Abstract:
:NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, diminishes along sulcal wall, and is barely detectable in sulcal floor cortex. In contrast, in some cases, immunoreactivity in laminae V and VI pyramidal neurons shows the reverse pattern. Neurofilament and calretinin immunoreactivity do not show this phenomenon. The findings suggest novel functional regionalization at the sulcogyral level in normal human brain.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom Mdoi
10.1097/00001756-200008030-00050subject
Has Abstractpub_date
2000-08-03 00:00:00pages
2601-6issue
11eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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