Overexpression of piccolo C2A domain induces depression-like behavior in mice.

abstract：:MicroRNAs (miRNAs) play important roles in drug tolerance and regulating pain. The purpose of the present study is to explore the regulatory mechanism of miR-124-3p on dezocine tolerance against pain in a rat model. The expression of miR-124-3p and TRAF6 in spinal cord of rats was detected by quantitative reverse-tran...

journal_title：Neuroreport

authors： Huo Y,Zhang K,Zhang T,Han Y,Hu Z

更新日期：2021-01-06 00:00:00

abstract：:In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...

journal_title：Neuroreport

authors： Frechilla D,García-Osta A,Palacios S,Cenarruzabeitia E,Del Rio J

更新日期：2001-04-17 00:00:00

abstract：:Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson' disease motor imagery is impaired and that execution of overt movements is...

journal_title：Neuroreport

authors： Frak V,Cohen H,Pourcher E

更新日期：2004-06-28 00:00:00

abstract：:We investigated temporal relationships among EEG theta frequency, eye movement (EM) burst and phasic surge of arterial pressure (AP) during rapid eye movement (REM) sleep in six rats. Changes in EEG theta frequency, EM number, mean AP (MAP) and heart rate (HR) during 1 s bins were obtained with reference to the onset ...

journal_title：Neuroreport

authors： Sei H,Morita Y

更新日期：1996-11-25 00:00:00

abstract：:To examine the relationship between plasma lipoproteins and apolipoproteins in men with convictions for violent offences, blood was obtained from 15 men with a history of violence who were serving prison sentences for violent offences, and 25 age-matched male controls from the staff of the Argyll and Bute Psychiatric ...

journal_title：Neuroreport

authors： Gray RF,Corrigan FM,Strathdee A,Skinner ER,van Rhijn AG,Horrobin DF

更新日期：1993-06-01 00:00:00

abstract：:Voltage-dependent outward currents were examined in CA1 neurones by whole-cell recording in slices. Nine cells were recorded with the 'standard' internal solution (KMeSO4, HEPES, EGTA, CaCl2, and MgCl2) and held a potential (-54 +/- 3 mV) at which there was no significant outward current. Cromakalim (CROM, 100 microM)...

journal_title：Neuroreport

authors： Erdemli G,Krnjević K

更新日期：1994-06-27 00:00:00

abstract：:The expression of long-term potentiation and learning of a classical conditioning task increase [3H]-AMPA binding in hippocampus. Phospholipase A2 (PLA2) has been proposed to underly these changes, as PLA2 treatment of membrane preparations increases the affinity of AMPA receptors for agonists. We demonstrate here tha...

journal_title：Neuroreport

authors： Tocco G,Massicotte G,Standley S,Thompson RF,Baudry M

更新日期：1992-06-01 00:00:00

abstract：:Optic nerves of adult rats were crushed 2 mm behind the eye to examine the ability of retinal ganglion cells (RGCs) to regenerate their axons. Some animals were treated with the immunophilin ligands FK 506 or GPI 1046 for up to 4 weeks. After 10 days to 16 months, regenerating RGC axons were visualized using anterogra...

journal_title：Neuroreport

authors： Campbell G,Holt JK,Shotton HR,Anderson PN,Bavetta S,Lieberman AR

更新日期：1999-12-16 00:00:00

abstract：:The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distribute...

journal_title：Neuroreport

authors： Nickell WT,Norman AB,Wyatt LM,Shipley MT

更新日期：1991-01-01 00:00:00

abstract：:Little is known regarding opioid receptors in the human cerebellum. The present [11C]diprenorphine PET study investigated opioid receptor binding in the human cerebellum in vivo, and showed a differential binding level in cerebellar cortex, vermis and dentate nuclei. The additional study in vitro of opioid receptors i...

journal_title：Neuroreport

authors： Schadrack J,Willoch F,Platzer S,Bartenstein P,Mahal B,Dworzak D,Wester HJ,Zieglgänsberger W,Tölle TR

更新日期：1999-02-25 00:00:00

abstract：:Short-latency ocular following responses in monkeys, induced by first- and second-order motion during a fixation task, were sensitive to stimulus size, retinal eccentricity and motion duration. Latency of eye movements was no different for first- or second-order motion and simply marked the occurrence of movement in t...

journal_title：Neuroreport

authors： Benson PJ,Guo K

更新日期：1998-12-01 00:00:00

abstract：:An exaggerated startle response caused by mutations of the alpha 1 subunit gene of the inhibitory glycine receptor (GLRA1) is the key symptom of human hyperekplexia or startle disease. The recessive mouse mutant spasmodic (spd) carries a missense mutation in the corresponding murine Glra1 gene which reduces the affini...

journal_title：Neuroreport

authors： Koch M,Kling C,Becker CM

更新日期：1996-02-29 00:00:00

abstract：:Huntingtin, the protein product of the Huntington's disease gene, associates with vesicle membranes and microtubules in neurons. Analysis of axonal transport with a stop-flow, double crush ligation approach in rat sciatic nerve showed that full length huntingtin (350 kDa) and an N-terminal cleavage product (50 kD) wer...

journal_title：Neuroreport

authors： Block-Galarza J,Chase KO,Sapp E,Vaughn KT,Vallee RB,DiFiglia M,Aronin N

更新日期：1997-07-07 00:00:00

abstract：:It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...

journal_title：Neuroreport

authors： Vinader-Caerols C,Collado P,Segovia S,Guillamón A

更新日期：1998-08-03 00:00:00

abstract：:Using functional magnetic resonance imaging (fMRI), we investigated whether the response of auditory and visual cortex was modulated by attending selectively to either heard or seen numbers presented simultaneously. Alternating attention between modalities modulated fMRI signal within the corresponding sensory cortex....

journal_title：Neuroreport

authors： Woodruff PW,Benson RR,Bandettini PA,Kwong KK,Howard RJ,Talavage T,Belliveau J,Rosen BR

更新日期：1996-08-12 00:00:00

abstract：:Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few...

journal_title：Neuroreport

authors： Minamino K,Adachi Y,Yamada H,Higuchi A,Suzuki Y,Iwasaki M,Nakano K,Koike Y,Mukaide H,Kiriyama N,Shigematsu A,Matsumura M,Ikehara S

更新日期：2005-08-22 00:00:00

abstract：:To detect stress responses of the brain to subarachnoid hemorrhage (SAH), we investigated the expression of immediate early genes (IEGs) and hsp70 mRNA by in situ hybridization. Experimental SAH was produced in 49 rats by endovascular penetration. We also monitored the intracranial pressure (ICP) changes. The genes c-...

journal_title：Neuroreport

authors： Harada S,Kamiya K,Masago A,Iwata A,Yamada K

更新日期：1997-10-20 00:00:00

abstract：:In a three-stimulus oddball task, the amplitude of P3a elicited by deviant stimuli increases with an increase in the difficulty of discriminating between standard and target stimuli (i.e. task-difficulty effect on P3a), indicating that attentional capture by deviant stimuli is enhanced with an increase in task difficu...

journal_title：Neuroreport

authors： Sugimoto F,Kimura M,Takeda Y,Katayama J

更新日期：2017-08-16 00:00:00

abstract：:Previous functional neuroimaging studies of attention have emphasized the visual modality. We developed an auditory version of the continuous performance test (CPT) that included simple, focused and divided attention conditions. Positron emission tomographic (PET) scans were acquired during CPT performance in normal y...

journal_title：Neuroreport

authors： Benedict RH,Lockwood AH,Shucard JL,Shucard DW,Wack D,Murphy BW

更新日期：1998-01-05 00:00:00

abstract：:Other-race faces are less accurately recognized than same race faces but classified faster by race. Using event-related potentials (ERPs), we captured the brain temporal dynamics of face classification by race processing performed by 12 Caucasian participants. As expected, participants were faster to classify by race ...

journal_title：Neuroreport

authors： Caldara R,Rossion B,Bovet P,Hauert CA

更新日期：2004-04-09 00:00:00

abstract：:During the development of central nervous system, radial glial cells support target-specific neuronal migration. We recently reported that after implantation of chitosan channels with complete spinal cord transection, the tissue bridging the spinal cord stumps contained axons and radial glial cells. The purpose of thi...

journal_title：Neuroreport

authors： Nomura H,Kim H,Mothe A,Zahir T,Kulbatski I,Morshead CM,Shoichet MS,Tator CH

更新日期：2010-09-15 00:00:00

abstract：:We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...

journal_title：Neuroreport

authors： Abe S,Mizusawa I,Kanno K,Yabashi A,Suto M,Kuraya M,Honda T,Hiraiwa K

更新日期：2003-12-02 00:00:00

abstract：:Surface texture can be perceived not only from tactile, but also from auditory and visual sensory cues. In our previous psychophysical study, we demonstrated that humans can recognize surface stickiness using only one kind of sensory modality without any difficulty. However, the brain regions that would be activated b...

journal_title：Neuroreport

authors： So Y,Kim SP,Kim J

更新日期：2020-03-25 00:00:00

abstract：:Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...

journal_title：Neuroreport

authors： Hösli L,Hösli E,Winter T,Stauffer S

更新日期：1994-07-21 00:00:00

abstract：:We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmo...

journal_title：Neuroreport

authors： Rusovan A,Kanje M

更新日期：1992-09-01 00:00:00

abstract：:Stimulation of the Schaffer collateral projection to the CA1 region in rat hippocampal slices at 1 Hz for 15 min produced a N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) of synaptic responses and, when given after tetanic stimulation, reversed long-term potentiation (LTP). Both LTD and the ...

journal_title：Neuroreport

authors： Izumi Y,Zorumski CF

更新日期：1993-09-01 00:00:00

abstract：:The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-s...

journal_title：Neuroreport

authors： Peña-Rangel MT,Riesgo-Escovar JR,Sánchez-Chávez G,Salceda R

更新日期：2008-08-27 00:00:00

abstract：:Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm...

journal_title：Neuroreport

authors： Tani M,Onimaru H,Ikeda K,Kawakami K,Homma I

更新日期：2010-12-08 00:00:00

abstract：:The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure phase, D1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the...

journal_title：Neuroreport

authors： Crawford CA,Drago J,Watson JB,Levine MS

更新日期：1997-07-28 00:00:00

abstract：:We have previously suggested that progranulin mediates the stimulatory effects of estrogen on adult neurogenesis in the hippocampus. Neurogenesis in mature animals is enhanced by growth factors, environmental enrichment, and voluntary exercise. In this study, we investigated the role of progranulin in voluntary runnin...

journal_title：Neuroreport

authors： Asakura R,Matsuwaki T,Shim JH,Yamanouchi K,Nishihara M

更新日期：2011-12-07 00:00:00