Regeneration of the auditory pathway in adult rats by transplants of fetal brain tissue.

Abstract:

:The ventral cochlear tract in the brain stem to pons was transected on one side in two groups of adult rats. In one group simple transection was performed, while in the other group tissue from embryos (E14-E16) was used to cover the lesion site. While rats receiving simple transection without transplantation showed no evidence of regeneration, in 30% of the rats receiving transplants of embryonic tissue the axons regrew beyond the transected site and regenerated into the denervated side and terminated at the normal targets. The present findings contradict the widely held view that the adult mammalian central auditory system cannot be restored following damage.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Ito J,Kawaguchi S,Murata M

doi

10.1097/00001756-199812010-00009

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

3815-7

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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