D600, a Ca2+ antagonist, prevents stimulation of nerve regeneration by magnetic fields.

Abstract:

:We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmotic minipumps. Magnetic field exposure increased regeneration distances in vehicle perfused nerves. This enhancement was blocked by perfusion with D600 at a concentration which alone failed to affect outgrowth of nerve fibres, lending support to the idea that Ca2+ fluxes could be involved in mediating the biological actions of magnetic fields.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Rusovan A,Kanje M

doi

10.1097/00001756-199209000-00023

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

813-4

issue

9

eissn

0959-4965

issn

1473-558X

journal_volume

3

pub_type

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