Abstract:
:According to the previous research, metformin, a medication utilized for type 2 diabetes management, inhibits neural aging and reduces infarct size by enhancing angiogenesis in a mouse stroke model. What is more, metformin administration also promotes neural precursor cells proliferation, migration, as well as differentiation for newborn mice with hypoxia-ischemia brain injury. However, whether metformin regulates neurogenesis in an adult rat ischemia/reperfusion (I/R) model remains unclear. The current research found that metformin administration reduced neuronal damage in the CA1 area of hippocampus in a rat model of I/R. The number of neuronal nuclei positive neuron was significantly increased and glial fibrillary acidic protein positive astrocyte became obviously declined in the CA1 region in I/R rats treated with metformin. It was further demonstrated that metformin promoted neuroblasts proliferation and neuronal differentiation in the subgranular zone of the dentate gyrus and inhibited the formation of astrocyte. Our study indicates that activation of endogenous neuroblasts using metformin will become a favorable target in therapeutic intervention of cerebral ischemia injury models.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yuan R,Wang Y,Li Q,Zhen F,Li X,Lai Q,Hu P,Wang X,Zhu Y,Fan H,Yao Rdoi
10.1097/WNR.0000000000001190subject
Has Abstractpub_date
2019-02-06 00:00:00pages
232-240issue
3eissn
0959-4965issn
1473-558Xjournal_volume
30pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Fragile X syndrome is a neurodevelopmental disorder caused by a trinucleotide (CGG) hyperexpansion in the FMR1 gene, functionally silencing transcription of the fragile X mental retardation protein (FMRP). This disorder is characterized by impaired cognition, communication, and social behavior. The aim of this study w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000701
更新日期:2016-12-14 00:00:00
abstract::Some of the most extensively used fluorophores for multicolour fluorescence labelling of tissue, such as Lucifer yellow, fluorescein, Cyanine-3.18 and rhodamine, all have the disadvantage of being difficult to separate spectrally due to their broad and overlapping emission spectra. With the intensity-modulated multipl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505300-00024
更新日期:1995-05-30 00:00:00
abstract::We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the presence of the metabolic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833e332d
更新日期:2010-10-06 00:00:00
abstract::Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199612200-00010
更新日期:1996-12-20 00:00:00
abstract::The effect of olfactory deprivation on cellular expression of the Bcl-2 gene in the olfactory bulb of young rats was investigated. Restriction of olfactory stimuli caused an overall increase in Bcl-2 mRNA expression, with increases seen in the lateral aspects of glomerular, external plexiform, mitral and granule cell ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Deficiencies of Ca2+ homeostasis are proposed to play an important role in neuronal ageing and/or neurodegeneration. The aim of this study was to investigate, in a defined neuronal population, primary cerebellar granule neuron culture, the time-dependent changes in Ca2+ homeostasis and compare them with data obtained ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011270-00027
更新日期:2000-11-27 00:00:00
abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199206000-00004
更新日期:1992-06-01 00:00:00
abstract::Event-related potentials were recorded in healthy volunteers to test the accuracy of the human brain to extract, preattentively, auditory abstract rules. The abstract rule was determined by the frequency relationship between two pure tones forming a pair. The standard pairs had identical tone frequency, whereas the de...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200502280-00020
更新日期:2005-02-28 00:00:00
abstract::The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure phase, D1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707280-00021
更新日期:1997-07-28 00:00:00
abstract::Music is an essential communication tool that can convey emotional information. Segmentation of a sound stream of music at event boundaries is necessary for identification and extraction of musical context and features. To investigate recognition of music termination structure, or cadence, we composed music sequences ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000160
更新日期:2014-07-09 00:00:00
abstract::Early left-hemispheric brain lesions may lead to a reorganization of language into the right hemisphere. Language functions are consecutively spared, but visuospatial functions show slight deficits. Cortical 'crowding' of the right hemisphere has been suggested as an explanation for this effect, but no direct evidence...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000221841.12632.d6
更新日期:2006-06-26 00:00:00
abstract::Reorganization of motor execution and imagination networks was studied in six patients with unilateral dystonia secondary to a subcortical stroke and compared with seven control subjects using fMRI. Patients performed imagined and real auditory-cued hand movements. Movements of the dystonic hand resulted in overactivi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200408260-00010
更新日期:2004-08-26 00:00:00
abstract::We recently reported behavioral improvements following intrastriatal transplantation of cryopreserved cultured human neuroteratocarcinoma-derived cells (hNT neurons) in rats with cerebral ischemia induced by occlusion of the middle cerebral artery. In the present study, the viability and survival of hNT neurons were e...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00028
更新日期:1998-08-24 00:00:00
abstract::The potent and selective AMPA receptor antagonist NBQX was tested for cytoprotective properties in an adult rat model of transient focal neocortical ischemia. Nineteen spontaneously hypertensive rats sustained 2 h of middle cerebral artery occlusion, followed by 22 h of recirculation. Ninety minutes following the onse...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199108000-00016
更新日期:1991-08-01 00:00:00
abstract::Upon perfusion with Mg2+-free artificial cerebrospinal fluid (ACSF) organotypic hippocampal slice cultures develop seizure-like events and tonic recurrent discharges in which areas CA3 and CA1 and, in contrast to acute slices, also the dentate gyrus (DG) participate. Using the fluorescent dye propidium iodide (PI) we ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00002
更新日期:1999-02-05 00:00:00
abstract::Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated. Neuroligins (NLs), as a family of cell-adhesion proteins, are involved in synaptic formation and have been linked to various neuropsychiatric disorders. Here, we studied the a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001045
更新日期:2018-07-04 00:00:00
abstract::Systemic administration of DL-fenfluramine (20 mg kg-1), an indirect serotonergic agonist, induced widespread FOS-like protein in the rat caudate putamen (CPu), paraventricular nucleus (PVn) of the hypothalamus and several intralaminar thalamic nuclei. To ascertain whether the dopaminergic nigrostriatal system coordin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199508000-00021
更新日期:1995-08-21 00:00:00
abstract::Animal models suggest that the asymmetry of monocular optokinetic nystagmus (OKN) in young infants can be explained by a direct pathway from retina to the midbrain nucleus of the optic tract. However, earlier studies with hemispherectomized infants showed no evidence for OKN responses towards the damaged cortex that c...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909090-00006
更新日期:1999-09-09 00:00:00
abstract::The whole-cell patch clamp technique was used to investigate the actions of the opioid agonist U50488H on Ca2+ and K+ currents in differentiated NG108-15 cells. U50488H (5-50 microM) caused a concentration-dependent, reversible inhibition of high voltage-activated Ca2+ currents which persisted in the presence of nifed...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199607290-00024
更新日期:1996-07-29 00:00:00
abstract::This study examined the effects of cocaine HCl and ambient temperature on the core body temperature of the rat. To further examine the mechanisms of cocaine-induced changes in temperature regulation, the effects of cocaine on behavioral thermoregulatory responses were also observed. At normal room temperature (20 degr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199301000-00028
更新日期:1993-01-01 00:00:00
abstract::Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophren...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000221828.10846.ba
更新日期:2006-07-17 00:00:00
abstract::Dysfunctional glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia. Abnormal expressions in schizophrenia of ionotropic glutamate receptors (iGluRs) and the proteins that regulate their trafficking have been found to be region and subunit specific in brain, suggesting that abnormal t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328363bd8a
更新日期:2013-08-21 00:00:00
abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00037
更新日期:2001-07-20 00:00:00
abstract::To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid releas...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200210280-00026
更新日期:2002-10-28 00:00:00
abstract::Topiramate is a structurally novel neurotherapeutic agent with a unique combination of pharmacological properties and currently is available in most world markets for treating several seizure disorders. Because its pharmacological profile was suggestive of possible activity as a neuroprotectant, topiramate was evaluat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00033
更新日期:2001-04-17 00:00:00
abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00016
更新日期:2002-09-16 00:00:00
abstract::The purpose of this study was to determine whether the system that underlies the mismatch negativity (MMN) of event-related potentials would operate on the basis of objects if stimuli were delivered in such a way as to create the impression of two objects. To this end, tones were alternated between ears with one combi...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200001170-00012
更新日期:2000-01-17 00:00:00
abstract::Compartmental models of thalamic reticular (RE) neurons were investigated based on current-clamp and voltage-clamp data. Spontaneous oscillations in the model arise from the interaction between inhibitory synaptic currents and the rebound burst of RE cells. These oscillations critically depend on the level of the rest...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199411000-00003
更新日期:1994-11-21 00:00:00
abstract::Human somatosensory evoked potentials (SEP) contain high-frequency (600 Hz) wavelet bursts possibly reflecting repetitive population spikes in thalamocortical axons and/or postsynaptic responses. To dissociate thalamic and cortical burst components the recovery of intrathalamic SEP (derived from electrodes implanted f...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200004270-00030
更新日期:2000-04-27 00:00:00
abstract::In order to assess effects of glucagon-like peptide-1 (GLP-1) in the brain excluding the hypothalamus, the effects of GLP-1 (7-36) amide, a naturally produced active fragment, on the electroencephalogram and hippocampal single unit activities of anesthetized male Wistar rats were examined. I.c.v. injection of GLP-1 (7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00004
更新日期:1999-06-03 00:00:00