Interleukin-1 beta is involved in the pressor response of amygdaloid neurons excited by sodium glutamate.

Abstract:

:The effects of interleukin-1beta in the paraventricular nucleus or caudal arcuate nucleus on hypertensive and tachycardiac responses induced by excitation of the central amygdaloid nucleus were studied. We observed that microinjection of sodium glutamate into central amygdaloid nucleus resulted in hypertension and tachycardia. Microinjection of interleukin-1beta into paraventricular nucleus or caudal arcuate nucleus induced significant pressor and tachycardiac responses while pretreatment with microinjection of rabbit anti-rat interleukin-1beta antibody into bilateral paraventricular nuclei or arcuate nuclei attenuated the hypertensive response induced by microinjection of 40 nmol sodium glutamate into central amygdaloid nucleus. The above results suggest that the pressor effect of central amygdaloid nucleus is mediated by interleukin-1beta in paraventricular nucleus or arcuate nucleus.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Lu Y,Chen W,Zou CJ

doi

10.1097/00001756-200203250-00039

subject

Has Abstract

pub_date

2002-03-25 00:00:00

pages

559-62

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

13

pub_type

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