Abstract:
:Motor imagery paradigms can be used to investigate motor preparation. We used positron emission tomography to compare regional cerebral blood flow (rCBF) in patients with Parkinson's disease and normal controls under three conditions: rest, motor imagery and motor execution. In controls, imagery activated bilateral dorsolateral and mesial frontal cortex, inferior parietal cortex and precuneus. Motor execution additionally activated primary motor cortex (p < 0.001). Between-group, for imagery there was relative reduction in dorsolateral and mesial frontal activation in the patient group (p<0.01). For execution, there was impaired activation of right dorsolateral frontal cortex and basal ganglia (p<0.01). Our results support the notion that underfunctioning of mesial frontal and dorsolateral prefrontal cortex may underlie motor preparation in Parkinson's disease but also suggest that akinesia may occur in the absence of impaired mesial frontal cortex activation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Samuel M,Ceballos-Baumann AO,Boecker H,Brooks DJdoi
10.1097/00001756-200103260-00040subject
Has Abstractpub_date
2001-03-26 00:00:00pages
821-8issue
4eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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