192 IgG-saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN.

Abstract:

:The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75NTR and VIP immunoreactivity in the rat SCN. The 192 IgG-saporin immunotoxin abolished p75NTR immunoreactivity in the SCN. VIP immunoreactivity in the SCN of saporin-lesioned animals was not significantly different from that of control animals. Immunolesions of the p75NTR-ir cell population in the SCN may prove useful in clarifying the role of p75NTR in circadian timing.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Moga MM

doi

10.1097/00001756-199810050-00012

subject

Has Abstract

pub_date

1998-10-05 00:00:00

pages

3197-200

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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