Calcium-dependent modulation of FGF-2 expression in cultured cerebellar granule neurons.

Abstract:

:We investigated the expression for fibroblast growth factor-2 (FGF-2), in cultured rat cerebellar granule cells and its modulation by Ca2+ regulating agents. There were no significant differences in the levels of FGF-2 mRNA in cells cultured in high vs low K+. The expression of the trophic factor is induced by Ca2+ entry through the plasma membrane only in mature neurons but not at an early stage of maturation. Conversely the release of Ca2+ from intracellular stores increased the expression for FGF-2 at 2 or 7 days in culture. suggesting that is not dependent upon cellular maturation. These results suggest that specialized mechanisms can operate to regulate FGF-2 expression and that the integration of electrical and receptor-mediated signals for its modulation within cerebellar granule neurons may depend upon the maturational stage of the cells.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Roceri M,Molteni R,Racagni G,Riva MA

doi

10.1097/00001756-200011090-00043

subject

Has Abstract

pub_date

2000-11-09 00:00:00

pages

3615-9

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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