BDNF, but not NT-3, promotes long-term survival of axotomized adult rat corticospinal neurons in vivo.

abstract：:The inward rectifier Kir4.1, composed of KCNJ10 K channel subunits, plays an essential role in inner ear K homeostasis. We have investigated the developmental expression and localization of KCNJ10 (Kir4.1) in the guinea pig inner ear using semi-quantitative reverse transcription polymerase chain reaction and immunohis...

journal_title：Neuroreport

authors： Jin Z,Wei D,Järlebark L

更新日期：2006-04-03 00:00:00

abstract：:Human neuroblastoma SH-SY5Y and small-cell lung carcinoma U1690 cells of neuroendocrine origin were exposed to morphine for 1 h, 3 h or 5 days. These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells. Five-day morphine treatment,...

journal_title：Neuroreport

authors： Bakalkin G,Yakovleva T,Melzig M,Terenius L

更新日期：1997-07-07 00:00:00

abstract：:Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases ...

journal_title：Neuroreport

authors： Lazar SW,Bush G,Gollub RL,Fricchione GL,Khalsa G,Benson H

更新日期：2000-05-15 00:00:00

abstract：:This study used electroencephalogram measurements to investigate the effects of aging on oscillatory theta modulation during an audiovisual discrimination task. By a wavelet-based time-frequency analysis, age-related theta oscillation response differences were observed within a relatively restricted time range (0-500 ...

journal_title：Neuroreport

authors： Yan T,Bi X,Zhang M,Wang W,Yao Z,Yang W,Wu J

更新日期：2016-08-03 00:00:00

abstract：:The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements reveal...

journal_title：Neuroreport

authors： Salas C,Navarro F,Torres B,Delgado-Garcia JM

更新日期：1992-02-01 00:00:00

abstract：:Prior work has shown that kappa opioids may attenuate the effects of analgesic mu receptor agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia following exposure to a signal for shock is attenuated by infusions of the kappa agonist U69593 into the rostral ventromedial m...

journal_title：Neuroreport

authors： Foo H,Helmstetter FJ

更新日期：2000-10-20 00:00:00

abstract：:The aim of this study was to investigate whether frontal lobe damage affects thalamic volume in humans. Ipsilateral and contralateral thalamic areas were measured in 0.5T T1-weighted sagittal magnetic resonance images in 12 patients, first at the time of their surgery for relief of a unilateral frontal lobe brain tumo...

journal_title：Neuroreport

authors： Hulshoff Pol HE,van der Flier WM,Schnack HG,Tulleken CA,Ramos LM,van Ree JM,Kahn RS

更新日期：2000-09-11 00:00:00

abstract：:Ischemic stroke is the most frequent cause of long-term morbidity and mortality in the elderly worldwide. Mild hypothermia (32-35°C) has been found to have a neuroprotective effect against ischemic stroke. However, the protective mechanisms remain unclear. In the present study, we explore the neuroprotective effect of...

journal_title：Neuroreport

authors： Gao Z,Zhang Z,Bian Q,Li Y,Ma D,Liu Z,Zhang S

更新日期：2021-01-18 00:00:00

abstract：:We investigated the cardiovascular effects of bilateral microinjection of antisense oligodeoxynucleotides (oligos) into the nucleus tractus solitarii (NTS) to neuronal nitric oxide synthase (nNOS) to suppress the expression of nNOS molecular biologically. In urethane-anesthetized, paralyzed Wistar-Kyoto rats, bilatera...

journal_title：Neuroreport

authors： Maeda M,Hirano H,Kudo H,Doi Y,Higashi K,Fujimoto S

更新日期：1999-06-23 00:00:00

abstract：:In situ hybridization has demonstrated mRNA for olfactory receptors (OR) in the axon terminals of olfactory receptor neurons. Neurons that express the same OR appear to send their axons to two stereotyped glomeruli in the olfactory bulb (OB). Based on these observations, we tested the feasibility of using RT-PCR to is...

journal_title：Neuroreport

authors： Singer MS,Hughes TE,Shepherd GM,Greer CA

更新日期：1998-11-16 00:00:00

abstract：:It has been reported that intracerebroventricular (i.c.v.) injection of nociception/orphanin FQ (OFQ) can antagonize morphine analgesia, whereas i.c.v. OFQ antibody can reverse morphine tolerance. Nocistatin (NST) is a recently characterized neuropeptide possessing an antagonizing effect on OFQ. Here we examine whethe...

journal_title：Neuroreport

authors： Sun RQ,Zhao CS,Wang HJ,Jing Z,Wang W,Yang K,Wang Y,Chang JK,Han JS

更新日期：2001-06-13 00:00:00

abstract：:Statistical analysis on diffusion tensor imaging has been used extensively in mesial temporal lobe epilepsy (mTLE) and most studies report decrease in fractional anisotropy (FA) in multiple white matter regions. However, these findings vary across studies and between regions. Therefore, in this study, we used tract-ba...

journal_title：Neuroreport

authors： An J,Fang P,Wang W,Liu Z,Hu D,Qiu S

更新日期：2014-07-09 00:00:00

abstract：:Interleukin-2 and its receptors are present in hippocampal structures, particularly the pyramidal cell layer. In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique. RhIL-2 depressed ...

journal_title：Neuroreport

authors： Plata-Salamán CR,ffrench-Mullen JM

更新日期：1993-05-01 00:00:00

abstract：:Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg mo...

journal_title：Neuroreport

authors： Sharpe LG,Jaffe JH

更新日期：1990-09-01 00:00:00

abstract：:GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...

journal_title：Neuroreport

authors： Macnab LT,Williams SM,Pow DV

更新日期：2006-12-18 00:00:00

abstract：:NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, ...

journal_title：Neuroreport

authors： Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom M

更新日期：2000-08-03 00:00:00

abstract：:The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...

journal_title：Neuroreport

authors： Dewil M,Schurmans C,Starckx S,Opdenakker G,Van Den Bosch L,Robberecht W

更新日期：2005-03-15 00:00:00

abstract：:Neurone-specific enolase immunoreactivity (NSE-IR) was examined in the hippocampal dentate gyrus 5 h, 24 h and 6 days following local injection of N-methyl-D-aspartate (NMDA), and was compared with Nissl substance and acid fuchsin staining. Five and 24 hours post-injection extracellular NSE-IR was increased, and the n...

journal_title：Neuroreport

authors： Comer AM,Lees GJ,Lipski J

更新日期：1994-12-20 00:00:00

abstract：:An fMRI investigation was conducted to determine whether patients with impaired face recognition, a deficit known as prosopagnosia, would show functional activation in the fusiform gyrus, the neural substrate for face processing, when viewing faces. While the patients did show activation in the fusiform gyrus, with si...

journal_title：Neuroreport

authors： Marotta JJ,Genovese CR,Behrmann M

更新日期：2001-06-13 00:00:00

abstract：:The aim was to study the effects of an NMDA receptor antagonist on caspase-3 activation and DNA fragmentation after hypoxia-ischemia (HI) in 7-day-old rats. Animals were treated with vehicle or MK-801 (0.5 mg/kg) directly after HI and sacrificed 8, 24 or 72h later. MK-801 reduced injury (by 53%), cells positive for ac...

journal_title：Neuroreport

authors： Puka-Sundvall M,Hallin U,Zhu C,Wang X,Karlsson JO,Blomgren K,Hagberg H

更新日期：2000-09-11 00:00:00

abstract：:We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...

journal_title：Neuroreport

authors： Watanabe N,Ishii K,Hotta H,Oda K,Sakata M,Toyohara J,Ishiwata K

更新日期：2013-05-29 00:00:00

abstract：:Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...

journal_title：Neuroreport

authors： Matsuoka N,Aigner TG

更新日期：1996-01-31 00:00:00

abstract：:Brain membrane phospholipid fatty acid composition is investigated in Alzheimer's disease using fresh pathologically proven autopsy material. The most striking abnormalities in Alzheimer brains compared to age-matched controls are found in the n - 6 line of polyunsaturated fatty acids (PUFA) showing an elevation of 18...

journal_title：Neuroreport

authors： Nakada T,Kwee IL,Ellis WG

更新日期：1990-10-01 00:00:00

abstract：:We examined covert and overt orienting in response to non-predictive gaze direction cues and investigated whether the subcortical superior colliculus (SC) plays a role in this type of orienting. Participants viewed a centrally presented gazing schematic face and responded to targets appearing at gazed-at or non-gazed-...

journal_title：Neuroreport

authors： Friesen CK,Kingstone A

更新日期：2003-03-03 00:00:00

abstract：:Voltage-gated K+ channels (K(V)) regulate cell electrical properties, proliferation, migration, and death. Rotenone is a mitochondrial inhibitor, influencing activity of many channels that potentially participate in cell death processes, but its effect on K(V) channel in neurons remains unclear. This study used whole-...

journal_title：Neuroreport

authors： Gao XF,Wang W,He C

更新日期：2008-09-17 00:00:00

abstract：:High K+- or caffeine-induced Ca2+ signal was studied in freshly dissociated carp retinal ON-type bipolar cells using a confocal laser-scanning microscope. In response to 35 mM K+ exposure, a rise in [Ca2+]i appeared in both the terminal and soma, but was absent after removal of external Ca2+ or in the presence of 100 ...

journal_title：Neuroreport

authors： Wu D,Zhu PH

更新日期：1999-12-16 00:00:00

abstract：:Cells overexpressing the beta-amyloid precursor protein possessing a mutation found in familial Alzheimer's disease overproduce beta-amyloid peptide (A beta). Because these findings were based on immunological identification, we have chemically characterized the peptides produced. Purified A beta fragments from the co...

journal_title：Neuroreport

authors： Dovey HF,Suomensaari-Chrysler S,Lieberburg I,Sinha S,Keim PS

更新日期：1993-08-01 00:00:00

abstract：:Using cRNA in situ hybridization, the regional distribution of mRNA encoding the human Y1 receptor was investigated in the normal human brain and compared with the autoradiographic distribution of putative Y1/[125I][Leu31,Pro34]PYY binding sites. Surprisingly, relatively high levels of Y1 receptor mRNA, distributed in...

journal_title：Neuroreport

authors： Jacques D,Tong Y,Dumont Y,Shen SH,Quirion R

更新日期：1996-04-10 00:00:00

abstract：:Impaired print tuning in dyslexia has been shown in alphabetic languages; whether we can observe the same in a nonalphabetic language such as Chinese is still questionable. The present study investigated the N170 component in response to Chinese words versus nonword pseudo-words in 10-year-old children with developmen...

journal_title：Neuroreport

authors： Zhou L,Yan X

更新日期：2018-10-17 00:00:00

abstract：:A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...

journal_title：Neuroreport

authors： Seutin V,Massotte L,Renette MF,Dresse A

更新日期：2001-02-12 00:00:00