Abstract:
:The effects of interleukin-1beta in the paraventricular nucleus or caudal arcuate nucleus on hypertensive and tachycardiac responses induced by excitation of the central amygdaloid nucleus were studied. We observed that microinjection of sodium glutamate into central amygdaloid nucleus resulted in hypertension and tachycardia. Microinjection of interleukin-1beta into paraventricular nucleus or caudal arcuate nucleus induced significant pressor and tachycardiac responses while pretreatment with microinjection of rabbit anti-rat interleukin-1beta antibody into bilateral paraventricular nuclei or arcuate nuclei attenuated the hypertensive response induced by microinjection of 40 nmol sodium glutamate into central amygdaloid nucleus. The above results suggest that the pressor effect of central amygdaloid nucleus is mediated by interleukin-1beta in paraventricular nucleus or arcuate nucleus.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Lu Y,Chen W,Zou CJdoi
10.1097/00001756-200203250-00039subject
Has Abstractpub_date
2002-03-25 00:00:00pages
559-62issue
4eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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