GABA uptake into isolated retinal Müller glial cells of the guinea-pig detected electrophysiologically.

Abstract:

:In order to investigate GABA uptake into Müller glial cells electrophysiologically, we used the whole-cell voltage-clamp technique. Since Müller cells were insensitive to application of muscimol and baclofen, the expression of GABAA and GABAB receptors can be excluded. Therefore, the observed GABA current must be due to an electrogenic GABA transporter. This transporter is driven by the transmembrane Na+ gradient, as replacement of the extracellular Na+ by choline inhibits the GABA current. Currents evoked by cis-4-aminocrotonic acid, a GABAC specific agonist, are also inhibited by replacement of extracellular Na+, indicating that this compound is a substrate for the uptake. The competitive GABA uptake blockers beta-alanine and nipecotic acid are substrates of the transporter as well, and produce 42% and 65% of the currents elicited by the same GABA concentration, respectively. Affinity of the transporter for GABA is high, the Km value being 5 microM at -80 mV.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Biedermann B,Eberhardt W,Reichelt W

doi

10.1097/00001756-199401120-00017

subject

Has Abstract

pub_date

1994-01-12 00:00:00

pages

438-40

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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