Abstract:
:A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the presence of two annexin VII isoforms (47 and 51 kDa) in human brain tissue as well as its exclusive expression in astroglial cells. An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations. Our findings indicate a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Clemen CS,Herr C,Lie AA,Noegel AA,Schröder Rdoi
10.1097/00001756-200105080-00018subject
Has Abstractpub_date
2001-05-08 00:00:00pages
1139-44issue
6eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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