Abstract:
:Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds produced hyperpolarizations, suggesting a colocalization of functional cholinergic and SOM receptors on the glial membrane. Combined immunohistochemical and autoradiographic binding studies demonstrating that almost all astrocytes which were immunostained by the monoclonal muscarinic or nicotinic antibodies were also intensely labelled by 125I-SOM, provide further evidence for the coexistence of cholinergic and SOM receptors on astrocytes.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Hösli L,Hösli E,Winter T,Stauffer Sdoi
10.1097/00001756-199407000-00015subject
Has Abstractpub_date
1994-07-21 00:00:00pages
1469-72issue
12eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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