Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution.


:A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the presence of two annexin VII isoforms (47 and 51 kDa) in human brain tissue as well as its exclusive expression in astroglial cells. An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations. Our findings indicate a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells.






Clemen CS,Herr C,Lie AA,Noegel AA,Schröder R




Has Abstract


2001-05-08 00:00:00












  • Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers.

    abstract::Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...


    pub_type: 杂志文章


    authors: Smith MA,Zhang LX,Lyons WE,Mamounas LA

    更新日期:1997-05-27 00:00:00

  • ACTH in the pigeon vestibular ganglion.

    abstract::Adrenocorticotropic hormone (ACTH) is a member of the opiocortin family of peptides. Within the central nervous system, ACTH-synthesizing neurons are generally considered to be located within the hypothalamus and are known to be involved in the neural circuitry underlying the integration of stress responses. We now re...


    pub_type: 杂志文章


    authors: Güntürkün O,Deviche P

    更新日期:1992-02-01 00:00:00

  • Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and...


    pub_type: 杂志文章,评审


    authors: Weydt P,Möller T

    更新日期:2005-04-25 00:00:00

  • Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation.

    abstract::The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation, nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p5...


    pub_type: 杂志文章


    authors: Zhou J,Fu Y,Tang XC

    更新日期:2001-07-20 00:00:00

  • The role of calcium in M-current inhibition by muscarinic agonists in rat sympathetic neurons.

    abstract::I have investigated the role of Ca2+ on M-current (IK(M)) inhibition by the muscarinic agonist oxo-M using the perforated patch voltage clamp technique. Oxo-M inhibited IK(M) in cultured SCG cells with an IC50 of 1.2 microM in 2 mM [Ca2+]o, and 13.1 microM in nominally Ca(2+)-free external solution. BAPTA-AM, ryanodin...


    pub_type: 杂志文章


    authors: Lamas JA

    更新日期:1999-08-02 00:00:00

  • Human thalamus: neurochemical mapping of inferior pulvinar complex.

    abstract::The primate pulvinar connects with the entire array of known visual areas and is postulated to play a role in selective visual attention. Recently, five separate neurochemical subdivisions of a region termed the inferior pulvinar (PI) complex were identified in monkeys. In the present study, similar histochemical proc...


    pub_type: 杂志文章


    authors: Cola MG,Gray DN,Seltzer B,Cusick CG

    更新日期:1999-12-16 00:00:00

  • Apoptosis in metabolic myopathies.

    abstract::DNA fragmentation, the hallmark of apoptosis, has been recently investigated with contradictory results in several skeletal muscle disorders. Using in situ labeling of nuclear DNA fragmentation, we have tested the possibility that apoptosis might occur in muscles from patients with mitochondrial respiratory chain defe...


    pub_type: 杂志文章


    authors: Monici MC,Toscano A,Girlanda P,Aguennouz M,Musumeci O,Vita G

    更新日期:1998-07-13 00:00:00

  • Spontaneous saccades under different visual conditions in the pigeon.

    abstract::Spontaneous saccades of both eyes were recorded in head-restrained pigeons placed in 6 different visual conditions (darkness and biocular, uniocular, frontal or lateral viewing). Most saccades (95%) were biocular and directed forward (around the beak axis) and backward (around the horizontal line). In the dark, the pr...


    pub_type: 杂志文章


    authors: Lemeignan M,Sansonetti A,Gioanni H

    更新日期:1992-01-01 00:00:00

  • Head and trunk orientation modulate visual neglect.

    abstract::Five patients with left visual neglect after right hemisphere lesions were examined with a line bisection and a reading task under five different conditions: head and trunk straight ahead, head or trunk oriented 20 degrees to the left and head or trunk oriented 20 degrees to the right. Fixation was always straight ahe...


    pub_type: 杂志文章


    authors: Schindler I,Kerkhoff G

    更新日期:1997-08-18 00:00:00

  • Mouse model for morningness/eveningness.

    abstract::Human morning/evening preferences has recently been reported to be associated with polymorphism of the 3' flanking region of the Clock gene, which was the first identified mammalian circadian clock gene. We recorded body temperature, spontaneous activity, electroencephalogram and electromyogram for 48 h in mice with J...


    pub_type: 杂志文章


    authors: Sei H,Oishi K,Morita Y,Ishida N

    更新日期:2001-05-25 00:00:00

  • Reading skill and structural brain development.

    abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...


    pub_type: 杂志文章


    authors: Houston SM,Lebel C,Katzir T,Manis FR,Kan E,Rodriguez GG,Sowell ER

    更新日期:2014-03-26 00:00:00

  • Neural discharge coupled to saccade offset in the cat visual cortex.

    abstract::The increase in neural activity in cat visual cortex associated with eye movements has been thought to reflect a replica of the motor command signal. We examined the timing of the saccade-related increase in neural activity in cat areas 17 and 18 in relation to saccade onset and offset. The increase in activity was te...


    pub_type: 杂志文章


    authors: Park J,Lee C

    更新日期:2000-06-05 00:00:00

  • Neural processing of illusory and real contours revealed by high-density ERP mapping.

    abstract::Event-related potential (ERP) studies have shown that responses to illusory (IC), as compared to no contours (NC), may differ within 200 ms following stimulus presentation. However, whether these responses reflect the modulation of similar, or the activation of distinct brain regions has never been assessed. Using ERP...


    pub_type: 杂志文章


    authors: Pegna AJ,Khateb A,Murray MM,Landis T,Michel CM

    更新日期:2002-05-24 00:00:00

  • Time course and specificity of event-related potentials to emotional expressions.

    abstract::To clarify the time course of neural responses to faces with different emotional expressions, we used event-related potential (ERP) and reaction time measures. Faces expressing four different emotions (happy, neutral, fearful, disgusted) and houses were shown in both upright and inverted orientations while subjects pe...


    pub_type: 杂志文章


    authors: Ashley V,Vuilleumier P,Swick D

    更新日期:2004-01-19 00:00:00

  • Working memory failure by stimulation of hippocampal adenosine A1 receptors in rats.

    abstract::THE highly selective adenosine A1 receptor agonist N6-cyclohexyladenosine (CHA) significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in the working memory task with a three-panel runway setup, when injected bilaterally at 0.3 and 1....


    pub_type: 杂志文章


    authors: Ohno M,Watanabe S

    更新日期:1996-11-25 00:00:00

  • Serum immunoglobulins in brain tumours and lumbar disc diseases.

    abstract::Changes of serum immunoglobulin (Ig) concentrations may occur in both brain tumours and lumbar disc diseases (LDD). The purpose of this study was to investigate the changes of pre- and post-operative serum Ig levels in brain tumours and LDDs. Serum IgG, IgA and IgM levels were measured in 127 patients with brain tumou...


    pub_type: 临床试验,杂志文章


    authors: Yüceer N,Arasil E,Temiz C

    更新日期:2000-02-07 00:00:00

  • Vestibular memory-contingent saccades involve somatosensory input from the body support.

    abstract::Humans use vestibular head-in-space information when redirecting gaze towards remembered target location in space. This study shows that neck input is also involved. Normal subjects performed saccades towards remembered locations in space of a previously seen target following passive horizontal rotations of the head o...


    pub_type: 杂志文章


    authors: Mergner T,Nasios G,Anastasopoulos D

    更新日期:1998-05-11 00:00:00

  • Evidence that matrix recognition contributes to stabilization but not induction of LTP.

    abstract::Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, th...


    pub_type: 杂志文章


    authors: Xiao P,Bahr BA,Staubli U,Vanderklish PW,Lynch G

    更新日期:1991-08-01 00:00:00

  • Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.

    abstract::DNA methylation is important for controlling gene expression and is catalyzed by DNA methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that mice expressing reduced levels of Dnmt1 are protected from cerebral ischemia. Here, we used the cre/loxP system to produce conditional mutants that l...


    pub_type: 杂志文章


    authors: Endres M,Fan G,Meisel A,Dirnagl U,Jaenisch R

    更新日期:2001-12-04 00:00:00

  • Neuregulin is associated with nerve regeneration in axonal neuropathies.

    abstract::Neuregulins (NRG), the only trophic factors known to support Schwann cell survival, have a potential for use in treatment of patients with chronic neuropathies. Expression of one NRG isoform, NRG-beta1, was increased in axons in the early phase of axonal degeneration in nerve biopsy specimens from patients with neurop...


    pub_type: 杂志文章


    authors: Oka N,Kawasaki T,Matsui M,Tachibana H,Sugita M,Akiguchi I

    更新日期:2000-11-27 00:00:00

  • Long-term potentiation in the perirhinal-hippocampal pathway is NMDA dependent.

    abstract::The putative memory mechanism known as long-term potentiation (LTP) has been described in both NMDA-dependent and non-NMDA-dependent forms. The aim of the present study was to determine which of these forms described the LTP generated between perirhinal cortex (PRC) and hippocampus, two structures which have previousl...


    pub_type: 杂志文章


    authors: Liu P,Bilkey DK

    更新日期:1996-05-17 00:00:00

  • Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats.

    abstract::We investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats. Nicotine (0.3 mg kg-1, s.c.) or DCS (10 mg kg-1, i.p.) enhanced acquisition of th...


    pub_type: 杂志文章


    authors: Riekkinen M,Riekkinen P Jr

    更新日期:1997-02-10 00:00:00

  • Dominance for language and spatial processing: limited capacity of a single hemisphere.

    abstract::Using functional magnetic resonance imaging during word generation and spatial judgement (Landmark task), we investigated how hemispheric specializations for language and spatial processing interact in healthy individuals. We found individuals with atypical, right-hemispheric dominance for language to have more bilate...


    pub_type: 杂志文章


    authors: Jansen A,Flöel A,Menke R,Kanowski M,Knecht S

    更新日期:2005-06-21 00:00:00

  • Attracting attention to the illusory location of a sound: reflexive crossmodal orienting and ventriloquism.

    abstract::Sound localization can be affected by vision; in the ventriloquism effect, sounds that are hard to localize within hearing become mislocalized toward the location of concurrent visual events. Here we tested whether spatial attention is drawn to the illusory location of a ventriloquized sound. The study exploited our p...


    pub_type: 杂志文章


    authors: Spence C,Driver J

    更新日期:2000-06-26 00:00:00

  • LTP in the barrel cortex of adult rats.

    abstract::Intrinsic circuitry in the barrel cortex has been shown to be readily modifiable in response to changes in the patterns of sensory input, even in adult animals. It is believed that sensory experience modifies synaptic circuits by imposing specific patterns of repetitive presynaptic and postsynaptic coactivity, i.e. by...


    pub_type: 杂志文章


    authors: Aroniadou-Anderjaska V,Keller A

    更新日期:1995-11-27 00:00:00

  • Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses.

    abstract::Intracerebral or intraspinal grafting of genetically modified primary fibroblasts has been shown to enhance functional recovery in several models of CNS disease, including spinal cord injury. Most of these studies utilized retrovirus vectors. In this report, we describe in vitro conditions for genetically modifying pr...


    pub_type: 杂志文章


    authors: Liu Y,Himes BT,Tryon B,Moul J,Chow SY,Jin H,Murray M,Tessler A,Fischer I

    更新日期:1998-04-20 00:00:00

  • NMDA-stimulated expression of BDNF mRNA in cultured cerebellar granule neurones.

    abstract::The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...


    pub_type: 杂志文章


    authors: Favaron M,Manev RM,Rimland JM,Candeo P,Beccaro M,Manev H

    更新日期:1993-09-03 00:00:00

  • Neurofilament-negative neurones exhibit HVA Ca2+ currents with faster inactivation kinetics.

    abstract::The whole cell configuration of the patch clamp technique was used to study the biophysical and pharmacological properties of voltage activated Ca2+ channel currents on hippocampal neurones cultured in the presence or absence of foetal calf serum. In the presence of serum cells were intensively immunostained with neur...


    pub_type: 杂志文章


    authors: Bertollini L,Cattaneo A,Cherubini E

    更新日期:1995-04-19 00:00:00

  • Mesencephalic astrocyte-derived neurotrophic factor enhances nigral gamma-aminobutyric acid release.

    abstract::Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) recepto...


    pub_type: 杂志文章


    authors: Zhou C,Xiao C,Commissiong JW,Krnjević K,Ye JH

    更新日期:2006-02-27 00:00:00

  • NMR intensity of corpus callosum differs with age but not with diagnosis of autism.

    abstract::NMR signal intensities in five regions of the midsagittal corpus callosum were measured in autism patients and normal controls. An age-related increase in signal was observed in the anterior regions in both groups. No significant differences in intensity were detected between the groups. The finding of normal myelinat...


    pub_type: 杂志文章


    authors: Belmonte M,Egaas B,Townsend J,Courchesne E

    更新日期:1995-06-19 00:00:00