Differential regulation of paired-pulse plasticity following LTP in the dentate gyrus.

Abstract:

:The mechanisms underlying the expression of long-term synaptic potentiation (LTP) in the lateral and medial perforant path inputs to the dentate gyrus were examined in pentobarbital anaesthetized rats. Lateral path LTP was accompanied by a robust, long-lasting reduction in lateral path paired-pulse facilitation (PPF). The reduction in PPF lasted for at least 1 h, and remained even after post-tetanic EPSP slopes were reduced to pre-tetanus levels. The induction of lateral path LTP and the corresponding reduction in PPF were blocked by the competitive NMDA receptor antagonist CPP. Medial path paired-pulse depression was not affected by medial path LTP. These data suggest that changes in transmitter release may contribute more to lateral path than to medial path LTP.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Christie BR,Abraham WC

doi

10.1097/00001756-199401120-00003

subject

Has Abstract

pub_date

1994-01-12 00:00:00

pages

385-8

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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