Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes.

abstract：:The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation, nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p5...

journal_title：Neuroreport

authors： Zhou J,Fu Y,Tang XC

更新日期：2001-07-20 00:00:00

abstract：:Plasminogen activator inhibitor-1 is a serpin that regulates the activities of plasminogen activators. However, its physiological roles in the CNS are incompletely understood. We have found that plasminogen activator inhibitor-1 has a novel biological function in the CNS: the contribution to survival of neurites on ne...

journal_title：Neuroreport

authors： Soeda S,Imatoh T,Ochiai T,Koyanagi S,Shimeno H

更新日期：2004-04-09 00:00:00

abstract：:The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 an...

journal_title：Neuroreport

authors： Tellam DJ,Perone MJ,Dunn IC,Radovick S,Brennand J,Rivier JE,Castro MG,Lovejoy DA

更新日期：1998-10-05 00:00:00

abstract：:Previous event-related potential studies in Indo-European languages reported a surprising finding that failed syntactic category processing appears to block lexical-semantic integration, suggesting a functional primacy of syntax over semantics. An event-related potential experiment was conducted to test whether there ...

journal_title：Neuroreport

authors： Yu J,Zhang Y

更新日期：2008-05-07 00:00:00

abstract：:Recent studies have demonstrated a loss of cannabinoid CB1 receptors in the basal ganglia in Huntington's disease (HD), but there are no data on endocannabinoid levels in this disease. In the present study, we have addressed this question by using rats with bilateral intrastriatal injections of 3-nitropropionic acid (...

journal_title：Neuroreport

authors： Lastres-Becker I,Fezza F,Cebeira M,Bisogno T,Ramos JA,Milone A,Fernández-Ruiz J,Di Marzo V

更新日期：2001-07-20 00:00:00

abstract：:Humans afflicted with mood disorders respond differently to antidepressant drug therapy. Different responses to psychoactive drugs are also observed in rats, and specific strains exhibit substantial differences in gene expression following synaptic activity. We examined the effects of fluoxetine on the induction of Fo...

journal_title：Neuroreport

authors： Horowitz JM,Hallas BH,Torres G

更新日期：2002-12-20 00:00:00

abstract：:We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...

journal_title：Neuroreport

authors： Abe S,Mizusawa I,Kanno K,Yabashi A,Suto M,Kuraya M,Honda T,Hiraiwa K

更新日期：2003-12-02 00:00:00

abstract：:The death of spinal motoneurones after axotomy provides a useful model for studying novel factors which prevent motoneurone loss in vivo. Peripheral nerves of newborn rats were unilaterally transected and treated with either a vehicle solution or leukaemia inhibitory factor (LIF). Compared with the vehicle controls, t...

journal_title：Neuroreport

authors： Cheema SS,Richards LJ,Murphy M,Bartlett PF

更新日期：1994-04-14 00:00:00

abstract：:The neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Recently it has been reported that the entire coding region of VAChT mRNA is located in the first intron of the ChAT gene. In this study, ChAT...

journal_title：Neuroreport

authors： Misawa H,Takahashi R,Deguchi T

更新日期：1995-05-09 00:00:00

abstract：:The rat synaptosomal membrane antigen D3, which has been studied for more than 20 years since its first demonstration as a brain-specific protein, was shown to bind monoclonal antibodies to SNAP-25, a presynaptic plasma membrane-associated protein. In addition to SNAP-25, anti-D3 antiserum also precipitated two polype...

journal_title：Neuroreport

authors： Jørgensen OS

更新日期：1995-12-29 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenolic extract in green tea and it has attracted increasing attention for its multiple bioactive effects. However, the mechanisms by which EGCG exerts its neuroprotective actions in Alzheimer's disease (AD) are presently lacking. In the present study, a ...

journal_title：Neuroreport

authors： Guo Y,Zhao Y,Nan Y,Wang X,Chen Y,Wang S

更新日期：2017-07-05 00:00:00

abstract：:Modulation of the soleus H-reflex following galvanic vestibular stimulation (GVS) has been used to evaluate vestibulospinal tract function. It is not known whether this modulation is because of vestibular stimulation and/or cutaneous stimulation, and the suitable stimulating intensity of GVS for the modulation is not ...

journal_title：Neuroreport

authors： Okada Y,Shiozaki T,Nakamura J,Azumi Y,Inazato M,Ono M,Kondo H,Sugitani M,Matsugi A

更新日期：2018-09-05 00:00:00

abstract：:Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus...

journal_title：Neuroreport

authors： Jang Y

更新日期：2020-04-08 00:00:00

abstract：:The current study examined the hemodynamic response during the Go/NoGo task in children with/without attention deficit/hyperactivity disorder (ADHD). Using near-infrared spectroscopy, oxy-Hb and deoxy-Hb concentration changes in the frontal areas were compared during the conditions with/without inhibitory demand. Comp...

journal_title：Neuroreport

authors： Inoue Y,Sakihara K,Gunji A,Ozawa H,Kimiya S,Shinoda H,Kaga M,Inagaki M

更新日期：2012-01-25 00:00:00

abstract：:Two [O(15)] PET studies assessed sex differences regional brain activation in the recognition of emotional stimuli. Study I revealed that the recognition of emotion in visual faces resulted in bilateral frontal activation in women, and unilateral right-sided activation in men. In study II, the complexity of the emotio...

journal_title：Neuroreport

authors： Hall GB,Witelson SF,Szechtman H,Nahmias C

更新日期：2004-02-09 00:00:00

abstract：:Using NADPH-diaphorase (NADPH-d) staining as a marker for the enzyme nitric oxide synthase (NOS) we investigated the possible sites of nitric oxide (NO) synthesis in the olfactory pathways of an insect brain. Staining of frozen sections revealed NADPH-d activity in neurones and in glial cells. A cluster of intensely s...

journal_title：Neuroreport

authors： Bicker G,Hähnlein I

更新日期：1995-01-26 00:00:00

abstract：:Three adult Japanese monkeys (M. fuscata: body weights 4.5-8.5 kg) were trained to walk quadrupedally on a surface of a moving treadmill (walking length and width: 150 cm and 60 cm, treadmill speed: 0.4-1.7 m s-1. At any different constant treadmill velocity, the monkeys exhibited a diagonal pattern of locomotor movem...

journal_title：Neuroreport

authors： Mori S,Miyashita E,Nakajima K,Asanome M

更新日期：1996-10-02 00:00:00

abstract：:The time-dependent effect of transcranial direct current stimulation (tDCS) on working memory was investigated by applying anodal stimulation over the left prefrontal cortex. This single-blind, sham-controlled crossover study recruited 15 healthy participants. A three-back verbal working-memory task was performed befo...

journal_title：Neuroreport

authors： Ohn SH,Park CI,Yoo WK,Ko MH,Choi KP,Kim GM,Lee YT,Kim YH

更新日期：2008-01-08 00:00:00

abstract：:Hypoxia or global ischemia causes rapid loss of consciousness and a sudden increase in spontaneous transmitter release suggesting that coordinated synaptic activity is impaired. Gamma oscillations (30-100 Hz) are thought to provide for binding of parallel processed information in the brain, contributing to cognition a...

journal_title：Neuroreport

authors： Fano S,Behrens CJ,Heinemann U

更新日期：2007-11-19 00:00:00

abstract：:The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

journal_title：Neuroreport

authors： Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

更新日期：2001-01-22 00:00:00

abstract：:The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements reveal...

journal_title：Neuroreport

authors： Salas C,Navarro F,Torres B,Delgado-Garcia JM

更新日期：1992-02-01 00:00:00

abstract：:Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg mo...

journal_title：Neuroreport

authors： Sharpe LG,Jaffe JH

更新日期：1990-09-01 00:00:00

abstract：:Sensory funneling of liminal multiple-point air-puff stimulation on the skin was evaluated by measuring somatosensory evoked potentials (SEPs), reaction time (RT) and subjective detection threshold. Single-point air-puffs at the threshold intensity, and 2-point and 3-point air-puffs (10 mm apart) of the same intensity...

journal_title：Neuroreport

authors： Hashimoto I,Yoshikawa K,Kimura T

更新日期：1999-10-19 00:00:00

abstract：:The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, ...

journal_title：Neuroreport

authors： Horschitz S,Hummerich R,Schloss P

更新日期：2001-07-20 00:00:00

abstract：:GABAA receptors mediate the inhibition of somatostatin release in hypothalamic neurones. To study the possible effect of GABA on somatostatin biosynthesis, somatostatin and preprosomatostatin mRNA levels were evaluated after exposure of hypothalamic neurones to muscimol or bicuculline. Muscimol (50 microM) decreased p...

journal_title：Neuroreport

authors： Rage F,Jalaguier S,Rougeot C,Tapia-Arancibia L

更新日期：1993-03-01 00:00:00

abstract：:The majority of retinal ganglion cells innervating the suprachiasmatic nucleus are intrinsically light sensitive, while the rest are conventional ganglion cells that collect inputs through conventional photoreceptors. Here we report a rarely encountered ganglion cell that had a dendritic field covering approximately 1...

journal_title：Neuroreport

authors： Pu M,Chen B,Li RS,Tay D,So KF

更新日期：2006-10-02 00:00:00

abstract：:To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan...

journal_title：Neuroreport

authors： Funayama M,Li Y,Tomiyama H,Yoshino H,Imamichi Y,Yamamoto M,Murata M,Toda T,Mizuno Y,Hattori N

更新日期：2007-02-12 00:00:00

abstract：:Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...

journal_title：Neuroreport

authors： Tsurugizawa T,Kondoh T,Torii K

更新日期：2008-07-16 00:00:00

abstract：:We investigated the spatio-temporal brain activity on the time scale of several milliseconds related to the mental rotation task requiring judgements of hand orientation, using a whole-cortex MEG (magnetoencephalography) system. Neuronal activity in the visual cortex was observed approximately 100-200 ms from stimulus...

journal_title：Neuroreport

authors： Kawamichi H,Kikuchi Y,Endo H,Takeda T,Yoshizawa S

更新日期：1998-04-20 00:00:00

abstract：:Three SNARE proteins, SNAP-25, syntaxin 1A, and VAMP2 or synaptobrevin 2, constitute the minimal functional machinery needed for the regulated secretion of neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are associated with the induction of long-term plasticity at central synapses. In-...

journal_title：Neuroreport

authors： Irfan M,Zurawski Z,Hamm HE,Bark C,Stanton PK

更新日期：2019-07-03 00:00:00