Effects of adrenalectomy on hyperphagia induced by the 5-HT1A receptor agonist 8-OH-DPAT and 2-deoxy-D-glucose in rats.

Abstract:

:Effects of adrenalectomy on the 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)- and 2-deoxy-D-glucose (2-DG)-induced hyperphagia were investigated in rats. Prior adrenalectomy completely inhibited 2-DG-induced hyperphagia, although it did not affect increases in food intake elicited by 8-OH-DPAT. These results suggest that 8-OH-DPAT-induced hyperphagia is independent of the adrenal hormone, corticosterone while 2-DG-induced hyperphagia is closely related to corticosterone.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Yamada J,Sugimoto Y,Yoshikawa T

doi

10.1097/00001756-199806010-00030

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

1831-3

issue

8

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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