Abstract:
:The amounts of three adenylyl cyclase (AC) subtypes in membranes from brain obtained post-mortem from patients with dementia of Alzheimer type (DAT) and controls were studied by Western blotting using polyclonal antibodies. AC subtypes were characterized by preabsorption by complementary peptides, species difference, tissue distribution and by using AC-VI-transfected cells. Immunoreactivities of AC-I and AC-II subtypes, which are predominant in brain tissue were decreased 40.5% (p < 0.02) and 52.0% (p < 0.02), respectively in DAT compared with controls. No significant difference in immunoreactivity of AC-V/VI subtypes distributed in various other tissues was observed. Our results are the first to indicate that reduced levels of brain-specific AC subtypes occur in DAT.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yamamoto M,Ozawa H,Saito T,Frölich L,Riederer P,Takahata Ndoi
10.1097/00001756-199611250-00033subject
Has Abstractpub_date
1996-11-25 00:00:00pages
2965-70issue
18eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
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