Abstract:
:Hydroxyindole-O-methyltransferase (HIOMT), is the last enzyme of the melatonin biosynthesis pathway. We have applied immunocytochemistry and in situ hybridization to localize HIOMT producing cells, in the chicken epithalamus including the pineal gland. The selectivity of the hybridization signal over melatoninergic cells was ascertained by comparison with the immunolabelling. HIOMT transcripts could be observed in the two cell layers of the pineal follicles and in the pineal stalk, but not in other epithalamic regions. These results indicate that pineal modified photoreceptors and parafollicular pinealocyte-like cells represent the two populations of melatonin-producing cells of the chicken epithalamus.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Grève P,Bernard M,Voisin P,Cogné M,Collin JP,Guerlotte Jdoi
10.1097/00001756-199306000-00052subject
Has Abstractpub_date
1993-06-01 00:00:00pages
803-6issue
6eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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