Abstract:
:Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) receptor-mediated inhibitory postsynaptic currents (IPSCs) in dopamine neurons of the substantia nigra pars compacta of 6 to 15-day-old rats. In slices, MANF increased the amplitude of evoked IPSCs and decreased the paired pulse ratio. In mechanically dissociated cells, MANF increased the frequency of spontaneous and miniature IPSCs, without changing their mean amplitudes; and in enzymatically dissociated neurons, MANF had no effect on currents induced by exogenous GABA. The presynaptic enhancement of GABAergic inhibition may contribute to MANF's protective action on dopamine cells.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Zhou C,Xiao C,Commissiong JW,Krnjević K,Ye JHdoi
10.1097/01.wnr.0000201504.23255.bcsubject
Has Abstractpub_date
2006-02-27 00:00:00pages
293-7issue
3eissn
0959-4965issn
1473-558Xpii
00001756-200602270-00013journal_volume
17pub_type
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