Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution.

Abstract:

:A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the presence of two annexin VII isoforms (47 and 51 kDa) in human brain tissue as well as its exclusive expression in astroglial cells. An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations. Our findings indicate a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Clemen CS,Herr C,Lie AA,Noegel AA,Schröder R

doi

10.1097/00001756-200105080-00018

subject

Has Abstract

pub_date

2001-05-08 00:00:00

pages

1139-44

issue

6

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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