Abstract:
:Systemic administration of DL-fenfluramine (20 mg kg-1), an indirect serotonergic agonist, induced widespread FOS-like protein in the rat caudate putamen (CPu), paraventricular nucleus (PVn) of the hypothalamus and several intralaminar thalamic nuclei. To ascertain whether the dopaminergic nigrostriatal system coordinated transcriptional effects on the CPu, discrete microinjections of dextran into the substantia nigra (cell group A9) were evaluated for retrograde axonal transport. The protein product was induced preferentially in medium-sized spiny nerve cells of the CPu. Dextran microinjections into the PVn demonstrated that perikarya bearing FOS-like protein projected their extensions directly to thalamic nuclei and indirectly to immunopositive neurons of the striatum. The significance of these latter results is discussed in terms of a possible dopaminergic mechanism.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Torres Gdoi
10.1097/00001756-199508000-00021subject
Has Abstractpub_date
1995-08-21 00:00:00pages
1679-83issue
12eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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