Abstract:
:Lithium treatment lengthens the period of circadian rhythms in most organisms. In the present study, we tested whether lithium acts directly on the mammalian suprachiasmatic nucleus (SCN) to lengthen rhythms of individual neurons. Lithium increased the circadian period of firing rate rhythms of cultured SCN neurons in a concentration-dependent manner. Lithium had no effect on the amplitude of these rhythms, but did affect the period of some cells more than others. The results indicate that lithium acts directly on the SCN to lengthen the free-running period of individual neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Abe M,Herzog ED,Block GDdoi
10.1097/00001756-200009280-00042subject
Has Abstractpub_date
2000-09-28 00:00:00pages
3261-4issue
14eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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