Differential regulation of paired-pulse plasticity following LTP in the dentate gyrus.


:The mechanisms underlying the expression of long-term synaptic potentiation (LTP) in the lateral and medial perforant path inputs to the dentate gyrus were examined in pentobarbital anaesthetized rats. Lateral path LTP was accompanied by a robust, long-lasting reduction in lateral path paired-pulse facilitation (PPF). The reduction in PPF lasted for at least 1 h, and remained even after post-tetanic EPSP slopes were reduced to pre-tetanus levels. The induction of lateral path LTP and the corresponding reduction in PPF were blocked by the competitive NMDA receptor antagonist CPP. Medial path paired-pulse depression was not affected by medial path LTP. These data suggest that changes in transmitter release may contribute more to lateral path than to medial path LTP.






Christie BR,Abraham WC




Has Abstract


1994-01-12 00:00:00












  • GABAB-RI receptors in serotonergic neurons: effects of baclofen on 5-HT output in rat brain.

    abstract::The activation of GABAB receptors hyperpolarizes 5-HT neurons and reduces cell firing. In situ hybridization showed the presence of the GABAB-RI receptor transcript in virtually all 5-HT neurons of the dorsal and median raphe nuclei (DR and MnR, respectively) whereas the GAD transcript was present mainly outside these...


    pub_type: 杂志文章


    authors: Abellán MT,Adell A,Honrubia MA,Mengod G,Artigas F

    更新日期:2000-04-07 00:00:00

  • Pattern of distribution and co-localization of NOS and ATP in the myenteric plexus of human fetal stomach and intestine.

    abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...


    pub_type: 杂志文章


    authors: Belai A,Burnstock G

    更新日期:2000-01-17 00:00:00

  • Neural correlates of the modified Stroop effect in post-traumatic stress disorder: an event-related potential study.

    abstract::Previous studies have provided electrophysiological evidence for attentional abnormalities in patients with post-traumatic stress disorder (PTSD). The present study examined the electrophysiological activity of trauma-exposed patients with or without a PTSD during a modified Stroop task. The PTSD group showed a reduce...


    pub_type: 杂志文章


    authors: Chen X,Wei D,Dupuis-Roy N,Du X,Qiu J,Zhang Q

    更新日期:2012-12-19 00:00:00

  • Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease.

    abstract::Recent studies have demonstrated a loss of cannabinoid CB1 receptors in the basal ganglia in Huntington's disease (HD), but there are no data on endocannabinoid levels in this disease. In the present study, we have addressed this question by using rats with bilateral intrastriatal injections of 3-nitropropionic acid (...


    pub_type: 杂志文章


    authors: Lastres-Becker I,Fezza F,Cebeira M,Bisogno T,Ramos JA,Milone A,Fernández-Ruiz J,Di Marzo V

    更新日期:2001-07-20 00:00:00

  • Role of exosomes induced by remote ischemic preconditioning in neuroprotection against cerebral ischemia.

    abstract::Remote ischemic preconditioning (RIPC) is an effective regimen for neuroprotection in ischemic stroke. Exosomes are extracellular vesicles released into the blood, where they can transfer signals throughout the body. Several studies have demonstrated that RIPC leads to many changes in circulating exosomes. However, th...


    pub_type: 杂志文章


    authors: Li Y,Ren C,Li H,Jiang F,Wang L,Xia C,Ji X

    更新日期:2019-08-14 00:00:00

  • BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons.

    abstract::In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...


    pub_type: 杂志文章


    authors: Frechilla D,García-Osta A,Palacios S,Cenarruzabeitia E,Del Rio J

    更新日期:2001-04-17 00:00:00

  • Localization of the somatostatin sst2(a) receptor in human cerebral cortex, hippocampus and cerebellum.

    abstract::The distribution and cellular localization of the somatostatin sst2(a) receptor was investigated in selected human brain areas using an anti-peptide antibody raised against a carboxy-terminal portion of the receptor protein. The sst2(a) receptor was found to be present on neurones and processes in the deep layers of t...


    pub_type: 杂志文章


    authors: Schindler M,Holloway S,Humphrey PP,Waldvogel H,Faull RL,Berger W,Emson PC

    更新日期:1998-02-16 00:00:00

  • POU-domain factor expression in the trigeminal ganglion and implications for herpes virus regulation.

    abstract::The restriction of herpes virus latency to mammalian sensory ganglia has led to a search for tissue-specific regulatory molecules in these neurons which alter viral gene expression. Based primarily on work in sensory-related cell lines, several prior reports have suggested that the POU-domain transcription factor Oct-...


    pub_type: 杂志文章


    authors: Turner EE,Fedtsova N,Rosenfeld MG

    更新日期:1996-11-25 00:00:00

  • The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm.

    abstract::An important issue regarding the neural basis of major depression is whether the functional brain changes associated with the affect disturbance seen in this syndrome are similar to those that accompany transient sadness in normal subjects. To address this question, we carried out an fMRI study using an emotional acti...


    pub_type: 杂志文章


    authors: Beauregard M,Leroux JM,Bergman S,Arzoumanian Y,Beaudoin G,Bourgouin P,Stip E

    更新日期:1998-10-05 00:00:00

  • Role of nitric oxide in 2-deoxy-D-glucose-induced hypothermia in rats.

    abstract::The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or N(G)-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibi...


    pub_type: 杂志文章


    authors: Carnio EC,Almeida MC,Fabris G,Branco LG

    更新日期:1999-09-29 00:00:00

  • Differential human brain activity induced by two perceptually indistinguishable gentle cutaneous stimuli.

    abstract::We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...


    pub_type: 杂志文章


    authors: Watanabe N,Ishii K,Hotta H,Oda K,Sakata M,Toyohara J,Ishiwata K

    更新日期:2013-05-29 00:00:00

  • Induction of NG108-15 cells differentiation by human bone marrow stromal cells.

    abstract::The survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells...


    pub_type: 杂志文章


    authors: Ho SH,So LH,Lai KO,Ip NY,Leung MF

    更新日期:1998-05-11 00:00:00

  • Photochemical stroke and brain-derived neurotrophic factor (BDNF) mRNA expression.

    abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...


    pub_type: 杂志文章


    authors: Comelli MC,Seren MS,Guidolin D,Manev RM,Favaron M,Rimland JM,Canella R,Negro A,Manev H

    更新日期:1992-06-01 00:00:00

  • Nuclear triiodothyronine receptor expression is regulated by axon-Schwann cell contact.

    abstract::Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. ...


    pub_type: 杂志文章


    authors: Walter IB

    更新日期:1993-11-18 00:00:00

  • Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.

    abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...


    pub_type: 杂志文章


    authors: Yamada S,Nomura T,Takano K,Fujita S,Miyake M,Miyake J

    更新日期:2008-11-19 00:00:00

  • Extended brain disinhibition following small photothrombotic lesions in rat frontal cortex.

    abstract::The effect of an ischaemic focal cortical lesion on the excitability of surrounding and remote brain areas was investigated. Infarcts were produced photothrombotically in rat frontal cortex and brain excitability was assessed by a extracellular paired-pulse stimulation in coronal slices 7 days later. The cortical lesi...


    pub_type: 杂志文章


    authors: Buchkremer-Ratzmann I,Witte OW

    更新日期:1997-01-20 00:00:00

  • Equivalent disruption of regional white matter microstructure in ageing healthy men and women.

    abstract::Diffusion tensor imaging was used to measure regional differences in brain white matter microstructure (intravoxel coherence) and macrostructure (intervoxel coherence) and age-related differences between men and women. Neuropsychiatrically healthy men and women, spanning the adult age range, showed the same pattern of...


    pub_type: 杂志文章


    authors: Sullivan EV,Adalsteinsson E,Hedehus M,Ju C,Moseley M,Lim KO,Pfefferbaum A

    更新日期:2001-01-22 00:00:00

  • Open field behaviour in rats: role of metabotropic glutamate receptors.

    abstract::Previous studies have shown that spatial memory retention is affected by the metabotropic glutamate receptor (mGluR) influencing agents (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and trans-azetidine-2,4-dicarboxylic acid (tADA). In the present investigation we examined whether the mGluR antagonist MCPG (20 mM an...


    pub_type: 杂志文章


    authors: Wetzel W,Wagner T,Reymann KG,Riedel G

    更新日期:1995-11-27 00:00:00

  • Transient expression of the NR2C subunit of the NMDA receptor in developing rat brain.

    abstract::Pharmacologically distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, ...


    pub_type: 杂志文章


    authors: Pollard H,Khrestchatisky M,Moreau J,Ben Ari Y

    更新日期:1993-04-01 00:00:00

  • Neurotransmission in the brain by diffusion through the extracellular fluid: a review.

    abstract::Synaptic or 'hard wired' neurotransmission in the brain, subject to modulation by a class of substances called modulators, has been the dominant model of brain function. However, increasing evidence for alternate non-synaptic neurotransmission mechanisms is forcing consideration of a more inclusive model. Evidence is ...


    pub_type: 杂志文章,评审


    authors: Bach-y-Rita P

    更新日期:1993-04-01 00:00:00

  • Neurofilament-negative neurones exhibit HVA Ca2+ currents with faster inactivation kinetics.

    abstract::The whole cell configuration of the patch clamp technique was used to study the biophysical and pharmacological properties of voltage activated Ca2+ channel currents on hippocampal neurones cultured in the presence or absence of foetal calf serum. In the presence of serum cells were intensively immunostained with neur...


    pub_type: 杂志文章


    authors: Bertollini L,Cattaneo A,Cherubini E

    更新日期:1995-04-19 00:00:00

  • Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors.

    abstract::A number of epidemiological studies suggest that estrogen therapy is linked to a reduced risk of developing Alzheimer's disease (AD). The present study was conducted to evaluate the effect of 17beta-estradiol on beta-amyloid (Abeta)-induced toxicity and was performed in rat pheochromocytoma PC 12 cells by measuring th...


    pub_type: 杂志文章


    authors: Svensson AL,Nordberg A

    更新日期:1999-11-26 00:00:00

  • Histamine slows the onset of desensitization of rat cortical NMDA receptors.

    abstract::The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10...


    pub_type: 杂志文章


    authors: Zwart R,Blank T,Spiess J

    更新日期:1996-09-02 00:00:00

  • α1-Adrenoceptors in the hippocampal dentate gyrus involved in learning-dependent long-term potentiation during active-avoidance learning in rats.

    abstract::The hippocampus is the key structure for learning and memory in mammals and long-term potentiation (LTP) is an important cellular mechanism responsible for learning and memory. The influences of norepinephrine (NE) on the modulation of learning and memory, as well as LTP, through β-adrenoceptors are well documented, w...


    pub_type: 杂志文章


    authors: Lv J,Zhan SY,Li GX,Wang D,Li YS,Jin QH

    更新日期:2016-11-09 00:00:00

  • Vestibular memory-contingent saccades involve somatosensory input from the body support.

    abstract::Humans use vestibular head-in-space information when redirecting gaze towards remembered target location in space. This study shows that neck input is also involved. Normal subjects performed saccades towards remembered locations in space of a previously seen target following passive horizontal rotations of the head o...


    pub_type: 杂志文章


    authors: Mergner T,Nasios G,Anastasopoulos D

    更新日期:1998-05-11 00:00:00

  • Biochemical markers of cognition: a proton MR spectroscopy study of normal human brain.

    abstract::In the current study we explored the relationship between neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) and cognitive ability assessed with a battery of neuropsychological tests. Forty-five participants were recruited from the local college community, and examined utilizing neuropsycholo...


    pub_type: 临床试验,杂志文章


    authors: Jung RE,Yeo RA,Chiulli SJ,Sibbitt WL Jr,Weers DC,Hart BL,Brooks WM

    更新日期:1999-11-08 00:00:00

  • Modelling transfer characteristics of vestibular neurons in the fastigial nucleus of the behaving monkey on the basis of canal-otolith interaction.

    abstract::The interaction of vestibular inputs with different dynamic and spatial behavior, i.e., canal-otolith interaction, leads to spatio-temporal convergence. Vestibular neurons in the fastigial nucleus often exhibit spatio-temporal convergence. The present report demonstrates that the discharge rates of most vestibular neu...


    pub_type: 杂志文章


    authors: Wilden A,Glasauer S,Kleine JF,Büttner U

    更新日期:2002-05-07 00:00:00

  • A suprachiasmatic nucleus projecting retinal ganglion cell exhibits an unusually large dendritic field in the hamster.

    abstract::The majority of retinal ganglion cells innervating the suprachiasmatic nucleus are intrinsically light sensitive, while the rest are conventional ganglion cells that collect inputs through conventional photoreceptors. Here we report a rarely encountered ganglion cell that had a dendritic field covering approximately 1...


    pub_type: 杂志文章


    authors: Pu M,Chen B,Li RS,Tay D,So KF

    更新日期:2006-10-02 00:00:00

  • GDNF and neublastin protect against NMDA-induced excitotoxicity in hippocampal slice cultures.

    abstract::The potential neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) and neublastin (NBN) against NMDA-induced excitotoxicity were examined in hippocampal brain slice cultures. Recombinant human GDNF (25-100 ng/ ml) or NBN, in medium conditioned by growth of transfected, NBN-producing HiB5 cells...


    pub_type: 杂志文章


    authors: Bonde C,Kristensen BW,Blaabjerg M,Johansen TE,Zimmer J,Meyer M

    更新日期:2000-12-18 00:00:00

  • High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4+/-11.0...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rollnik JD,Huber TJ,Mogk H,Siggelkow S,Kropp S,Dengler R,Emrich HM,Schneider U

    更新日期:2000-12-18 00:00:00