Abstract:
:Voltage-gated K+ channels (K(V)) regulate cell electrical properties, proliferation, migration, and death. Rotenone is a mitochondrial inhibitor, influencing activity of many channels that potentially participate in cell death processes, but its effect on K(V) channel in neurons remains unclear. This study used whole-cell patch clamp methods and found that rotenone concentration dependently decreased delayed rectifier K+ current (I(DR)) amplitude in cultured ventral mesencephalic neurons, but had no effect on A-type current (I(A)) peak amplitude. Furthermore, the protein kinase A inhibitor H-89 prevented rotenone-induced decrease in I(DR). The inhibition of I(DR) by rotenone was mimicked by extracellular application of forskolin. In summary, our results indicate that rotenone acutely decreased I(DR) currents in cultured mesencephalic neurons via a protein kinase A-dependent mechanism.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gao XF,Wang W,He Cdoi
10.1097/WNR.0b013e32830d149esubject
Has Abstractpub_date
2008-09-17 00:00:00pages
1401-5issue
14eissn
0959-4965issn
1473-558Xpii
00001756-200809170-00011journal_volume
19pub_type
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