Abstract:
:Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DNA damage within neurons in the AD brain and increases in Bcl-2 immunoreactivity. In this study, we examined the relationship between Bcl-2 expression and nuclear DNA damage or tangle formation. Nuclei exhibiting DNA damage were associated with an up-regulation of Bcl-2 expression, whereas tangle-bearing neurons were associated with a down-regulation of Bcl-2 expression.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Su JH,Satou T,Anderson AJ,Cotman CWdoi
10.1097/00001756-199601310-00015subject
Has Abstractpub_date
1996-01-31 00:00:00pages
437-40issue
2eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
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