Abstract:
:In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are preferentially expressed in small (< 25 microm diameter) DRG neurons. There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively. A parallel reduction in expression is shown in axotomized < 25 microm diameter DRG neurons for IGF-I (47%) but not for IGF-IR. The loss of IGF-I support to a population of predominantly nociceptive neurons may contribute to neuropathic pain observed in these models.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Craner MJ,Klein JP,Black JA,Waxman SGdoi
10.1097/00001756-200209160-00016subject
Has Abstractpub_date
2002-09-16 00:00:00pages
1649-52issue
13eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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