Abstract:
:Immunohistochemistry was used to demonstrate urotensin I (UI), urotensin II (UII), and angiotensinogen (Ao)-like immunoreactivities (ir) in the CNS of Aplysia californica. The fish UI is a 41 amino acid peptide that has 50% identity with mammalian corticotropin-releasing factor (CRF). Identity also exists between UI and angiotensinogen in a tetrapeptide at the N-terminus. Ao-ir neurones were found in the F cluster of the Aplysia cerebral ganglia. Beaded Ao-ir fibres were seen in the neuropile and commissure of the cerebral, pleural and pedal ganglia. Ao neurosecretory material was also seen in the perineural region of the proximal supralabial nerve. Previously we have demonstrated UI and UII immunoreactivities were present in the CNS of Aplysia. A comparison of adjacent sections of the cerebral ganglia immunostained sequentially for UI, UII and Ao revealed that all three immunoreactivities co-existed in the same cells of the F cluster of the cerebral ganglia. Liquid-phase immunoabsorption of the Ao antiserum revealed that porcine or human angiotensinogen but not UI or UII were able to quench Ao immunostaining. Conversely UI and UII staining were quenched by white sucker (Catatomus commersoni) UI and goby (Gillichtys mirabilis) UII, respectively, but they were not modified by angiotensinogen. These results suggest that UI-, UII-, and Ao-like peptides might co-exist as separate entities in the cerebral ganglia of Aplysia californica where they can act in an integrated and/or independent modulatory way.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gonzalez GC,Roger I,Gonzalez E,Martinez-Padron M,Moore GJ,Lukowiak Kdoi
10.1097/00001756-199502000-00033subject
Has Abstractpub_date
1995-02-15 00:00:00pages
541-4issue
3eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives glutamatergic inputs from the prefrontal cortex and several subcortical regions. The glutamate...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000708
更新日期:2017-01-01 00:00:00
abstract::Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of ment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000132202.69212.79
更新日期:2004-06-28 00:00:00
abstract::Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays critical roles in neurotransmission, synaptic plasticity, learning and memory. The aim of this study was to examine, by in situ hybridization, prefrontal cortical expression of CaMKII alpha mRNA in postmortem brains of unipolar, bipolar, schizophrenic, and con...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203250-00029
更新日期:2002-03-25 00:00:00
abstract::EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001047
更新日期:2018-08-01 00:00:00
abstract::In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236862.08834.50
更新日期:2006-11-06 00:00:00
abstract::GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing r...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832f5130
更新日期:2009-08-26 00:00:00
abstract::The diversion of attention from a primary goal by irrelevant events is known as attention capture, and is often followed by a directed action. The hypothesis that corticospinal excitability is modulated by attention capture was tested using transcranial magnetic stimulation. Participants watched a video while sounds w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834bc6aa
更新日期:2011-11-16 00:00:00
abstract::Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199704140-00003
更新日期:1997-04-14 00:00:00
abstract::It has been reported that neurons in the amygdala respond to visual cues that predict reward and aversive outcomes. However, it remains unclear whether the representation of reinforcement in the amygdala depends on the relative preference for an outcome compared with another simultaneously available outcome. In this s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283294a2f
更新日期:2009-04-22 00:00:00
abstract::The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00021
更新日期:2001-04-17 00:00:00
abstract::Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the picc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283411685
更新日期:2010-12-29 00:00:00
abstract::Whole-cell recordings in voltage-clamp mode were performed on acutely isolated neurones from rat neocortex and neostriatum to examine the effects of the anticonvulsant phenytoin on a non-inactivating (persistent) Na+ current (INaP). INaP was chosen because it enhances neuronal excitability near firing threshold, which...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199509000-00017
更新日期:1995-09-11 00:00:00
abstract::Animal studies have shown brain ischaemia to cause oxidative damage to DNA and activation of caspase-3, leading to apoptosis. These changes may be exacerbated by reperfusion. To assess caspase-3 activation after transient and permanent brain ischaemia in man, we examined brain tissue from patients who had experienced ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008030-00030
更新日期:2000-08-03 00:00:00
abstract::Physical exercise has many health benefits, including improved cardiovascular fitness, lean muscle development, increased metabolism, and weight loss, as well as positive effects on brain functioning and cognition. Recent evidence suggests that regular physical exercise may also affect the responsiveness of reward reg...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000029
更新日期:2013-12-04 00:00:00
abstract::Hypoxia or global ischemia causes rapid loss of consciousness and a sudden increase in spontaneous transmitter release suggesting that coordinated synaptic activity is impaired. Gamma oscillations (30-100 Hz) are thought to provide for binding of parallel processed information in the brain, contributing to cognition a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f13e4f
更新日期:2007-11-19 00:00:00
abstract::Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) inhibitors on METH-induced hyperthermia and striatal dopaminergic neurotoxicity. Administration of METH (5 mg/kg; q. 3 h x 3) to Swiss Webster mice prod...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009110-00022
更新日期:2000-09-11 00:00:00
abstract::We investigated whether cerebellar transcranial magnetic stimulation (C-TMS) facilitates the excitability of the ipsilateral soleus motoneuron pool in resting humans, and whether the facilitation is modulated by a task that promotes cerebellar activity. A test tibial nerve stimulus evoking the H-reflex from the right ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000275
更新日期:2014-12-03 00:00:00
abstract::GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199410270-00034
更新日期:1994-10-27 00:00:00
abstract::The role of the right hemisphere in recovery of language function after left hemisphere stroke remains unclear. This prospective study aimed to determine the relationship between bilateral hemispheric changes and severity of aphasia in patients with chronic left hemisphere stroke. Twenty-three patients with left hemis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000929
更新日期:2018-01-03 00:00:00
abstract::Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200302100-00009
更新日期:2003-02-10 00:00:00
abstract::Antisera were produced against synthetic peptides predicted from the recent cloning of a delta opioid receptor, DOR-1. Confocal microscopic examination of immunostained spinal cord sections revealed that DOR-1 immunoreactive (-ir) nerve fibers and terminals form a moderately dense plexus within the superficial dorsal ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199312000-00041
更新日期:1993-12-13 00:00:00
abstract::In this study, we ask whether or not the involuntary capture of attention by a specific information type can produce domain-specific activation. Participants indicated the presence of a flicker in rapidly alternating letter-string masks presented in the periphery. Despite letters not being relevant to the task, we fou...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3281668bcc
更新日期:2007-07-02 00:00:00
abstract::Recently, we have generated transgenic mice (designated as SJLB) carrying human N279K mutant tau, one of the tau mutations causing parkinsonism linked to chromosome 17 (FTDP-17). SJLB mice mimic some features of behavioral alterations and neuronal pathology of patients with Alzheimer's disease. To investigate how tau ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328333b0e0
更新日期:2009-12-09 00:00:00
abstract::Pharmacologically distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199304000-00018
更新日期:1993-04-01 00:00:00
abstract::Lithium treatment lengthens the period of circadian rhythms in most organisms. In the present study, we tested whether lithium acts directly on the mammalian suprachiasmatic nucleus (SCN) to lengthen rhythms of individual neurons. Lithium increased the circadian period of firing rate rhythms of cultured SCN neurons in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009280-00042
更新日期:2000-09-28 00:00:00
abstract::The evaluative processing of the valence of action feedback is reflected by an event-related brain potential component called feedback-related negativity (FRN) or reward positivity (RewP). Recent studies have shown that FRN/RewP is markedly reduced when the action-feedback interval is long (e.g. 6000 ms), indicating t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000657
更新日期:2016-09-28 00:00:00
abstract::We can report, that by the use of indirect immunofluorescence techniques, that rat spinal motoneurons contain galanin-like immunoreactivity (LI). Furthermore, that galanin and calcitonin gene-related peptide (CGRP)-LI coexist in a number of spinal motoneurons. Co-localization could be demonstrated as thoracic, lumbar ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00003
更新日期:1992-04-01 00:00:00
abstract::Functional brain imaging techniques hold many promises as the methods of choice for identifying areas involved in the execution of language functions. The success of any of these techniques in fulfilling this goal depends upon their ability to produce maps of activated areas that overlap with those obtained through st...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199901180-00026
更新日期:1999-01-18 00:00:00
abstract::The mechanisms underlying the prolonged antidepressant effects after a single infusion of ketamine are only partially understood. Ketamine's half-life of ∼2 h cannot explain antidepressant effects that last for 1 week, suggesting the triggering of long-lasting neuroplasticity. Recent human pharmacokinetics (PK) data i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001131
更新日期:2018-11-07 00:00:00
abstract::Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely movin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000727
更新日期:2017-02-08 00:00:00