Abstract:
:Voltage-dependent outward currents were examined in CA1 neurones by whole-cell recording in slices. Nine cells were recorded with the 'standard' internal solution (KMeSO4, HEPES, EGTA, CaCl2, and MgCl2) and held a potential (-54 +/- 3 mV) at which there was no significant outward current. Cromakalim (CROM, 100 microM) reduced both input conductance (GN) (by 14 +/- 4%) and outward currents, evoked over a wide range of potentials by brief depolarizing pulses: at -4.0 +/- 3.0 mV, currents diminished by 30 +/- 10%. When 1 mM GDP was added to the standard internal solution, there was a significant outward current at approximately -54 mV; and CROM greatly increased outward currents near -4.0 mV (by 99 +/- 26.4%, n = 10). The enhanced outward currents were reduced by CROM washout (in two cells) and by 10 microM glyburide (GLYB, in four cells). When six other cells were recorded with electrodes containing both ATP (5 mM) and GDP (1 mM), there was no net outward current at approximately -54 mV and CROM reduced outward currents (at approximately 0 mV, by 37.5 +/- 10.9%). We conclude that GDP in hippocampal neurones appears to activate an ATP- and GLYB-sensitive outward current, which is much potentiated by CROM.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Erdemli G,Krnjević Ksubject
Has Abstractpub_date
1994-06-27 00:00:00pages
1362-4issue
11eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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