Effect of melatonin on rat spinal cord nociceptive transmission.

Abstract:

:Melatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of melatonin on spinal cord nociceptive transmission was studied in rats by assessing wid-up activity in a C-fiber reflex responses paradigm evoked by repetitive (0.6 Hz) electric stimulation. Intraperitoneal administration of 1.25, 2.5, 5.0 and 10.0 mg/kg melatonin induced a dose-dependent inhibition of spinal wind-up activity, the higher dose of the drug used being able to depress completely the C reflex gain. Results indicate that melatonin markedly depresses spinal wind-up in rats, probably through hyperpolarization of dorsal horn neurons consecutive to melatonin binding to membrane receptors, and/or via intracellular interference with a NMDA receptor-dependent nitric oxide generating pathway.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Laurido C,Pelissie T,Soto-Moyano R,Valladares L,Flores F,Hernández A

doi

10.1097/00001756-200201210-00021

subject

Has Abstract

pub_date

2002-01-21 00:00:00

pages

89-91

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

13

pub_type

杂志文章
  • Changes occur in the ability to promote axonal regeneration as the post-injury period increases.

    abstract::This study tested whether adult rat brain stem neurons could respond to growth or trophic factors provided after an extended post-injury period. The number of neurons that regenerated their axon into a peripheral nerve graft following exposure to ciliary neurotrophic factor (CNTF) 8 weeks after a cervical lesion was c...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199702100-00034

    authors: Houle JD,Ye JH

    更新日期:1997-02-10 00:00:00

  • Noradrenergic inputs enhance the response of neurosecretory cells to osmotic stimulation.

    abstract::Extracellular recordings from neurosecretory cells in the hypothalamic paraventricular nucleus (PVN) displayed either an excitation or no response following electrical stimulation (5 Hz) of the A1 noradrenergic region of the ventrolateral medulla, and exhibited either an increase or no effect in neuronal activity in r...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199203000-00010

    authors: Tanaka J,Nomura M,Saito H

    更新日期:1992-03-01 00:00:00

  • Covert and overt orienting to gaze direction cues and the effects of fixation offset.

    abstract::We examined covert and overt orienting in response to non-predictive gaze direction cues and investigated whether the subcortical superior colliculus (SC) plays a role in this type of orienting. Participants viewed a centrally presented gazing schematic face and responded to targets appearing at gazed-at or non-gazed-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200303030-00039

    authors: Friesen CK,Kingstone A

    更新日期:2003-03-03 00:00:00

  • LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels.

    abstract::It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced b...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199811160-00022

    authors: Izumi Y,Zorumski CF

    更新日期:1998-11-16 00:00:00

  • Tau complexes with phospholipase C-gamma in situ.

    abstract::Based on the results of recent in vitro studies, tau has been proposed to be involved in regulating signal transduction through the phospholipase C-gamma (PLC-gamma) signaling pathway. The present study provides support for the physiological relevance of this hypothesis by demonstrating the existence of a tau-PLC-gamm...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199801050-00014

    authors: Jenkins SM,Johnson GV

    更新日期:1998-01-05 00:00:00

  • High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes.

    abstract::S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a neurotrophic role in neighboring cells. A protective role of the S100B against glutamate-induced excitotoxicity has recently been proposed. We investigated S100B secretion in rat hippocampal astrocytes exposed to high concentrations of ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200208270-00009

    authors: Gonçalves D,Karl J,Leite M,Rotta L,Salbego C,Rocha E,Wofchuk S,Gonçalves CA

    更新日期:2002-08-27 00:00:00

  • Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: an fMRI study.

    abstract::The temporal lobe regions involved in memory retrieval were examined using fMRI. During an associative recognition test, participants made memory judgments about the study color of previously presented drawings of objects, and during item recognition tests they made old/new judgments about previously studied objects o...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200102120-00035

    authors: Yonelinas AP,Hopfinger JB,Buonocore MH,Kroll NE,Baynes K

    更新日期:2001-02-12 00:00:00

  • Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice.

    abstract::Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water flux through the pericapillary (Virchow-Robin) space for both CSF production and reabsorption (Oreskovic and Klarica hypothesis), and challenge the classic CSF circulation theory, which proposes that CSF is primarily produced by ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000042

    authors: Igarashi H,Tsujita M,Kwee IL,Nakada T

    更新日期:2014-01-08 00:00:00

  • Semantic sentence processing reflected in the event-related potentials of one- and two-year-old children.

    abstract::The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000185013.98821.62

    authors: Friedrich M,Friederici AD

    更新日期:2005-11-07 00:00:00

  • Baclofen decreases methamphetamine self-administration in rats.

    abstract::In the present study we tested the hypothesis that baclofen, a GABA-B receptor agonist, attenuates methamphetamine self-administration. Fifteen rats were trained to self-administer i.v. injections of methamphetamine (0, 0.0625, 0.125 and 0.25 mg/kg/injection) on a progressive ratio schedule of reinforcement, and then ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200207020-00007

    authors: Ranaldi R,Poeggel K

    更新日期:2002-07-02 00:00:00

  • Automatic detection of lexical change: an auditory event-related potential study.

    abstract::We investigated the detection of rare task-irrelevant changes in the lexical status of speech stimuli. Participants performed a nonlinguistic task on word and pseudoword stimuli that occurred, in separate conditions, rarely or frequently. Task performance for pseudowords was deteriorated relative to words, suggesting ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f0ea16

    authors: Muller-Gass A,Roye A,Kirmse U,Saupe K,Jacobsen T,Schröger E

    更新日期:2007-10-29 00:00:00

  • Dorsal, but not ventral, hippocampal lesions disrupt cocaine place conditioning.

    abstract::The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200311140-00023

    authors: Meyers RA,Zavala AR,Neisewander JL

    更新日期:2003-11-14 00:00:00

  • Novel gene HCS1 is specifically expressed in the giant interneurones of the terrestrial snail.

    abstract::The terrestrial snail Helix lucorum is a promising model for molecular neurobiology since its central nervous system (CNS) is simple and contains many morphologically and functionally identified large neurones. Among these, the giant interneurones located in pleural and parietal ganglia are especially interesting beca...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199401000-00014

    authors: Bogdanov YD,Ovchinnikov DA,Balaban PM,Belyavsky AV

    更新日期:1994-01-31 00:00:00

  • GABAergic mechanisms gate tactile discrimination learning.

    abstract::In contrast to mechanisms mediating synaptic plasticity, the pharmacological basis of perceptual learning remains to be clarified. Here we report that a specific form of perceptual learning is influenced by GABAergic mechanisms. We induced perceptual learning by Hebbian co-activation of the skin of the tip of the righ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200309150-00018

    authors: Dinse HR,Ragert P,Pleger B,Schwenkreis P,Tegenthoff M

    更新日期:2003-09-15 00:00:00

  • Perception and recognition discriminated in the mouse auditory cortex by c-Fos labeling.

    abstract::The functions of the fields of the mammalian auditory cortex in sound perception and recognition are unknown. We used Fos (a protein of the inducible immediate-early gene c-fos) as a cellular marker of activated brain areas to show in the mouse (Mus domesticus) that sound is processed differentially in auditory cortic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908020-00022

    authors: Fichtel I,Ehret G

    更新日期:1999-08-02 00:00:00

  • Hippocampal function and visual object processing in temporal lobe epilepsy.

    abstract::Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from withi...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200308060-00017

    authors: Vannucci M,Dietl T,Pezer N,Viggiano MP,Helmstaedter C,Schaller C,Elger CE,Grunwald T

    更新日期:2003-08-06 00:00:00

  • Time course and specificity of event-related potentials to emotional expressions.

    abstract::To clarify the time course of neural responses to faces with different emotional expressions, we used event-related potential (ERP) and reaction time measures. Faces expressing four different emotions (happy, neutral, fearful, disgusted) and houses were shown in both upright and inverted orientations while subjects pe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200401190-00041

    authors: Ashley V,Vuilleumier P,Swick D

    更新日期:2004-01-19 00:00:00

  • CO2-sensitive medullary neurons: activation by intracellular acidification.

    abstract::Bioelectric activity of CO2-sensitive, ventrolateral medullary neurons (VLN(CS)) in organotypic cultures from the obex level of newborn rats was tested during changes of the intracellular pH (pHi) measured in BCECF-AM loaded cultures. Hypercapnia (pCO2 80-100 mmHg) reduced pHi by 0.15 +/- 0.06 units and stimulated neu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199801050-00034

    authors: Wiemann M,Baker RE,Bonnet U,Bingmann D

    更新日期:1998-01-05 00:00:00

  • Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line.

    abstract::Subpopulations of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199710200-00001

    authors: Puche AC,Bartlett PF,Key B

    更新日期:1997-10-20 00:00:00

  • Within- and between-channel gap detection in the human auditory cortex.

    abstract::We examined the neural correlates associated with a short gap between two identical pure tones (within-channel) and between two different tones (between-channel) in an odd-ball paradigm. Gap durations were selected such that a gap between identical tones was as discriminable as a gap between two different tones. Spati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200409150-00011

    authors: Heinrich A,Alain C,Schneider BA

    更新日期:2004-09-15 00:00:00

  • Changes in spinal cholecystokinin release after peripheral axotomy.

    abstract::The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200101220-00018

    authors: Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

    更新日期:2001-01-22 00:00:00

  • Long-term potentiation in the perirhinal-hippocampal pathway is NMDA dependent.

    abstract::The putative memory mechanism known as long-term potentiation (LTP) has been described in both NMDA-dependent and non-NMDA-dependent forms. The aim of the present study was to determine which of these forms described the LTP generated between perirhinal cortex (PRC) and hippocampus, two structures which have previousl...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199605170-00003

    authors: Liu P,Bilkey DK

    更新日期:1996-05-17 00:00:00

  • Maternal nicotine exposure enhances cutaneous axon reflexes in the neonatal rat.

    abstract::Chronic nicotine exposure enhances axon reflexes in adult rats. Since smoking mothers expose their infants to nicotine, this study investigated whether late gestational and or lactational maternal nicotine exposure affects neonatal axon reflexes. Osmotic pumps, implanted subcutaneously in adult female rats, delivered ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199306000-00008

    authors: Grunfeld JA,Tiedemann GJ,Westerman RA

    更新日期:1993-06-01 00:00:00

  • Requirement of the auditory association cortex for discrimination of vowel-like sounds in rats.

    abstract::We investigated the roles of the auditory cortex in discrimination learning of vowel-like sounds consisting of multiple formants. Rats were trained to discriminate between synthetic sounds with four formants. Bilateral electrolytic lesions including the primary auditory cortex and the dorsal auditory association corte...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32800fef9d

    authors: Kudoh M,Nakayama Y,Hishida R,Shibuki K

    更新日期:2006-11-27 00:00:00

  • Induction of the Zenk protein after sexual interactions in male Japanese quail.

    abstract::We mapped cells immunoreactive (ir) for the protein encoded by the immediate early gene zenk in the brains of male Japanese quail after they engaged in either appetitive or consummatory sexual behavior (i.e. copulation). Castrated males treated with testosterone were either allowed to copulate with a female or exhibit...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199709080-00032

    authors: Ball GF,Tlemçani O,Balthazart J

    更新日期:1997-09-08 00:00:00

  • The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices.

    abstract::Hypoxia-induced changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was ma...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199805110-00031

    authors: Staunton M,Dulitz MG,Fang C,Schmeling WT,Kampine JP,Farber NE

    更新日期:1998-05-11 00:00:00

  • Time course of brain activation elicited by basic emotions.

    abstract::Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of br...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000016

    authors: Hot P,Sequeira H

    更新日期:2013-11-13 00:00:00

  • Activity in the human primary motor cortex related to arm and finger movements.

    abstract::With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199501000-00003

    authors: Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Yanagisawa T

    更新日期:1995-01-26 00:00:00

  • Insights into brain function through the examination of art: the influence of neurodegenerative diseases.

    abstract::There has been intense interest in determining how the visual brain processes the outside world, and in identifying the neuroanatomical correlates of the ability to create art. Comparing art production before and after illness onset permits some speculation on the function of selective brain regions affected by the ne...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/00001756-200404290-00001

    authors: Kleiner-Fisman G,Lang AE

    更新日期:2004-04-29 00:00:00

  • Persistence of CA1 hippocampal LTP after selective cholinergic denervation.

    abstract::The possible role of endogenous cholinergic innervation in hippocampal plasticity is controversial. We studied the role of acetylcholine (ACh) in short- and long-term potentiation (STP and LTP), using the cholinergic neurotoxin 192 IgG-saporin. It was still possible to induce STP the LTP in the CA1 field following com...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199603220-00024

    authors: Jouvenceau A,Billard JM,Lamour Y,Dutar P

    更新日期:1996-03-22 00:00:00