Abstract:
:Evidence exists that motilin immunoreactivity is highly expressed in Purkinje cells. In this study, immunohistochemistry and whole-cell patch-clamp recording were performed to investigate the spatial distribution and electrophysiological effects of motilin receptors in the cerebellum. We show here that motilin receptors are strongly expressed in Purkinje cells of the human and rat cerebellum. Motilin at 10 nM depolarized Purkinje cells of the rat cerebellum, and this was mimicked by the motilin receptor agonist erythromycin. The depolarization evoked by motilin persisted in the presence of tetrodotoxin, glutamate and gamma-amino-n-butyric acid receptor antagonists, indicating that motilin excited the Purkinje cells by activating the receptor expressed on the neurons recorded. We suggest that motilin may serve specific neural functions in the cerebellum.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Chen H,Chen L,Wang JJ,Wei HJ,Yung WHdoi
10.1097/WNR.0b013e328273bc98subject
Has Abstractpub_date
2007-08-27 00:00:00pages
1345-9issue
13eissn
0959-4965issn
1473-558Xpii
00001756-200708270-00009journal_volume
18pub_type
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