Disordered visual processing and oscillatory brain activity in autism and Williams syndrome.

Abstract:

:Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma-band bursts (around 40 Hz) when the brain is required to achieve such binding. Here we explore gamma-band EEG in autism and Williams Syndrome and demonstrate differential abnormalities in the two phenotypes. We show that despite putative processing similarities at the cognitive level, binding in Williams syndrome and autism can be dissociated at the neurophysiological level by different abnormalities in underlying brain oscillatory activity. Our study is the first to identify that binding-related gamma EEG can be disordered in humans.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Grice SJ,Spratling MW,Karmiloff-Smith A,Halit H,Csibra G,de Haan M,Johnson MH

doi

10.1097/00001756-200108280-00021

subject

Has Abstract

pub_date

2001-08-28 00:00:00

pages

2697-700

issue

12

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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