Abstract:
:The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75NTR and VIP immunoreactivity in the rat SCN. The 192 IgG-saporin immunotoxin abolished p75NTR immunoreactivity in the SCN. VIP immunoreactivity in the SCN of saporin-lesioned animals was not significantly different from that of control animals. Immunolesions of the p75NTR-ir cell population in the SCN may prove useful in clarifying the role of p75NTR in circadian timing.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Moga MMdoi
10.1097/00001756-199810050-00012subject
Has Abstractpub_date
1998-10-05 00:00:00pages
3197-200issue
14eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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