Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients.

Abstract:

:Using quantitative autoradiography, the present study examined ionotropic glutamatergic receptor binding sites using [3H]dizocilpine, [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate, and [3H]kainate in the posterior cingulate cortex of schizophrenia patients and matched controls. We found a significant increase in [3H]dizocilpine binding in the superficial layers (41%, p<0.001) and deep layers (30%, p=0.004) of the posterior cingulate cortex in the schizophrenia group compared with controls. No significant differences were observed in [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and [3H]kainate binding. In summary, the present study has for the first time demonstrated that the glutamatergic system is affected in the posterior cingulate cortex in schizophrenia patients. The fact that only the N-methyl-D-aspartate receptor densities are significantly altered suggests that this is unlikely to be caused by a simple decrease in glutamatergic transmission.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Newell KA,Zavitsanou K,Huang XF

doi

10.1097/01.wnr.0000174056.11403.71

subject

Has Abstract

pub_date

2005-08-22 00:00:00

pages

1363-7

issue

12

eissn

0959-4965

issn

1473-558X

pii

00001756-200508220-00021

journal_volume

16

pub_type

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