IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration.

Abstract:

:Interleukin-6 (IL-6) is a neurotrophic cytokine, however, its direct effect on nerve regeneration has not been well characterized. We therefore examined the effect of IL-6 on neurite regeneration using the rat dorsal root ganglion. IL-6 significantly enhanced neurite regeneration from transected nerve terminals. We also examined the mRNA expression of IL-6 family cytokines and their receptors during the regeneration. The mRNA expressions of IL-6, IL-6 receptor, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF) receptor alpha, and LIF receptor beta showed no significant differences by the addition of IL-6. In contrast, IL-6 enhanced the mRNA expression of gp130 and CNTF. In addition, CNTF significantly increased neurite regeneration when added exogenously. Our data suggest that IL-6 enhanced regeneration via up-regulating CNTF expression.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Shuto T,Horie H,Hikawa N,Sango K,Tokashiki A,Murata H,Yamamoto I,Ishikawa Y

doi

10.1097/00001756-200104170-00043

subject

Has Abstract

pub_date

2001-04-17 00:00:00

pages

1081-5

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

杂志文章
  • Loss feedback negativity elicited by single- versus conjoined-feature stimuli.

    abstract::Event-related brain potential studies show that negative feedback in guessing tasks elicits a medial frontal negativity. Most theory and experimentation concerning this feedback-related negativity (FRN) has assumed that the FRN has little relationship to the perceptual characteristics of the feedback. This study chall...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832a3250

    authors: Liu Y,Gehring WJ

    更新日期:2009-04-22 00:00:00

  • Evidence that matrix recognition contributes to stabilization but not induction of LTP.

    abstract::Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199108000-00013

    authors: Xiao P,Bahr BA,Staubli U,Vanderklish PW,Lynch G

    更新日期:1991-08-01 00:00:00

  • Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself.

    abstract::We earlier showed that leucine-rich glioma inactivated 3 (LGI3) colocalizes with amyloid beta peptide (Abeta) taken up by astrocytes both in vitro and in vivo, and that LGI3 accumulated with endocytosis-associated proteins in aged monkey brains. In this study, we confirmed that LGI3 localizes to the endocytic pathway ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32830a4cc4

    authors: Okabayashi S,Kimura N

    更新日期:2008-08-06 00:00:00

  • No relation between 2D : 4D fetal testosterone marker and dyslexia.

    abstract::It has been suggested that high levels of prenatal testosterone exposure are implied in the aetiology of dyslexia and its frequently co-occurring sensory problems. This study examined 2D : 4D digit ratio (a marker of fetal testosterone exposure) in dyslexic and normal reading children. No group differences in 2D : 4D ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282e9a754

    authors: Boets B,De Smedt B,Wouters J,Lemay K,Ghesquière P

    更新日期:2007-09-17 00:00:00

  • Tannic acid inhibits electrogenic Na+/HCO3- co-transporter activity in embryonic neural stem cell-derived radial glial-like cells.

    abstract::Self-renewing neural stem cells and progenitor cells are cell populations that generate radial glial cells and neurons through asymmetric division. Regulation of intracellular pH in stem cells with high metabolic activity is critical for both cell signaling and proliferation. We have recently found that a S0859-inhibi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001372

    authors: Nordström T,Zhenyu G,Andersson LC,Åkerman KEO

    更新日期:2020-01-08 00:00:00

  • Distribution of GABA(B(1a)), GABA(B(1b)) and GABA(B2) receptor protein in cerebral cortex and thalamus of adult rats.

    abstract::The distribution of GABA(B) receptor subunits GABA(B(1a)), GABA(B(1b)) and GABA(B2), has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABA(B(1a)) and GABA(B(1b)) subunits co-localized with GABA(B2) in the cortex, where afferent thalamic GABAergic axons project ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200103050-00032

    authors: Princivalle AP,Pangalos MN,Bowery NG,Spreafico R

    更新日期:2001-03-05 00:00:00

  • Effects of ensheathing cells transplanted into photochemically damaged spinal cord.

    abstract::Transplantation of olfactory ensheathing cells (OECs) into photochemically damaged rat spinal cord diminished astrocyte reactivity and parenchyma cavitation. The photochemical lesion performed at T12--L1 resulted in severe damage to the spinal cord, so that during the first 15 days postoperation all rats dragged their...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200108080-00005

    authors: Verdú E,García-Alías G,Forés J,Gudiño-Cabrera G,Muñetón VC,Nieto-Sampedro M,Navarro X

    更新日期:2001-08-08 00:00:00

  • T2-sequence with contrast inversion: diagnostic value in the investigation of gray matter heterotopias.

    abstract::To compare the diagnostic value of T1-inversion recovery sequence (T1 IR) to that of a T2-sequence with contrast inversion (T2 CI) in the investigation of heterotopias. In this study, we processed a contrast-inverted copy of our coronal T2-sequence of 21 patients with subependymal and subcortical heterotopias on an on...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001463

    authors: Rösch J,Mennecke A,Knott M,Hamer HM,Doerfler A,Engelhorn T

    更新日期:2020-06-07 00:00:00

  • Visually induced gamma-band responses to coherent and incoherent motion: a replication study.

    abstract::The present study was based on earlier findings that the observation of a coherently moving long bar induced gamma-band activity in humans. The power in the EEG-gamma-band was reduced during the presentation of two incoherently moving short bars. The present study demonstrates the replicability of this cortical activi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199707280-00031

    authors: Müller MM,Junghöfer M,Elbert T,Rochstroh B

    更新日期:1997-07-28 00:00:00

  • Increases in K+ conductance and Ca2+ influx under high glucose with suppressed Na+/K+-pump activity in rat myelinated nerve fibers.

    abstract::To test the combined effect of high glucose and decreased Na+/K+-pump activity, a condition which closely mimics the diabetic state, on nerve ionic currents, changes in action potential and membrane current induced by high glucose in the presence of ouabain were investigated using voltage clamp analysis in rat single ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200008030-00040

    authors: Takigawa T,Yasuda H,Terada M,Maeda K,Haneda M,Kashiwagi A,Kitasato H,Kikkawa R

    更新日期:2000-08-03 00:00:00

  • Non-conscious choice in cutaneous backward masking.

    abstract::A simple but effective method has been devised to explore backward masking in cutaneous sensation. In this method a weak electrical shock to the palm (test stimulus) is followed by a stronger shock to the same site (masking stimulus). By combining this stimulation strategy with a choice reaction time paradigm, it has ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199606170-00015

    authors: MacIntyre NJ,McComas AJ

    更新日期:1996-06-17 00:00:00

  • Opioid receptors in the human cerebellum: evidence from [11C]diprenorphine PET, mRNA expression and autoradiography.

    abstract::Little is known regarding opioid receptors in the human cerebellum. The present [11C]diprenorphine PET study investigated opioid receptor binding in the human cerebellum in vivo, and showed a differential binding level in cerebellar cortex, vermis and dentate nuclei. The additional study in vitro of opioid receptors i...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902250-00032

    authors: Schadrack J,Willoch F,Platzer S,Bartenstein P,Mahal B,Dworzak D,Wester HJ,Zieglgänsberger W,Tölle TR

    更新日期:1999-02-25 00:00:00

  • Comparison of visual--vestibular interaction in insulin-dependent and non-insulin-dependent diabetes mellitus.

    abstract::We compared various measures of visual-vestibular interaction in subjects with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM), as well as non-diabetic controls. Subjects with IDDM exhibited significantly greater postural sway than controls on those conditions in the Clini...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200002280-00012

    authors: Darlington CL,Erasmus J,Nicholson M,King J,Smith PF

    更新日期:2000-02-28 00:00:00

  • Motor execution and imagination networks in post-stroke dystonia.

    abstract::Reorganization of motor execution and imagination networks was studied in six patients with unilateral dystonia secondary to a subcortical stroke and compared with seven control subjects using fMRI. Patients performed imagined and real auditory-cued hand movements. Movements of the dystonic hand resulted in overactivi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200408260-00010

    authors: Lehéricy S,Gerardin E,Poline JB,Meunier S,Van de Moortele PF,Le Bihan D,Vidailhet M

    更新日期:2004-08-26 00:00:00

  • Automatic detection of lexical change: an auditory event-related potential study.

    abstract::We investigated the detection of rare task-irrelevant changes in the lexical status of speech stimuli. Participants performed a nonlinguistic task on word and pseudoword stimuli that occurred, in separate conditions, rarely or frequently. Task performance for pseudowords was deteriorated relative to words, suggesting ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f0ea16

    authors: Muller-Gass A,Roye A,Kirmse U,Saupe K,Jacobsen T,Schröger E

    更新日期:2007-10-29 00:00:00

  • Coexistence of cholinergic and somatostatin receptors on astrocytes of rat CNS.

    abstract::Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199407000-00015

    authors: Hösli L,Hösli E,Winter T,Stauffer S

    更新日期:1994-07-21 00:00:00

  • Late developmental deficits in force control in children with hemiplegia.

    abstract::Differences related to development were investigated using a finger isometric force task in children with cerebral palsy and control children. The increase in force and force control observed in controls did not take place in patients. In the younger subset of patients (< 10 years) the force produced by the non-affect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200408260-00020

    authors: Smits-Engelsman BC,Rameckers EA,Duysens J

    更新日期:2004-08-26 00:00:00

  • Ipsilesional line bisection bias in patients with chronic parietal lesions.

    abstract::The current study investigated whether an ipsilesional bias in line bisection, a conventional measure for diagnosing hemispatial neglect, persists even in the absence of this syndrome in patients with chronic lesions restricted to posterior association cortex or dorsolateral prefrontal cortex. Both left and right hemi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199910190-00004

    authors: Machado L,Rafal RD

    更新日期:1999-10-19 00:00:00

  • Activation of kappa opioid receptors in the rostral ventromedial medulla blocks stress-induced antinociception.

    abstract::Prior work has shown that kappa opioids may attenuate the effects of analgesic mu receptor agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia following exposure to a signal for shock is attenuated by infusions of the kappa agonist U69593 into the rostral ventromedial m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200010200-00017

    authors: Foo H,Helmstetter FJ

    更新日期:2000-10-20 00:00:00

  • Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells.

    abstract::Amyloid precursor protein binding protein-1 (APP-BP1) was first identified as an interacting protein of APP. In this study, we explored whether APP-BP1 plays a role in neuronal differentiation of fetal neural stem cells. APP-BP1 knockdown by small interfering RNA treatment was found to downregulate neuronal differenti...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32834e7d4f

    authors: Hong BH,Ha S,Joo Y,Kim JA,Chang KA,Woo RS,Suh YH,Kim JH,Kim HS

    更新日期:2012-01-25 00:00:00

  • The beta-amyloid epitope masking activity in human brain is identified as albumin.

    abstract::Human brain homogenate proteins were analyzed for binding and processing activity in relation to brain beta-amyloid precursor protein (APP). The homogenate was purified by arginine-Sepharose 4B affinity chromatography, which traps proteins with affinity to certain groups of arginine residue, such as serine proteases a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199710200-00021

    authors: Matsumoto A,Minami M,Matsumoto R

    更新日期:1997-10-20 00:00:00

  • Left-hemisphere processing of emotional connotation during word generation.

    abstract::Areas of the brain's left hemisphere involved in retrieving words with emotional connotations were studied with fMRI. Participants silently generated words from different semantic categories which evoked either words with emotional connotations or emotionally neutral words. Participants repeated emotionally neutral wo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908200-00003

    authors: Crosson B,Radonovich K,Sadek JR,Gökçay D,Bauer RM,Fischler IS,Cato MA,Maron L,Auerbach EJ,Browd SR,Briggs RW

    更新日期:1999-08-20 00:00:00

  • Distribution and electrophysiological effects of motilin in Purkinje cells.

    abstract::Evidence exists that motilin immunoreactivity is highly expressed in Purkinje cells. In this study, immunohistochemistry and whole-cell patch-clamp recording were performed to investigate the spatial distribution and electrophysiological effects of motilin receptors in the cerebellum. We show here that motilin recepto...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328273bc98

    authors: Chen H,Chen L,Wang JJ,Wei HJ,Yung WH

    更新日期:2007-08-27 00:00:00

  • The expression and distribution of neural salient serine/arginine-rich protein 1 in rat retina.

    abstract::Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f0b542

    authors: Peng ZY,Lee SC,Chen XH

    更新日期:2007-10-29 00:00:00

  • Over-expression of MBP and PLP messenger RNA in 8-day-old trembler brain.

    abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP-22) gene which results in abnormal myelination of the peripheral nervous system. However, the clinical symptoms observed in the mutant suggest abnormalities in the central nervous system. Using the Northern blot te...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199406020-00015

    authors: Bascles L,Bonnet J,Garbay B

    更新日期:1994-06-02 00:00:00

  • Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retina.

    abstract::GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328010b898

    authors: Macnab LT,Williams SM,Pow DV

    更新日期:2006-12-18 00:00:00

  • Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus.

    abstract::Three SNARE proteins, SNAP-25, syntaxin 1A, and VAMP2 or synaptobrevin 2, constitute the minimal functional machinery needed for the regulated secretion of neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are associated with the induction of long-term plasticity at central synapses. In-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001258

    authors: Irfan M,Zurawski Z,Hamm HE,Bark C,Stanton PK

    更新日期:2019-07-03 00:00:00

  • Effects of adrenalectomy on hyperphagia induced by the 5-HT1A receptor agonist 8-OH-DPAT and 2-deoxy-D-glucose in rats.

    abstract::Effects of adrenalectomy on the 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)- and 2-deoxy-D-glucose (2-DG)-induced hyperphagia were investigated in rats. Prior adrenalectomy completely inhibited 2-DG-induced hyperphagia, although it did not affect increases in food intake elicited by 8-OH...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199806010-00030

    authors: Yamada J,Sugimoto Y,Yoshikawa T

    更新日期:1998-06-01 00:00:00

  • Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue.

    abstract::The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199209000-00007

    authors: Chen Y,Getchell ML,Ding X,Getchell TV

    更新日期:1992-09-01 00:00:00

  • A magnetoencephalographic study of Japanese vowel processing.

    abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000230503.47973.b7

    authors: Ogata E,Yumoto M,Itoh K,Sekimoto S,Karino S,Kaga K

    更新日期:2006-07-31 00:00:00