding myelin protein genes in 8-day-old normal and trembler brains. We measured a two- to four-fold increase for myelin basic protein (MBP) and proteolipid protein (PLP) mRNAS in the trembler samples. Whether a relationship exists between this observation and the onset of the clinical symptoms is still to be determined.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bascles L,Bonnet J,Garbay Bdoi
10.1097/00001756-199406020-00015subject
Has Abstractpub_date
1994-06-02 00:00:00pages
1221-3issue
10eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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