Increased severity of experimental colitis in alpha 5 nicotinic acetylcholine receptor subunit-deficient mice.

abstract：:We investigated the role of melatonin in the induction of gastric lesions induced by water immersion restraint stress or centrally administered thyrotropin-releasing hormone (TRH). Melatonin (0.1-1 ng) injected intracisternally (i.c) 30 min prior to stress dose-dependently inhibited the induction of gastric lesions by...

journal_title：Neuroreport

authors： Kato K,Murai I,Asai S,Komuro S,Matsuno Y,Matsukawa Y,Kurosaka H,Iwasaki A,Ishikawa K,Arakawa Y

更新日期：1997-07-07 00:00:00

abstract：:We previously reported that clusterin enhances astrocyte proliferation and extracellular signal-regulated kinase (ERK) activity. It, however, remains largely unknown how clusterin promotes cell growth. Here, we investigate the signaling pathway and related molecules underlying astrocyte proliferation by clusterin. Exo...

journal_title：Neuroreport

authors： Shim YJ,Shin YJ,Jeong SY,Kang SW,Kim BM,Park IS,Min BH

更新日期：2009-03-04 00:00:00

abstract：:Antisera were produced against synthetic peptides predicted from the recent cloning of a delta opioid receptor, DOR-1. Confocal microscopic examination of immunostained spinal cord sections revealed that DOR-1 immunoreactive (-ir) nerve fibers and terminals form a moderately dense plexus within the superficial dorsal ...

journal_title：Neuroreport

authors： Dado RJ,Law PY,Loh HH,Elde R

更新日期：1993-12-13 00:00:00

abstract：:Melatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of melatonin on spinal cord nociceptive transmission was studied in rats by assessing wid-up activity in a C-fiber reflex responses paradigm evoked by repetitiv...

journal_title：Neuroreport

authors： Laurido C,Pelissie T,Soto-Moyano R,Valladares L,Flores F,Hernández A

更新日期：2002-01-21 00:00:00

abstract：:Although prenatal stress has been repeatedly shown to inhibit adult neurogenesis in the dentate gyrus of offspring, its effects on embryonic and early postnatal brain development are not well described. Here, using the cell proliferation marker 5-bromo-2'-deoxyuridine, we examine for the first time the effect of prena...

journal_title：Neuroreport

authors： Kawamura T,Chen J,Takahashi T,Ichitani Y,Nakahara D

更新日期：2006-10-02 00:00:00

abstract：:Counter-stimulation reduces pain perception; however, the role of attention during this process is rarely discussed despite attention itself being a well known modulator of pain perception. This study investigated the effect of attentional modulation on pain perception during counter-stimulation using fMRI. Subjects r...

journal_title：Neuroreport

authors： Longe SE,Wise R,Bantick S,Lloyd D,Johansen-Berg H,McGlone F,Tracey I

更新日期：2001-07-03 00:00:00

abstract：:Interleukin-2 and its receptors are present in hippocampal structures, particularly the pyramidal cell layer. In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique. RhIL-2 depressed ...

journal_title：Neuroreport

authors： Plata-Salamán CR,ffrench-Mullen JM

更新日期：1993-05-01 00:00:00

abstract：:The aim of the present study was to examine the effects of nicotinamide, a co-factor in the electron transport chain, on the relationship between methamphetamine (MA)-induced striatal dopamine (DA) depletion and energy metabolism change. Four injections of MA (10 mg/kg, i.p.) at 2 h intervals resulted in decreases of ...

journal_title：Neuroreport

authors： Huang NK,Wan FJ,Tseng CJ,Tung CS

更新日期：1997-05-27 00:00:00

abstract：:Melatonin, a hormone from the pineal gland, was tested for its anticonvulsant effects in male gerbils. Daily administration of melatonin (25 micrograms injection-1, s.c.) for ten weeks reduced the number and severity of seizures (total convulsion score: 7.67 +/- 1.83 in controls vs 2.47 +/- 0.90 in melatonin-injected ...

journal_title：Neuroreport

authors： Champney TH,Champney JA

更新日期：1992-12-01 00:00:00

abstract：:24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease. In this study, we examined the effects of 2...

journal_title：Neuroreport

authors： Alexandrov P,Cui JG,Zhao Y,Lukiw WJ

更新日期：2005-06-21 00:00:00

abstract：:The death of spinal motoneurones after axotomy provides a useful model for studying novel factors which prevent motoneurone loss in vivo. Peripheral nerves of newborn rats were unilaterally transected and treated with either a vehicle solution or leukaemia inhibitory factor (LIF). Compared with the vehicle controls, t...

journal_title：Neuroreport

authors： Cheema SS,Richards LJ,Murphy M,Bartlett PF

更新日期：1994-04-14 00:00:00

abstract：:The aim of this study was to examine the effects of voluntary contraction (VC) on the modulation of reciprocal inhibition induced by patterned electrical stimulation (PES) in healthy individuals. Twelve healthy volunteers participated in this study. PES was applied to the common peroneal nerve with a train of 10 pulse...

journal_title：Neuroreport

authors： Takahashi Y,Fujiwara T,Yamaguchi T,Kawakami M,Mizuno K,Liu M

更新日期：2017-05-24 00:00:00

abstract：:The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inosi...

journal_title：Neuroreport

authors： Jung YH,Kim H,Jeon SY,Kwon JM,Kim YC,Lee WJ,Lee D,Lee JY,Moon JY,Kang DH

更新日期：2019-01-16 00:00:00

abstract：:Diabetes is often associated with impairments in brain functioning. However, the injury of specific functioning areas of the brain is not clear. To address this problem, the present study was designed to investigate possible brain functioning change in specific brain areas, particularly in areas associated with vision...

journal_title：Neuroreport

authors： Wang Z,Lu Z,Li J,Pan C,Jia Z,Chen H,Ge X

更新日期：2017-01-18 00:00:00

abstract：:A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...

journal_title：Neuroreport

authors： Seutin V,Massotte L,Renette MF,Dresse A

更新日期：2001-02-12 00:00:00

abstract：:Microglial activation is thought to contribute to the progression of selective motor neuron death during amyotrophic lateral sclerosis (ALS). As minocycline has been shown to inhibit microglial activation, the therapeutic efficacy of this tetracycline derivative in the G93A mice model for familial ALS was tested. This...

journal_title：Neuroreport

authors： Van Den Bosch L,Tilkin P,Lemmens G,Robberecht W

更新日期：2002-06-12 00:00:00

abstract：:Humans afflicted with mood disorders respond differently to antidepressant drug therapy. Different responses to psychoactive drugs are also observed in rats, and specific strains exhibit substantial differences in gene expression following synaptic activity. We examined the effects of fluoxetine on the induction of Fo...

journal_title：Neuroreport

authors： Horowitz JM,Hallas BH,Torres G

更新日期：2002-12-20 00:00:00

abstract：:The hypothalamus is a limbic structure involved in the emergence and persistence of major depressive disorder symptoms. Previous studies have indicated that major depressive disorder patients exhibited dysregulation between the hypothalamus and cerebral regions. However, it is still unclear about the exact hypothalami...

journal_title：Neuroreport

authors： Wang D,Xue SW,Tan Z,Wang Y,Lian Z,Sun Y

更新日期：2019-11-06 00:00:00

abstract：:Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis (ALS), yet it remains unclear why some groups of motoneurons (MNs) are more vulnerable to degeneration than others. Our aim was to compare, in normal adult rats, the expression of Group I metabotropic glutamate receptors (mGluR...

journal_title：Neuroreport

authors： Laslo P,Lipski J,Funk GD

更新日期：2001-07-03 00:00:00

abstract：:Amyloid beta-peptide (A beta) is a major component of neuritic plaques, a feature of Alzheimer's disease (AD) brains. Recently, we showed that A beta adopts two major conformational states in solution, which differ in their abilities to form amyloid. These are highly amyloidogenic conformer (A beta ac) with a high con...

journal_title：Neuroreport

authors： Soto C,Golabek A,Wisniewski T,Castaño EM

更新日期：1996-02-29 00:00:00

abstract：:We previously reported that the methanol extract of Ashwagandha (roots of Dunal) induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells. Double immunostaining ...

journal_title：Neuroreport

authors： Kuboyama T,Tohda C,Zhao J,Nakamura N,Hattori M,Komatsu K

更新日期：2002-10-07 00:00:00

abstract：:To test the effect of nitric oxide synthase (NOS) blockade on the ventilatory responses to carotid body chemoreceptor stimulation in freely behaving animals, chronically instrumented adult Sprague-Dawley rats received increasing intravenous doses of sodium cyanide (NaCN; 0-300 micrograms kg-1) before and after i.v. ad...

journal_title：Neuroreport

authors： Gozal D,Gozal E,Gozal YM,Torres JE

更新日期：1996-04-26 00:00:00

abstract：:This study aimed to examine the spontaneous hemodynamic fluctuations and the dysfunctional brain regions in patients with generalized anxiety disorder (GAD) using resting-state functional MRI. Previous studies have demonstrated some neural networks that are different in this patient group compared with healthy control...

journal_title：Neuroreport

authors： Li C,Su S,Wu H,Zhu Y

更新日期：2018-03-21 00:00:00

abstract：:The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...

journal_title：Neuroreport

authors： Mikuni N,Nishiyama K,Babb TL,Ying Z,Najm I,Okamoto T,Lüders HO,Wylie C

更新日期：1999-05-14 00:00:00

abstract：:Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 7...

journal_title：Neuroreport

authors： Kruglikov I,Shutov L,Potapenko E,Voitenko N,Kostyuk P

更新日期：2001-11-16 00:00:00

abstract：:The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell de...

journal_title：Neuroreport

authors： Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF

更新日期：2004-07-19 00:00:00

abstract：:Short-term exposure of primary cultures of cerebellar granule cells from neonatal rat brain to high concentrations of glutamate results in neuronal degeneration. We found that glutamate, before causing neuronal degeneration, induced a significant increase of Tau protein immunostaining. Time-course experiments revealed...

journal_title：Neuroreport

authors： Pizzi M,Valerio A,Ribola M,Spano PF,Memo M

更新日期：1993-06-01 00:00:00

abstract：:Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors o...

journal_title：Neuroreport

authors： Laprade N,Soghomonian JJ

更新日期：1995-10-02 00:00:00

abstract：:The aim of this study was to evaluate the contribution of ionotropic glutamate receptors to kindled seizure-evoked somatostatin release in the hippocampus, using a microdialysis approach. Basal and amygdala stimulation-evoked somatostatin-like immunoreactivity (-LI) release was significantly greater in kindled compare...

journal_title：Neuroreport

authors： Marti M,Bregola G,Binaschi A,Gemignani A,Simonato M

更新日期：2000-09-28 00:00:00

abstract：:Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confi...

journal_title：Neuroreport

authors： Burazin TC,Gundlach AL

更新日期：1995-10-02 00:00:00