A novel animal model of acute cochlear mitochondrial dysfunction.

abstract：:The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...

journal_title：Neuroreport

authors： Favaron M,Manev RM,Rimland JM,Candeo P,Beccaro M,Manev H

更新日期：1993-09-03 00:00:00

abstract：:In order to investigate GABA uptake into Müller glial cells electrophysiologically, we used the whole-cell voltage-clamp technique. Since Müller cells were insensitive to application of muscimol and baclofen, the expression of GABAA and GABAB receptors can be excluded. Therefore, the observed GABA current must be due ...

journal_title：Neuroreport

authors： Biedermann B,Eberhardt W,Reichelt W

更新日期：1994-01-12 00:00:00

abstract：:Differences related to development were investigated using a finger isometric force task in children with cerebral palsy and control children. The increase in force and force control observed in controls did not take place in patients. In the younger subset of patients (< 10 years) the force produced by the non-affect...

journal_title：Neuroreport

authors： Smits-Engelsman BC,Rameckers EA,Duysens J

更新日期：2004-08-26 00:00:00

abstract：:Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...

journal_title：Neuroreport

authors： Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer P

更新日期：2008-07-16 00:00:00

abstract：:Removal of the labyrinthine organs on one side results in static and dynamic disturbances. Some functional recovery occurs over time and is paralleled in frogs by an increase in the efficacy of central vestibular pathways. Here, we report concomitant increases in dorsal root evoked ventral root responses in the brachi...

journal_title：Neuroreport

authors： Straka H,Kunkel A,Dieringer N

更新日期：1993-09-01 00:00:00

abstract：:The cochlea can be protected from acoustic trauma by moderate-level sound exposure. It is suggested that olivocochlear system may play a significant role in this protection. This study was performed to investigate distortion product otoacoustic emission (DPOAE) amplitudes changes and the efficiency of contralateral no...

journal_title：Neuroreport

authors： Peng JH,Tao ZZ,Huang ZW

更新日期：2007-07-16 00:00:00

abstract：:Although the self-referential effect was widely supported by several previous studies, there was few event-related potential (ERP) evidence for the encoding mechanism of the self-referential effect. The present study employed ERPs to investigate whether the electrophysiological indices of the encoding processing could...

journal_title：Neuroreport

authors： Yang X,Mao X,Han M,Li X,Guo C

更新日期：2019-09-04 00:00:00

abstract：:This study examined the long-term effects of the antidepressant escitalopram on rat serotonin (5-HT) neuronal activity and hippocampal neuroplasticity. In the dorsal raphe nucleus, a 2-week treatment with escitalopram (10 mg/kg/day, subcutaneous) did not modify the firing activity of 5-HT neurons, whereas a cotreatmen...

journal_title：Neuroreport

authors： Mnie-Filali O,Faure C,Mansari ME,Lambás-Señas L,Bérod A,Zimmer L,Sánchez C,Haddjeri N

更新日期：2007-10-08 00:00:00

abstract：:Newly hatched domestic chicks serve as an important model for experimental studies of neural and behavioral plasticity. Brain-derived neurotrophic factor (BDNF) has been shown to play a critical role in synaptic plasticity, including long-term potentiation, which underlies learning and memory in rodents. Here we show ...

journal_title：Neuroreport

authors： Yamaguchi S,Aoki N,Kobayashi D,Kitajima T,Iikubo E,Katagiri S,Matsushima T,Homma KJ

更新日期：2011-12-07 00:00:00

abstract：:In an attempt to determine whether small focal malformations of the neocortex can be visualized in vivo, focal microgyria were induced in the neocortex of otherwise normal rats by freezing injury to the developing cortical plate, and in adulthood the malformation was visualized using MRI. Induced microgyria of varying...

journal_title：Neuroreport

authors： Rosen GD,Burstein D

更新日期：1997-12-22 00:00:00

abstract：:As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...

journal_title：Neuroreport

authors： Sanchez-Alavez M,Criado JR,Klein I,Moroncini G,Conti B

更新日期：2008-10-08 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are implicated in the pathological changes observed in the diabetic central nervous system. In this study, using the streptozotocin-induced diabetic rat model we document for the first time the over-expression of a mitochondrial specific stress protein (chaperonin 60) in ...

journal_title：Neuroreport

authors： Yuan J,Young BJ,Martinus RD

更新日期：2006-02-27 00:00:00

abstract：:The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...

journal_title：Neuroreport

authors： Friedrich M,Friederici AD

更新日期：2005-11-07 00:00:00

abstract：:We investigated the influence of gravity on the maturation of electrical properties of lumbar motoneurons and the development of their inputs from ventral descending pathways, which are important for the control of posture and locomotion. Using electrophysiological approaches in the in vitro brain stem-spinal cord pre...

journal_title：Neuroreport

authors： Brocard F,Clarac F,Vinay L

更新日期：2003-09-15 00:00:00

abstract：:In order to accomplish desired movements, the nervous system must specify the movement dynamics: it must provide a signal that compensates for the mechanical constraints encountered during movement. Here we tested whether the population activity of Purkinje cells in the cerebellum specifies the dynamics for pursuit ey...

journal_title：Neuroreport

authors： Krauzlis RJ

更新日期：2000-04-07 00:00:00

abstract：:The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...

journal_title：Neuroreport

authors： Yamada K,Sakai K,Akazawa K,Yuen S,Sugimoto N,Sasajima H,Mineura K,Nishimura T

更新日期：2010-09-15 00:00:00

abstract：:In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...

journal_title：Neuroreport

authors： Comelli MC,Seren MS,Guidolin D,Manev RM,Favaron M,Rimland JM,Canella R,Negro A,Manev H

更新日期：1992-06-01 00:00:00

abstract：:In this study, we ask whether or not the involuntary capture of attention by a specific information type can produce domain-specific activation. Participants indicated the presence of a flicker in rapidly alternating letter-string masks presented in the periphery. Despite letters not being relevant to the task, we fou...

journal_title：Neuroreport

authors： Finkbeiner M,Slotnick SD,Moo LR,Caramazza A

更新日期：2007-07-02 00:00:00

abstract：:Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior p...

journal_title：Neuroreport

authors： Wang YZ,Liu YY,Liu JP,You SW,Ju G

更新日期：2006-04-24 00:00:00

abstract：:Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma-band bursts (around 40...

journal_title：Neuroreport

authors： Grice SJ,Spratling MW,Karmiloff-Smith A,Halit H,Csibra G,de Haan M,Johnson MH

更新日期：2001-08-28 00:00:00

abstract：:Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...

journal_title：Neuroreport

authors： Han MH,Li Y,Yang XL

更新日期：1997-04-14 00:00:00

abstract：:Recently some authors have challenged the conventional association of directional motor neglect with damage of frontal structures, showing that pure sensory perceptual neglect (classically associated with parietal lesion) can follow damage of right frontal cortex. The aim of the present study was to assess the type of...

journal_title：Neuroreport

authors： Brighina F,Bisiach E,Piazza A,Oliveri M,La Bua V,Daniele O,Fierro B

更新日期：2002-12-20 00:00:00

abstract：:The interaction of vestibular inputs with different dynamic and spatial behavior, i.e., canal-otolith interaction, leads to spatio-temporal convergence. Vestibular neurons in the fastigial nucleus often exhibit spatio-temporal convergence. The present report demonstrates that the discharge rates of most vestibular neu...

journal_title：Neuroreport

authors： Wilden A,Glasauer S,Kleine JF,Büttner U

更新日期：2002-05-07 00:00:00

abstract：:Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lowe...

journal_title：Neuroreport

authors： Papa M,Sergeant JA,Sadile AG

更新日期：1997-05-06 00:00:00

abstract：:Somatotopic organization of the human medial wall of the cerebral hemispheres was studied using functional MRI conducted at high field strength (3 T) with fine spatial resolution ( approximately 2 mm). Healthy subjects performed paced, repetitive movements of the fingers and toes. Within the supplementary motor area (...

journal_title：Neuroreport

authors： Mayer AR,Zimbelman JL,Watanabe Y,Rao SM

更新日期：2001-12-04 00:00:00

abstract：:Dysfunction of the cholinergic system of the basal forebrain complex is one of the major contributors toward cognitive impairment in Alzheimer's disease (AD). In AD, degeneration of cholinergic fibers that project to the cerebral cortex and hippocampus may be attributed to the development of neurofibrillary tangles (N...

journal_title：Neuroreport

authors： Kim JM,Kim SS,Lee YD

更新日期：2015-09-09 00:00:00

abstract：:Bone marrow stromal cells are multipotent stem cells that have the potential to differentiate into bone, cartilage, fat and muscle. Recently, bone marrow stromal cells have been shown to have the capacity to differentiate into neurons under specific experimental conditions, using chemical factors. We now describe how ...

journal_title：Neuroreport

authors： Zurita M,Vaquero J,Oya S,Miguel M

更新日期：2005-04-04 00:00:00

abstract：:Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...

journal_title：Neuroreport

authors： Griffin SM,Pickard MR,Orme RP,Hawkins CP,Fricker RA

更新日期：2013-12-18 00:00:00

abstract：:We have evaluated the G1H line of transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly-93-->Ala) in tasks assessing different aspects of motor function to determine how early these deficits could be detected and their order of appearance. The earliest deficits were observed in tests of muscle strength a...

journal_title：Neuroreport

authors： Barnéoud P,Lolivier J,Sanger DJ,Scatton B,Moser P

更新日期：1997-09-08 00:00:00

abstract：:One problem in motor control concerns the mechanism whereby the central nervous system translates the motor cortical command encoded in cell activity into a coordinated contraction of limb muscles to generate a desired motor output. This problem is closely related to the design of adaptive systems that transform neuro...

journal_title：Neuroreport

authors： Lukashin AV,Amirikian BR,Georgopoulos AP

更新日期：1996-11-04 00:00:00