Drug interactions represented by high resolution computer graphics.

abstract：:A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...

journal_title：Neuroreport

authors： Bakalkin G,Yakovleva T,Hurd YL,Nussenzweig A,Li GC,Terenius L

更新日期：1998-06-22 00:00:00

abstract：:The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell de...

journal_title：Neuroreport

authors： Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF

更新日期：2004-07-19 00:00:00

abstract：:In a three-stimulus oddball task, the amplitude of P3a elicited by deviant stimuli increases with an increase in the difficulty of discriminating between standard and target stimuli (i.e. task-difficulty effect on P3a), indicating that attentional capture by deviant stimuli is enhanced with an increase in task difficu...

journal_title：Neuroreport

authors： Sugimoto F,Kimura M,Takeda Y,Katayama J

更新日期：2017-08-16 00:00:00

abstract：:We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a smal...

journal_title：Neuroreport

authors： Foutz AS,Pierrefiche O,Denavit-Saubié M

更新日期：1994-01-12 00:00:00

abstract：:Musical expertise has been shown to induce widespread structural and functional alterations in the brain, even-handedly affecting top-down and bottom-up factors. At the same time, it is known that the early evoked gamma-band response (GBR) can be modulated by top-down as well as bottom-up factors such as attention and...

journal_title：Neuroreport

authors： Ott CG,Stier C,Herrmann CS,Jäncke L

更新日期：2013-06-19 00:00:00

abstract：:Phosphorus magnetic resonance spectroscopy was used to determine effects of acute and chronic alcohol exposure on brain intracellular free magnesium concentration (Mgf) and bioenergetic state in rats. Acute alcohol (3 mg kg-1, i.p.) resulted in a transient ( < 2h) decline in brain Mgf and cytosolic phosphorylation rat...

journal_title：Neuroreport

authors： Mullins PG,Vink R

更新日期：1995-08-21 00:00:00

abstract：:Diabetic peripheral neuropathy is the most common complication of diabetes mellitus and leads to sensory symptoms, including diabetic neuropathic pain (DNP). DNP is a major public health problem because it has a considerable impact on life quality of diabetes mellitus patients. Therefore, development of novel effectiv...

journal_title：Neuroreport

authors： Li P,Xiong DL,Sun WP,Xu SY

更新日期：2018-12-05 00:00:00

abstract：:We examined covert and overt orienting in response to non-predictive gaze direction cues and investigated whether the subcortical superior colliculus (SC) plays a role in this type of orienting. Participants viewed a centrally presented gazing schematic face and responded to targets appearing at gazed-at or non-gazed-...

journal_title：Neuroreport

authors： Friesen CK,Kingstone A

更新日期：2003-03-03 00:00:00

abstract：:We inserted microelectrodes in eye movement-evoking cortices (EMECs) of cats and examined whether neurones in the EMECs received sensory input from guide signals and fired prior to saccades. The five EMECs were the medial wall of the hemisphere under the cruciate sulcus, the medical and lateral bank of the presylvian ...

journal_title：Neuroreport

authors： Tamai Y,Kimura A

更新日期：1996-10-02 00:00:00

abstract：:We recently reported behavioral improvements following intrastriatal transplantation of cryopreserved cultured human neuroteratocarcinoma-derived cells (hNT neurons) in rats with cerebral ischemia induced by occlusion of the middle cerebral artery. In the present study, the viability and survival of hNT neurons were e...

journal_title：Neuroreport

authors： Borlongan CV,Saporta S,Poulos SG,Othberg A,Sanberg PR

更新日期：1998-08-24 00:00:00

abstract：:Hypoxia-induced changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was ma...

journal_title：Neuroreport

authors： Staunton M,Dulitz MG,Fang C,Schmeling WT,Kampine JP,Farber NE

更新日期：1998-05-11 00:00:00

abstract：:The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

journal_title：Neuroreport

authors： Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

更新日期：2001-01-22 00:00:00

abstract：:In several central nervous system neuronal populations, axotomy triggers the upregulation of regeneration-associated genes such as c-Jun, which determines neurons ability to regenerate axon in a growth-permissive environment. We analyzed the expression of c-Jun in rat ventral medullary neurons after cervical hemisecti...

journal_title：Neuroreport

authors： Vinit S,Boulenguez P,Efthimiadi L,Stamegna JC,Gauthier P,Kastner A

更新日期：2005-09-28 00:00:00

abstract：:Intraplantar carrageenan induced a peripheral oedema and c-Fos like immunoreactivity (Fos-LI) in L4-L5 segments in the dorsal horn (DH) of the rat spinal cord. The total number of carrageenan evoked Fos-LI neurones was 153 +/- 10 per section, with a predominant localization in the superficial and deep laminae of the D...

journal_title：Neuroreport

authors： Buritova J,Honoré P,Chapman V,Besson JM

更新日期：1995-07-10 00:00:00

abstract：:The neuroprotective effect of docosahexaenoic acid (DHA) on the glutamate-induced cytotoxicity in rat hippocampal cultures was investigated in the present study. DHA at 5-50 microg/ml successfully protected neurons against the cytotoxicity, markedly increased the cell viability, inhibited both nitric oxide (NO) produc...

journal_title：Neuroreport

authors： Wang X,Zhao X,Mao ZY,Wang XM,Liu ZL

更新日期：2003-12-19 00:00:00

abstract：:All-night recordings of respiration, ballistocardiogram, and body movements were obtained using the static charge-sensitive bed (SCSB) and automatically analysed data were compared with sleep stages. The mean sum of eight SCSB variability parameters was lowest in slow wave sleep (SWS), higher during stage 2 (S2), and ...

journal_title：Neuroreport

authors： Kaartinen J,Erkinjutti M,Rauhala E

更新日期：1996-04-10 00:00:00

abstract：:Although valproate (VPA) is used widely in the treatment of bipolar mood disorder and epilepsy, the precise mechanism of action in the brain remains elusive. In this study, we investigated the effects of subchronic VPA administrations on the expression of the cyclin-dependent kinase inhibitor (Cdkn) family in the hipp...

journal_title：Neuroreport

authors： Aizawa S,Yamamuro Y

更新日期：2015-10-21 00:00:00

abstract：:Previous research has suggested that exposure to radiofrequency electromagnetic fields increases electroencephalogram spectral power in non-rapid eye movement sleep. Other sleep parameters have also been affected following exposure. We examined whether aspects of sleep architecture show sensitivity to electromagnetic ...

journal_title：Neuroreport

authors： Loughran SP,Wood AW,Barton JM,Croft RJ,Thompson B,Stough C

更新日期：2005-11-28 00:00:00

abstract：:Axons from central neurons can regenerate into the tissue matrix formed within a silicone tube capped with two pieces of peripheral nerve, one of which had been sutured to a lesion in the spinal cord. Such axons can grow through a transversely positioned microchip in the tube. These observations suggest that it is fea...

journal_title：Neuroreport

authors： Lundborg G,Drott J,Wallman L,Reimer M,Kanje M

更新日期：1998-03-30 00:00:00

abstract：:Neuroimaging evidence suggests that human Brodmann area 5 (BA5) within the superior parietal lobule contributes to movement planning. However, a causal role for the contribution of BA5 to preparatory processes has yet to be reported. We used paired-pulse transcranial magnetic stimulation to investigate the influence o...

journal_title：Neuroreport

authors： Mackenzie TN,Bailey AZ,Mi PY,Tsang P,Jones CB,Nelson AJ

更新日期：2016-09-28 00:00:00

abstract：:Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DN...

journal_title：Neuroreport

authors： Su JH,Satou T,Anderson AJ,Cotman CW

更新日期：1996-01-31 00:00:00

abstract：:Gastrin-releasing peptide plays an important role in regulating the advanced functions of the brain including emotional behavior, learning and memory. What's more, gastrin-releasing peptide levels are also associated with the central nervous system diseases. Our previous study proposed that intraperitoneal injection o...

journal_title：Neuroreport

authors： Yao Y,Yang X,Wang Z

更新日期：2019-10-16 00:00:00

abstract：:Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of br...

journal_title：Neuroreport

authors： Hot P,Sequeira H

更新日期：2013-11-13 00:00:00

abstract：:There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatori...

journal_title：Neuroreport

authors： Beckers GJ,Bolhuis JJ,Okanoya K,Berwick RC

更新日期：2012-02-15 00:00:00

abstract：:A simple but effective method has been devised to explore backward masking in cutaneous sensation. In this method a weak electrical shock to the palm (test stimulus) is followed by a stronger shock to the same site (masking stimulus). By combining this stimulation strategy with a choice reaction time paradigm, it has ...

journal_title：Neuroreport

authors： MacIntyre NJ,McComas AJ

更新日期：1996-06-17 00:00:00

abstract：:Neuronal interferon-gamma (N-IFN-gamma), recently isolated from the nervous system, has a molecular weight distinct from that of lymphocyte-derived IFN-gamma, but crossreacts immunologically and shares certain bioactivities with this cytokine. In the rat brain N-IFN-gamma-immunoreactive perikarya were concentrated in ...

journal_title：Neuroreport

authors： Bentivoglio M,Florenzano F,Peng ZC,Kristensson K

更新日期：1994-12-20 00:00:00

abstract：:GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium s...

journal_title：Neuroreport

authors： Rovira C,Ben-Ari Y

更新日期：1994-10-27 00:00:00

abstract：:Results from a computer model of a thalamic network predict that agents augmenting GABA(A)-mediated inhibition in the reticular thalamic (RE) nucleus will be antiepileptic or desynchronizing. This provides support for the hypothesis that antiepileptics like benzodiazepines may exert their effects through an isolated i...

journal_title：Neuroreport

authors： Thomas E,Lytton WW

更新日期：1998-03-09 00:00:00

abstract：:The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...

journal_title：Neuroreport

authors： Mikuni N,Nishiyama K,Babb TL,Ying Z,Najm I,Okamoto T,Lüders HO,Wylie C

更新日期：1999-05-14 00:00:00

abstract：:Previous studies using magnetoencephalographic (MEG) recordings have revealed neuronal populations responding to discrete auditory stimuli in the supratemporal cortex of the human brain. We used the novel whole-head magnetometer (Neuromag-122) to determine whether regions outside the auditory cortex are activated by a...

journal_title：Neuroreport

authors： Lavikainen J,Huotilainen M,Pekkonen E,Ilmoniemi RJ,Näätänen R

更新日期：1994-12-30 00:00:00