Abstract:
:DCC is a member of the immunoglobulin superfamily of cell adhesion molecules, whose role in the function of the adult nervous system is unknown. DCC mRNA expression was studied in adult rat dorsal hippocampal sections using in situ hybridization histochemistry. High levels of DCC transcript were detected in hippocampus and medial habenula, whereas lower mRNA expression was found in cerebral cortex, hypothalamus and thalamus. The higher relative expression of DCC mRNA in hippocampus, compared with the remainder of the brain was confirmed using RT-PCR analysis. These data confirm the presence of DCC mRNA in adult rat brain and indicate that DCC mRNA is differentially expressed between forebrain regions, suggesting a role for DCC in the function of the adult rat central nervous system.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Volenec A,Bhogal RK,Moorman JM,Leslie RA,Flanigan TPdoi
10.1097/00001756-199709080-00022subject
Has Abstractpub_date
1997-09-08 00:00:00pages
2913-7issue
13eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells v...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200303030-00009
更新日期:2003-03-03 00:00:00
abstract::The aim of this study was to identify differences in structural and functional brain connectivity between poststroke mild and severe motor impairment. Twenty-four chronic stroke patients who underwent resting-state functional MRI and diffusion tensor image were retrospectively included. All patients were classified in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001247
更新日期:2019-05-01 00:00:00
abstract::The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection of complete Freund's adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistoche...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403220-00016
更新日期:2004-03-22 00:00:00
abstract::Since the characterization of orphanin FQ (OFQ), the endogenous ligand of ORL1 receptor, much work has focused on its physiological functions. OFQ was reported to antagonize the effect of opioid-induced antinociception, although its mechanism remains obscure. In the present study, whole-cell patch clamp recording tech...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00034
更新日期:1998-06-22 00:00:00
abstract::Propofol is widely used for induction and maintenance of anaesthesia, which causes a rapid loss of consciousness. So far the mechanisms underlying the effect of propofol are still largely unknown. Here, we found that microinjection of propofol in the lateral hypothalamus caused a significant decrease in wakefulness an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001292
更新日期:2019-10-09 00:00:00
abstract::Extracellular pH transients were evoked in rat hippocampal brain slices by activation of a monosynaptic inhibitory pathway following pharmacological blockade of glutaminergic transmission. Repetitive stimulation in stratum radiatum near the recording site in stratum pyramidale evoked an immediate alkaline shift which ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199201000-00028
更新日期:1992-01-01 00:00:00
abstract::Neonatal peripheral inflammation has been shown to alter the neural circuitry of the spinal cord in adult rats. However, the temporal and spatial changes in the distribution of primary afferent terminals immediately following a neonatal inflammatory stimulus remains unclear. In the present study we found that intrapla...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310270-00007
更新日期:2003-10-27 00:00:00
abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00016
更新日期:2002-09-16 00:00:00
abstract::Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 el...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00010
更新日期:2001-09-17 00:00:00
abstract::There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatori...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834f1765
更新日期:2012-02-15 00:00:00
abstract::To test the possible role of ATP in transducing or modulating touch sensation, an isolated skin-nerve preparation from the toad, Bufo marinus, perfused on the inner side, was used to examine the effects of ATP on slowly adapting (SA) and rapidly adapting (RA) mechanoreceptors, identified by ramp and hold indentation o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200208070-00019
更新日期:2002-08-07 00:00:00
abstract::Functional brain imaging techniques hold many promises as the methods of choice for identifying areas involved in the execution of language functions. The success of any of these techniques in fulfilling this goal depends upon their ability to produce maps of activated areas that overlap with those obtained through st...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199901180-00026
更新日期:1999-01-18 00:00:00
abstract::Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283405bad
更新日期:2010-12-08 00:00:00
abstract::The distribution of PKCepsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCepsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00006
更新日期:2000-03-20 00:00:00
abstract::Resident microglial cells contribute to activation and expansion of T cells under inflammatory conditions within the CNS. However, there is no evidence how interactions between microglia and T cells affect CNS inflammation. We evaluated the effect of glial cell-derived dendritic cells (GC-DC) in expanding and eliminat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00012
更新日期:2002-01-21 00:00:00
abstract::The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives glutamatergic inputs from the prefrontal cortex and several subcortical regions. The glutamate...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000708
更新日期:2017-01-01 00:00:00
abstract::This study used event-related functional magnetic resonance imaging to investigate the neural basis underlying the sequential involvement of syntactic processing in the course of sentence comprehension. In experiments, a noun, case particle, and verb were presented one by one, constituting simple sentences in Japanese...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282e9a87c
更新日期:2007-09-17 00:00:00
abstract::Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00052
更新日期:2001-12-21 00:00:00
abstract::Exosomes derived from Schwann cells have been known to have a variety of functions in the development and repair of the peripheral nervous system, and cyclic AMP (cAMP) is a key inducer of Schwann cell differentiation. In the present study, we aimed to study the effect of exosomes derived from differentiated Schwann c...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001435
更新日期:2020-05-07 00:00:00
abstract::Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase posit...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00011
更新日期:1998-05-11 00:00:00
abstract::Low doses of estrogen (E) were given to ovariectomized (OVX) rats and the ventromedial hypothalamic nucleus (VMN) was examined at the ultrastructural level. Administration of 10 micrograms of E for two consecutive days resulted in an increase in the number of axodendritic synapses in the VMN in comparison to OVX rats ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199107000-00006
更新日期:1991-07-01 00:00:00
abstract::The study aimed to compare the whole-brain gray matter volume (GMV) and white matter volume (WMV) difference between primary angle closure glaucoma (PACG) patients and health controls (HCs) using a voxel-based morphometry method. A total of 27 patients with PACG (17 males and 10 females) and 27 HCs (17 males and 10 fe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001126
更新日期:2018-11-07 00:00:00
abstract::We have established an in-vitro coculture-system of adult rat retina with fetal midbrain explants to examine whether regenerating central nervous system axons are still able to recognize appropriate target neurons. Our results show that the retinal ganglion cell axons regenerate their axons and reinnervate the retino-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199110000-00007
更新日期:1991-10-01 00:00:00
abstract::The expression pattern of metabotropic glutamate receptor 1alpha (mGluR1alpha) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1alpha immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) wher...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000074344.81633.e4
更新日期:2003-05-23 00:00:00
abstract::Spatial neglect has been explained as an impairment in the representation of extrapersonal space. One account suggests that representations of extrapersonal space are spatially compressed following neglect. In support of this view it has been demonstrated that neglect patients systematically underestimate the size of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00035
更新日期:1997-12-01 00:00:00
abstract::To clarify possible interaction between the ventral hippocampal cannabinoid CB2 receptors and the cholinergic system in control of the memory process, the effects of cannabinoid and acetylcholine receptor agents on memory consolidation have been investigated in mice. Animals implanted with bilateral cannulas at the CA...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001381
更新日期:2020-01-27 00:00:00
abstract::The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues. However, the distribution of this channel in human sensory neurons is not known. Using a specific antibody, we have demonstrated intense P2X3 ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00019
更新日期:2000-04-07 00:00:00
abstract::Microinjection of neuropeptide Y (NPY) into the paraventricular nucleus (PVN) of the hypothalamus stimulates eating and increases respiratory quotient. In contrast, administration of opioid receptor antagonists reduces food intake and suppresses NPY-induced feeding. The present study examined whether naloxone methiodi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00016
更新日期:2000-03-20 00:00:00
abstract::The pathogenesis of cerebral ischemia/reperfusion (I/R) involves cytokine/chemokine production, inflammatory cell influx, astrogliosis, cytoskeletal protein degradation and breakdown of the blood-brain barrier. (-)-Naloxone is able to reduce infarct volume and has been used as a therapeutic agent for cerebral I/R inju...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105080-00038
更新日期:2001-05-08 00:00:00
abstract::Pyramidal cells were injected intracellularly in fixed, flat-mounted cortical slices taken from the first and fourth visual areas (V1 and V4, respectively) and cytoarchitectonic areas TEO and TE of two age and gender-matched vervet monkeys and the size, branching complexity and spine density of their basal dendritic t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200506210-00017
更新日期:2005-06-21 00:00:00