Abstract:
:Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, they did produce a reversible, dose dependent decay of LTP over a period of 40 min. This effect was not obtained with various non-RGD control peptides. These results suggest that stabilization of LTP requires adhesive interactions via specific matrix recognition sites, whereas induction and expression do not.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Xiao P,Bahr BA,Staubli U,Vanderklish PW,Lynch Gdoi
10.1097/00001756-199108000-00013subject
Has Abstractpub_date
1991-08-01 00:00:00pages
461-4issue
8eissn
0959-4965issn
1473-558Xjournal_volume
2pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The effect of chronic treatment with vitamin E (VE) on acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, as assessed by striatal dopamine (DA) depletion, was studied. Male C57B1/6J mice were fed VE (48 mg kg-1 per day, intragastric) for 4, 8, or 12 weeks prior to administration of MPTP (...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199109000-00012
更新日期:1991-09-01 00:00:00
abstract::Huntingtin, the protein product of the Huntington's disease gene, associates with vesicle membranes and microtubules in neurons. Analysis of axonal transport with a stop-flow, double crush ligation approach in rat sciatic nerve showed that full length huntingtin (350 kDa) and an N-terminal cleavage product (50 kD) wer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707070-00031
更新日期:1997-07-07 00:00:00
abstract::The human kallikrein gene family consists of 15 serine proteases. We examined the expression of the kallikrein genes in human cerebral cortex and hippocampus by RT-PCR and compared their expression between Alzheimer's disease (AD) and control tissue. KLK1, 4, 5, 6, 7, 8, 10, 11, 13 and 14 are expressed in both cerebra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108280-00031
更新日期:2001-08-28 00:00:00
abstract::In order to clarify whether neurophysiological profiles affect the performance of brain machine interfaces (BMI), we examined the relationships between amplitudes of movement-related cortical fields (MRCFs) and decoding performances during movement. Neuromagnetic activities were recorded in nine healthy participants d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834d935a
更新日期:2012-01-04 00:00:00
abstract::Involuntary eye movements to foveal stimulation were measured in a monkey while it performed a fixation task. Second-order plaid motion generated higher velocities of eye movements than did first-order gratings, yet the latency of the early following response was no different for grating or plaid motion. Nevertheless,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00032
更新日期:1999-02-05 00:00:00
abstract::TA20 cDNA was previously cloned as a neurite outgrowth factor from a hybridoma of mouse and rat cells, NG108-15. To clarify the detailed function and tissue distribution of this gene, homologous sequences of rat and mouse were identified. The cloned sequences had no homology with known genes, and was designated as spr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199907130-00018
更新日期:1999-07-13 00:00:00
abstract::Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson' disease motor imagery is impaired and that execution of overt movements is...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000132429.68206.48
更新日期:2004-06-28 00:00:00
abstract::Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXS...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00021
更新日期:2002-12-03 00:00:00
abstract::The distribution of the enzyme NADPH diaphorase in the region of the periaqueductal gray (PAG) was studied in the rat, rabbit, cat, monkey and human. In each species, the enzyme labelled a small band of neurones located below the level of the aqueduct and directly above the supraoculomotor gray in the middle of the an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-11-21 00:00:00
abstract::Hyperbaric oxygen (HBO) therapy and neural stem cell (NSC) transplantation can improve traumatic brain injury (TBI) clinically. This study aimed to investigate the mechanism of HBO promoting NSC proliferation and neurological recovery after TBI. Twenty-four Sprague-Dawley rats were divided randomly into three groups: ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000901
更新日期:2017-12-13 00:00:00
abstract::Previous event-related potential studies in Indo-European languages reported a surprising finding that failed syntactic category processing appears to block lexical-semantic integration, suggesting a functional primacy of syntax over semantics. An event-related potential experiment was conducted to test whether there ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282fda21d
更新日期:2008-05-07 00:00:00
abstract::Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199607080-00010
更新日期:1996-07-08 00:00:00
abstract::To investigate the implications of duration of deafness in the rehabilitation of unilateral deafness utilizing cochlear implantation. From the ongoing prospective cochlear implantation in unilateral deafness study, we looked at five adults who received a cochlear implant for long-term unilateral deafness. Speech perce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283642a93
更新日期:2013-09-11 00:00:00
abstract::We constructed two replication-deficient recombinant adenovirus vectors coding human basic fibroblast growth factor (bFGF), one with and one without the interleukin-2 (IL-2) secretory signal sequence and examined their neurotrophic effects on primary neuronal cells in vitro. The primary neuronal cells were successfull...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006260-00039
更新日期:2000-06-26 00:00:00
abstract::Hydroxyindole-O-methyltransferase (HIOMT), is the last enzyme of the melatonin biosynthesis pathway. We have applied immunocytochemistry and in situ hybridization to localize HIOMT producing cells, in the chicken epithalamus including the pineal gland. The selectivity of the hybridization signal over melatoninergic ce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00052
更新日期:1993-06-01 00:00:00
abstract::It is well known that dendritic cells play a key role in producing antigen-specific responses. Inversely, tolerogenic dendritic cells (TolDCs), a specialized subset, induce immune tolerance and negatively regulate autoimmune responses. Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the m...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000962
更新日期:2018-03-07 00:00:00
abstract::Intrinsic circuitry in the barrel cortex has been shown to be readily modifiable in response to changes in the patterns of sensory input, even in adult animals. It is believed that sensory experience modifies synaptic circuits by imposing specific patterns of repetitive presynaptic and postsynaptic coactivity, i.e. by...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511270-00007
更新日期:1995-11-27 00:00:00
abstract::Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of ment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000132202.69212.79
更新日期:2004-06-28 00:00:00
abstract::When two cylinders are passively moved in-phase on the volar surface of the right second and third fingers, human subjects estimate the stimuli to originate from one object, whereas two separate objects are estimated for out-of-phase stimuli. While five blindfolded subjects performed this estimation task, brain activi...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200304150-00012
更新日期:2003-04-15 00:00:00
abstract::Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) recepto...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000201504.23255.bc
更新日期:2006-02-27 00:00:00
abstract::GPR39, an orphan G protein-coupled receptor, has been recently identified as the receptor for the bioactive peptide obestatin. Obestatin is secreted from the stomach and acts as an anti-appetite hormone. This activity is induced whether obestatin is administered intraperitoneally or intracerebroventricularly. GPR39 is...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000215779.76602.93
更新日期:2006-05-29 00:00:00
abstract::To achieve neuronal differentiation of mouse bone mesenchymal stem cells (bMSCs) into neuron-like cells and explore the role of miR-122-5p that may regulate T-box brain 1 (Tbr1) expression during the induction. BMSCs were cultured and induced with butylated hydroxyanisole, retinoic acid (RA), basic fibroblast growth f...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000752
更新日期:2017-05-03 00:00:00
abstract::Our previous studies have shown that Panax notoginseng saponins (PNS) play a protective role in learning dysfunction of Alzheimer's disease, inhibit the deposition of Aβ1-40 and Aβ1-42, and reduce the content of App in the brain of SAMP8. In this study, we aimed to investigate the effects of PNS on α, β, and γ secreta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000048
更新日期:2014-01-22 00:00:00
abstract::Human somatosensory evoked potentials (SEP) contain high-frequency (600 Hz) wavelet bursts possibly reflecting repetitive population spikes in thalamocortical axons and/or postsynaptic responses. To dissociate thalamic and cortical burst components the recovery of intrathalamic SEP (derived from electrodes implanted f...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200004270-00030
更新日期:2000-04-27 00:00:00
abstract::Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199310000-00012
更新日期:1993-10-25 00:00:00
abstract:OBJECTIVE:The traditional Chinese medicine, Dendrobium nobile Lindl. polysaccharides (DNLP), reportedly has neuroprotective effects. However, its effects following ischemic stroke remain unclear. This study aimed to explore the role and mechanism of DNLP in experimental models of inflammation and apoptosis. METHODS:In...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001562
更新日期:2020-12-14 00:00:00
abstract::The mixed-action κ-opioid receptor (KOR) agonist, pentazocine, binds to both KOR and the µ-opioid receptor (MOR). Racemic (±)-pentazocine and (-)-pentazocine, each administered systemically, have been shown to produce antinociception in various animal models. In contrast, racemic (±)-pentazocine failed to produce anti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001043
更新日期:2018-07-04 00:00:00
abstract::Older adults are known to gain more than younger adults from the simultaneous presentation of semantically congruent sensory stimuli. Although these findings are quite exciting, they may not solely be due to age-related differences in multisensory processing. Rather, enhanced integration may be explained by alteration...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3281e72ae7
更新日期:2007-07-02 00:00:00
abstract::Motor imagery paradigms can be used to investigate motor preparation. We used positron emission tomography to compare regional cerebral blood flow (rCBF) in patients with Parkinson's disease and normal controls under three conditions: rest, motor imagery and motor execution. In controls, imagery activated bilateral do...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00040
更新日期:2001-03-26 00:00:00
abstract::This study used functional magnetic resonance imaging to characterize hemodynamic activation patterns recruited when the participants viewed mixed social communicative messages during a common interpersonal exchange. Mixed messages were defined as conflicting sequences of biological motion and facial affect signals th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283455c23
更新日期:2011-06-22 00:00:00