Abstract:
:We investigated the expression for fibroblast growth factor-2 (FGF-2), in cultured rat cerebellar granule cells and its modulation by Ca2+ regulating agents. There were no significant differences in the levels of FGF-2 mRNA in cells cultured in high vs low K+. The expression of the trophic factor is induced by Ca2+ entry through the plasma membrane only in mature neurons but not at an early stage of maturation. Conversely the release of Ca2+ from intracellular stores increased the expression for FGF-2 at 2 or 7 days in culture. suggesting that is not dependent upon cellular maturation. These results suggest that specialized mechanisms can operate to regulate FGF-2 expression and that the integration of electrical and receptor-mediated signals for its modulation within cerebellar granule neurons may depend upon the maturational stage of the cells.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Roceri M,Molteni R,Racagni G,Riva MAdoi
10.1097/00001756-200011090-00043subject
Has Abstractpub_date
2000-11-09 00:00:00pages
3615-9issue
16eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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