Abstract:
:The present study examined the distribution in the human spinal cord of a unique carboxy terminus sequence contained within MOR-1C, one of the recently described splice variants of the cloned mu opioid receptor gene MOR-1. Although MOR-1-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were observed only in the superficial laminae, MOR-1C-LI was abundant in the superficial laminae of the dorsal horn and around the central canal. In the substantia gelatinosa, MOR-1C-LI was found in small diameter axonal elements, the cytoplasm and the plasmalemma of small spinal neurons and dendrites in inner lamina II and in some fibers within Lissauer's tract. These studies imply the presence of MOR-1C in human spinal cord and its distribution suggests that it plays a role in the control of pain processing.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Abbadie C,Gultekin SH,Pasternak GWdoi
10.1097/00001756-200006260-00029subject
Has Abstractpub_date
2000-06-26 00:00:00pages
1953-7issue
9eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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