Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons.

Abstract:

:Lithium treatment lengthens the period of circadian rhythms in most organisms. In the present study, we tested whether lithium acts directly on the mammalian suprachiasmatic nucleus (SCN) to lengthen rhythms of individual neurons. Lithium increased the circadian period of firing rate rhythms of cultured SCN neurons in a concentration-dependent manner. Lithium had no effect on the amplitude of these rhythms, but did affect the period of some cells more than others. The results indicate that lithium acts directly on the SCN to lengthen the free-running period of individual neurons.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Abe M,Herzog ED,Block GD

doi

10.1097/00001756-200009280-00042

subject

Has Abstract

pub_date

2000-09-28 00:00:00

pages

3261-4

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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