Abstract:
:Bioelectric activity of CO2-sensitive, ventrolateral medullary neurons (VLN(CS)) in organotypic cultures from the obex level of newborn rats was tested during changes of the intracellular pH (pHi) measured in BCECF-AM loaded cultures. Hypercapnia (pCO2 80-100 mmHg) reduced pHi by 0.15 +/- 0.06 units and stimulated neuronal discharges. Replacement of CO2/HCO3- in the bath by HEPES (26 mM, pH 7.4) for 10 min acidified pHi (0.07 +/- 0.03 units) and also excited VLN(CS). Ammonium chloride (10 mM, 1 min) initially alkalized (0.1 +/- 0.04) and thereafter acidified pHi (0.06 +/- 0.03), while the extracellular pH was first acidified and then alkalized. This resulted in neuronal discharge which were first suppressed and then accelerated. The findings strongly suggest that intracellular rather than extracellular acidification activates CO2-sensitive neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wiemann M,Baker RE,Bonnet U,Bingmann Ddoi
10.1097/00001756-199801050-00034subject
Has Abstractpub_date
1998-01-05 00:00:00pages
167-70issue
1eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Pulmonary slowly adapting receptors (SARs) and rapidly adapting receptors (RARs) are important components of various respiratory reflexes. In anesthetized, paralyzed and artificially ventilated rats, we found an inhibitory linkage from the former to the latter system at the level of their second-order relay neurons (P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006050-00023
更新日期:2000-06-05 00:00:00
abstract::Müller cells, as the predominant glial element in the sensory retina, play a crucial role in healthy and diseased retina. Overactivation of Müller cells in response to damage is detrimental to the retina tissue. Current research shows that inhibiting glial fibrillary acidic protein (GFAP), a sensitive indicator of Mül...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001143
更新日期:2018-12-05 00:00:00
abstract::To test the effect of nitric oxide synthase (NOS) blockade on the ventilatory responses to carotid body chemoreceptor stimulation in freely behaving animals, chronically instrumented adult Sprague-Dawley rats received increasing intravenous doses of sodium cyanide (NaCN; 0-300 micrograms kg-1) before and after i.v. ad...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604260-00009
更新日期:1996-04-26 00:00:00
abstract::To investigate the implications of duration of deafness in the rehabilitation of unilateral deafness utilizing cochlear implantation. From the ongoing prospective cochlear implantation in unilateral deafness study, we looked at five adults who received a cochlear implant for long-term unilateral deafness. Speech perce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283642a93
更新日期:2013-09-11 00:00:00
abstract::Salidroside (SDS), a phenylpropanoid glycoside isolated from Rhodiola rosea L., has been reported to be neuroprotective in vitro, which raises the possibility of using SDS as a neuroprotective agent after nerve injuries. In the present study, the possibly beneficial effect of SDS on promoting nerve regeneration after ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835eb867
更新日期:2013-03-27 00:00:00
abstract::Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXS...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00021
更新日期:2002-12-03 00:00:00
abstract::In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00011
更新日期:2001-04-17 00:00:00
abstract::The ventral cochlear tract in the brain stem to pons was transected on one side in two groups of adult rats. In one group simple transection was performed, while in the other group tissue from embryos (E14-E16) was used to cover the lesion site. While rats receiving simple transection without transplantation showed no...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00009
更新日期:1998-12-01 00:00:00
abstract::Static and dynamic contrast sensitivities (sCS and dCS) were evaluated before, during, immediately after and 10 min after anodal and cathodal transcranial direct current stimulation (tDCS) applied to the occipital cortex of 15 healthy subjects. Using 4 c/d spatial and 4 Hz temporal frequencies significant sCS and dCS ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200111160-00036
更新日期:2001-11-16 00:00:00
abstract::Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000071
更新日期:2013-12-18 00:00:00
abstract:OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001582
更新日期:2021-01-18 00:00:00
abstract::The aim of this study was to investigate the effects of congenital human cytomegalovirus infection on the expression levels of N-methyl-D-aspartate receptors (NRs) and Ca/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal neurons of neonatal Sprague-Dawley (SD) rats. Pregnant SD rats were divided into ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000750
更新日期:2017-03-22 00:00:00
abstract::Inflammatory and immune responses are known to be involved in the pathogenesis of Alzheimer's disease (AD). NF-kappaB is a major transcription factor that plays a central role in the inflammatory and immune responses and is regulated by I-kappaB through an autoregulatory feedback system. Southwestern immunohistochemis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108280-00011
更新日期:2001-08-28 00:00:00
abstract::We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00023
更新日期:2002-05-07 00:00:00
abstract::The current study aimed to investigate the altered cerebellar-cerebral functional connectivity (FC) induced by radiotherapy to nasopharyngeal carcinoma (NPC) patients. Twenty-four NPC patients without treatment, and 35 NPC patients receiving radiotherapy underwent functional MRI scanning. Montreal cognitive assessment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000813
更新日期:2017-08-16 00:00:00
abstract::Alpha-Synuclein is a major component of neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA), one of the alpha-synucleinopathies. Recent studies have shown that beta-synuclein, a homolog of alpha-synuclein, inhibits alpha-synuclein aggregation in vitro. We immunohistochemically examined the MSA b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00005
更新日期:2003-10-06 00:00:00
abstract::All-night recordings of respiration, ballistocardiogram, and body movements were obtained using the static charge-sensitive bed (SCSB) and automatically analysed data were compared with sleep stages. The mean sum of eight SCSB variability parameters was lowest in slow wave sleep (SWS), higher during stage 2 (S2), and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604100-00030
更新日期:1996-04-10 00:00:00
abstract:OBJECTIVE:The traditional Chinese medicine, Dendrobium nobile Lindl. polysaccharides (DNLP), reportedly has neuroprotective effects. However, its effects following ischemic stroke remain unclear. This study aimed to explore the role and mechanism of DNLP in experimental models of inflammation and apoptosis. METHODS:In...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001562
更新日期:2020-12-14 00:00:00
abstract::The survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00021
更新日期:1998-05-11 00:00:00
abstract::We measured regional cerebral blood flow using positron emission tomography in seven normal volunteers during discrimination tasks for visual patterns. For the 'attention to right or left' tasks, the subjects were instructed to press a key when sample and test stimuli presented in the right or left visual fields, resp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00060
更新日期:1998-05-11 00:00:00
abstract::We have investigated the hypothesis that the acute ischemic swelling of the radial dendrites connected to the inner hair cells (IHCs) is mediated by glutamatergic receptors. In control cochleas, after 20 min ischemia all the dendrites were dramatically swollen. Conversely, after a perfusion of 50 microM 6-7-dinitroqui...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00002
更新日期:1992-04-01 00:00:00
abstract::Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001451
更新日期:2020-05-22 00:00:00
abstract::Regional brain activity associated with intentional and incidental memory retrieval was studied with PET. Previously studied and new words were presented in either an intentional or an incidental memory task. Type of task was crossed with an encoding manipulation ('deep' vs 'shallow') which varied the probability that...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199703240-00045
更新日期:1997-03-24 00:00:00
abstract::A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00015
更新日期:2001-02-12 00:00:00
abstract::Axonal atrophy may reflect earlier and more reversible events in neurodegeneration and ageing than somatic atrophy. Innervation density by sympathetic fibres from the rat superior cervical ganglion (SCG) to the middle cerebral artery (MCA) decreases dramatically in old age, while that to the iris is largely unchanged....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00044
更新日期:1997-02-10 00:00:00
abstract::Using cRNA in situ hybridization, the regional distribution of mRNA encoding the human Y1 receptor was investigated in the normal human brain and compared with the autoradiographic distribution of putative Y1/[125I][Leu31,Pro34]PYY binding sites. Surprisingly, relatively high levels of Y1 receptor mRNA, distributed in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604100-00020
更新日期:1996-04-10 00:00:00
abstract::Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis (ALS), yet it remains unclear why some groups of motoneurons (MNs) are more vulnerable to degeneration than others. Our aim was to compare, in normal adult rats, the expression of Group I metabotropic glutamate receptors (mGluR...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00027
更新日期:2001-07-03 00:00:00
abstract::Using functional magnetic resonance imaging (fMRI), we investigated whether the response of auditory and visual cortex was modulated by attending selectively to either heard or seen numbers presented simultaneously. Alternating attention between modalities modulated fMRI signal within the corresponding sensory cortex....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199608120-00007
更新日期:1996-08-12 00:00:00
abstract::Diffusion tensor imaging is a new in vivo tool not only for the assessment of white matter structural integrity but also for diagnosis and assessment of disease conditions which disturb tissue structural coherence. In this study, we investigated the integrity of auditory pathway in patients of sensorineural hearing lo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000134584.10207.1a
更新日期:2004-08-06 00:00:00
abstract::Neural progenitor/stem cells reside in the subventricular zone and dentate gyrus of the adult rat brain, which proliferate in response to several growth factors. Here we show that the neurospheres generated from the adult dentate gyrus and subventricular zone proliferate in vitro in response to fibroblast growth facto...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505310-00011
更新日期:2005-05-31 00:00:00