Voltage-activated intracellular calcium transients in thalamic relay cells and interneurons.

abstract：:The event-related potential technique was used to investigate the time course and scalp-potential topography for the numerical distance effect in a number-matching task. Twenty undergraduates judged whether a number matched or did not match another number presented 1.5 s earlier. Compared with number pairs with a 'sma...

journal_title：Neuroreport

authors： Zhou X,Chen C,Dong Q,Zhang H,Chen C,Qiao S,Zhao H,Jiang T,Guo Y

更新日期：2006-07-17 00:00:00

abstract：:Hypoxic-ischemic brain damage (HIBD) occurs due to intrauterine hypoxia ischemia influencing the energy supply for fetal brain cells, which affects the metabolism of the brain to make the brain suffer a severe damage. Erythropoietin (EPO), which regulates hemacytopoiesis, is a kind of cytokine. EPO is sensitive to hyp...

journal_title：Neuroreport

authors： Huang R,Zhang J,Ren C,Zhang X,Gu L,Dong Y,Zhang J,Zhang J

更新日期：2019-03-06 00:00:00

abstract：:Spinally administered adenosine reduces hypersensitivity in animals and humans with nerve injury, but also causes transient pain in humans and reduces tonic inhibition in spinal neurons. Nerve injury results in increased tonic spinal cord adenosine A1 receptor activation, consistent with a role for adenosine to genera...

journal_title：Neuroreport

authors： Martin TJ,Eisenach JC,Misler J,Childers SR

更新日期：2006-10-23 00:00:00

abstract：:Epilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical...

journal_title：Neuroreport

authors： Lee JK,Jeong JW,Jang T,Lee GW,Han H,Kang JS,Kim IH

更新日期：2014-11-12 00:00:00

abstract：:The mechanism by which IL-1 beta exerts its actions in the brain during systemic inflammation is not fully understood, as neither IL-1 receptor gene expression nor IL-1 binding have been identified in significant levels in key areas that respond to IL-1 beta. Having hypothesized that perivascular nitric oxide (NO) mig...

journal_title：Neuroreport

authors： Wong ML,Bongiorno PB,al-Shekhlee A,Esposito A,Khatri P,Licinio J

更新日期：1996-11-04 00:00:00

abstract：:NCAM-180 knockout mice, which have documented deficits in neural migration, were used to determine whether developmental abnormalities could lead to morphological changes and alterations in sensory motor gating mechanisms. Measurement of the lateral ventricle showed that NCAM-180-/- mice had marked increases in both t...

journal_title：Neuroreport

authors： Wood GK,Tomasiewicz H,Rutishauser U,Magnuson T,Quirion R,Rochford J,Srivastava LK

更新日期：1998-02-16 00:00:00

abstract：:A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...

journal_title：Neuroreport

authors： King C,Bartlett C,Sauvé Y,Lund R,Dunlop S,Beazley L

更新日期：2006-02-06 00:00:00

abstract：:We investigated the effect of an NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), on the levels of endogenous GABA in the rat striatum using in vivo microdialysis. Rats were perfused with the artificial CSF containing L-NMMA (0.1, 0.3 and 1.0 mM) or its inactive isomer D-NMMA (1.0 mM) for 1 h. Infusion of L-N...

journal_title：Neuroreport

authors： Semba J,Sakai M,Miyoshi R,Kito S

更新日期：1995-07-10 00:00:00

abstract：:The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, ...

journal_title：Neuroreport

authors： Horschitz S,Hummerich R,Schloss P

更新日期：2001-07-20 00:00:00

abstract：:The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...

journal_title：Neuroreport

authors： Date S,Kurumadani H,Yoshimura M,Fukae A,Onishi K,Hayashi J,Shinomiya R,Sunagawa T

更新日期：2019-04-10 00:00:00

abstract：:By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative an...

journal_title：Neuroreport

authors： Sasaki M,Shibata E,Tohyama K,Kudo K,Endoh J,Otsuka K,Sakai A

更新日期：2008-11-19 00:00:00

abstract：:Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detect...

journal_title：Neuroreport

authors： El-Agnaf OM,Curran MD,Wallace A,Middleton D,Murgatroyd C,Curtis A,Perry R,Jaros E

更新日期：1998-12-01 00:00:00

abstract：:This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice ...

journal_title：Neuroreport

authors： Matsumoto M,Nakagawa T,Higashi T,Kim TS,Kojima K,Kita T,Sakamoto T,Ito J

更新日期：2005-05-31 00:00:00

abstract：:A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the pr...

journal_title：Neuroreport

authors： Clemen CS,Herr C,Lie AA,Noegel AA,Schröder R

更新日期：2001-05-08 00:00:00

abstract：:The amounts of three adenylyl cyclase (AC) subtypes in membranes from brain obtained post-mortem from patients with dementia of Alzheimer type (DAT) and controls were studied by Western blotting using polyclonal antibodies. AC subtypes were characterized by preabsorption by complementary peptides, species difference, ...

journal_title：Neuroreport

authors： Yamamoto M,Ozawa H,Saito T,Frölich L,Riederer P,Takahata N

更新日期：1996-11-25 00:00:00

abstract：:Short-term exposure of primary cultures of cerebellar granule cells from neonatal rat brain to high concentrations of glutamate results in neuronal degeneration. We found that glutamate, before causing neuronal degeneration, induced a significant increase of Tau protein immunostaining. Time-course experiments revealed...

journal_title：Neuroreport

authors： Pizzi M,Valerio A,Ribola M,Spano PF,Memo M

更新日期：1993-06-01 00:00:00

abstract：:Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...

journal_title：Neuroreport

authors： Ghauri M,Chapman AG,Meldrum BS

更新日期：1996-06-17 00:00:00

abstract：:Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...

journal_title：Neuroreport

authors： Matsuoka N,Aigner TG

更新日期：1996-01-31 00:00:00

abstract：:In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse model of Huntington's disease (HD). Using BrdU labelling for dividing cells at two different time points (5 and 20 weeks) in transgenic and wi...

journal_title：Neuroreport

authors： Lazic SE,Grote H,Armstrong RJ,Blakemore C,Hannan AJ,van Dellen A,Barker RA

更新日期：2004-04-09 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4+/-11.0...

journal_title：Neuroreport

authors： Rollnik JD,Huber TJ,Mogk H,Siggelkow S,Kropp S,Dengler R,Emrich HM,Schneider U

更新日期：2000-12-18 00:00:00

abstract：:Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...

journal_title：Neuroreport

authors： Hösli L,Hösli E,Winter T,Stauffer S

更新日期：1994-07-21 00:00:00

abstract：:GABAA receptors mediate the inhibition of somatostatin release in hypothalamic neurones. To study the possible effect of GABA on somatostatin biosynthesis, somatostatin and preprosomatostatin mRNA levels were evaluated after exposure of hypothalamic neurones to muscimol or bicuculline. Muscimol (50 microM) decreased p...

journal_title：Neuroreport

authors： Rage F,Jalaguier S,Rougeot C,Tapia-Arancibia L

更新日期：1993-03-01 00:00:00

abstract：:There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatori...

journal_title：Neuroreport

authors： Beckers GJ,Bolhuis JJ,Okanoya K,Berwick RC

更新日期：2012-02-15 00:00:00

abstract：:Neuronal activity may lead to long lasting changes in cell phenotype through induction of genes such as c-fos which encode transcriptional regulatory factors. Odor-activated olfactory bulb cells exhibit increases in c-fos mRNA expression. The present study examined whether odor stimulation of awake rats also leads to ...

journal_title：Neuroreport

authors： Guthrie KM,Gall CM

更新日期：1995-11-13 00:00:00

abstract：:Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and...

journal_title：Neuroreport

authors： Weydt P,Möller T

更新日期：2005-04-25 00:00:00

abstract：:In the adult brain, neural proliferation is almost absent and neurons are generally not renewed. By contrast, in the olfactory organ, olfactory neurons are produced continuously throughout life. To investigate whether specific cell cycle inhibitors are involved in the control of neural quiescence in adulthood, we comp...

journal_title：Neuroreport

authors： Legrier ME,Ducray A,Propper A,Kastner A

更新日期：2001-10-08 00:00:00

abstract：:Prior work has shown that kappa opioids may attenuate the effects of analgesic mu receptor agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia following exposure to a signal for shock is attenuated by infusions of the kappa agonist U69593 into the rostral ventromedial m...

journal_title：Neuroreport

authors： Foo H,Helmstetter FJ

更新日期：2000-10-20 00:00:00

abstract：:The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful fac...

journal_title：Neuroreport

authors： Killgore WD,Gruber SA,Yurgelun-Todd DA

更新日期：2008-10-08 00:00:00

abstract：:Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...

journal_title：Neuroreport

authors： Tsurugizawa T,Kondoh T,Torii K

更新日期：2008-07-16 00:00:00

abstract：:The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the depressant effect of flupirtine on the monosynaptic Hoffmann (H)-reflex recorded from plantar foot muscles and on polysynaptic flexor reflexes recorded from tibialis muscle. Intrathecal administr...

journal_title：Neuroreport

authors： Schwarz M,Block F,Pergande G

更新日期：1994-10-03 00:00:00