Abstract:
:Peripheral nervous system injury may be corrected by surgical repair, but in many cases this is not possible and will result in loss of motor and sensory function. Schwann cells provide many neurotrophic signals essential for axon regeneration and immediately after injury inflammatory cytokines are released necessary for Schwann cell de-differentiation. However, extended periods of inflammation after injury prevent Schwann cell proliferation, and therefore interventional approaches to enhance proliferation may in turn improve axon regeneration. We therefore investigated the ability of alpha-melanocyte stimulating hormone (alpha-MSH; a potent anti-inflammatory peptide) to inhibit the activation of the NF-kappaB transcription factor (required for inflammatory signalling) in cultured rat primary Schwann cells, stimulated with tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma). Both cytokines activated NF-kappaB rapidly after 60 min incubation, observed as a translocation from the cytoplasm to the nucleus. alpha-MSH inhibited activation (i.e. inhibited nuclear translocation) in response to TNF-alpha or IFN-gamma by 81% and 100% respectively. The anti-inflammatory properties of this peptide may therefore have potential for treatment of peripheral nerve injury to improve the healing response.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Teare KA,Pearson RG,Shakesheff KM,Haycock JWdoi
10.1097/00001756-200403010-00022subject
Has Abstractpub_date
2004-03-01 00:00:00pages
493-8issue
3eissn
0959-4965issn
1473-558Xpii
00001756-200403010-00022journal_volume
15pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::This study examined the hypothesis that cholinergic receptor mechanisms within the gigantocellular tegmental field (FTG) of the medial pontine reticular formation can cause state-dependent changes in the firing rates of parabrachial nuclear complex (PBNC) neurons. Using intact, unanesthetized cats, long-term recording...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199303000-00011
更新日期:1993-03-01 00:00:00
abstract::Recently, there has been growing interest in the neurobiological role of some amygdalar neuromediators, such as GABA and orexins (ORX), that are responsible for stressful behaviors. Infusion of the major fear-related and panic-related basolateral amygdalar station, the lateral nucleus, with ORX-A and ORX-B, alone or i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000213
更新日期:2014-08-20 00:00:00
abstract::Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001431
更新日期:2020-04-08 00:00:00
abstract::Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283495acc
更新日期:2011-08-24 00:00:00
abstract::To test the combined effect of high glucose and decreased Na+/K+-pump activity, a condition which closely mimics the diabetic state, on nerve ionic currents, changes in action potential and membrane current induced by high glucose in the presence of ouabain were investigated using voltage clamp analysis in rat single ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008030-00040
更新日期:2000-08-03 00:00:00
abstract::In order to assess effects of glucagon-like peptide-1 (GLP-1) in the brain excluding the hypothalamus, the effects of GLP-1 (7-36) amide, a naturally produced active fragment, on the electroencephalogram and hippocampal single unit activities of anesthetized male Wistar rats were examined. I.c.v. injection of GLP-1 (7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00004
更新日期:1999-06-03 00:00:00
abstract::Galanin, oxytocin and cholecystokinin (CCK) are peptides that influence feeding behaviour. Galanin has been found to stimulate food intake and oxytocin and CCK have been suggested to be satiety agents. The present study was performed in order to investigate if galanin influences the secretion of oxytocin and CCK as a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199301000-00002
更新日期:1993-01-01 00:00:00
abstract::Inhibitory deficits are one of the predominant causes of cognitive aging. This study examined age-related changes in response inhibition. In this study, young and older participants performed a bimanual/bipedal response inhibition task while we measured their brain activity via functional near-infrared spectroscopy. P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001516
更新日期:2020-10-07 00:00:00
abstract::This study investigated the functional neuroanatomy involved in retrieval of structured versus unstructured verbal information. We compared cerebral blood flow using PET with the [15O]water method while subjects engaged in recall of novel and practised narratives and lists of unrelated words. Left orbital frontal cort...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199709290-00017
更新日期:1997-09-29 00:00:00
abstract::The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to coca...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199101000-00013
更新日期:1991-01-01 00:00:00
abstract::Paraoxonase polymorphisms have been associated with amyotrophic lateral sclerosis (ALS). Paraoxonases are detoxifying enzymes involved in the metabolism of organophosphates. We tested the hypothesis that genetic variation within paraoxonase genes would interact with the environmental exposure to paraoxonase substrates...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831af220
更新日期:2009-01-28 00:00:00
abstract::Expression of monocarboxylate transporter MCT1 was studied in archival tissues from human CNS using antibodies to the carboxyl-terminal end of MCT1. Sections of neocortex, hippocampus and cerebellum of brains from 10 adult autopsy patients who died from other than CNS disease, and from archival surgical biopsy specime...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00030
更新日期:2001-03-26 00:00:00
abstract::Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199907130-00008
更新日期:1999-07-13 00:00:00
abstract::Semi-quantitative single cell RT-PCR techniques were used to determine the expression of mRNAs related to GABAergic and cholinergic neurotransmission in neurons of the rat globus pallidus and adjacent basal forebrain region. Neurons of the globus pallidus expressed relatively high levels of GAD67 and GABA vesicular tr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00004
更新日期:1998-06-22 00:00:00
abstract::It is not clear whether attention is necessary or not for consciousness. We studied the relationship between attention and consciousness by tracking their electrophysiological correlates. The participants attended to visual targets, ignored nontargets in the prespecified visual field and ignored all stimuli in the opp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c143c8
更新日期:2007-05-28 00:00:00
abstract::Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000373
更新日期:2015-06-17 00:00:00
abstract::In acute experiments, the effects of i.p. 17beta-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17Beta-estradiol (100 microg/100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25 min. In some neurons spontaneous activity could be influ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00034
更新日期:1999-11-26 00:00:00
abstract::Prepulse inhibition (PPI) of the acoustic startle reflex is a measure of sensorimotor gating which occurs in both rodents and humans. PPI is deficient in severe neuropsychiatric disorders such as schizophrenia. We investigated PPI in 10 adult monkeys (Cebus apella). Stimuli were 115 dB white noise startle pulses, eith...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00031
更新日期:2001-01-22 00:00:00
abstract::Functional MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain process in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Sex differences in event-related potentials were examined in 23 women and 24 men during a mental rotation task. We found an early (130-400 ms) and a late (400-700 ms) ERP mental rotation effect. The late rotation effect, which is thought to indicate the onset of the cognitive process of mental rotation, emerged about ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f519b3
更新日期:2008-02-12 00:00:00
abstract::We examined effects of trial averaging upon spatial extent, spatial topography, and temporal properties of fMRI activation. Two subjects participated in an event-related visual stimulation design. There was an exponential relation between number of trials and spatial extent, such that additional trials identified, on ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00025
更新日期:2001-08-08 00:00:00
abstract::It is well known that perceiving another person's body movements activates corresponding motor representations in an observer's brain, a process which appears to be imitative in nature. However, it is also true that simply imitating another person's action/s in many situations is not an effective or appropriate respon...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/WNR.0b013e3283630a66
更新日期:2013-08-07 00:00:00
abstract::A synchronizing volley of excitation was delivered to cells from the primary visual cortex of the anaesthetized cat by an electrical pulse stimulation of the optic radiations. In intracellular records, this resulted in an initial, fast depolarization of the membrane potential followed by a longer lasting (266 ms) hype...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004270-00020
更新日期:2000-04-27 00:00:00
abstract::Prism adaptation reduces some symptoms of neglect; however the mechanisms underlying such changes are poorly understood. We suggest that prisms influence neglect by acting on dorsal stream circuits subserving visuomotor control, with little influence on perceptual aspects of neglect. We examined prism adaptation in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328338592f
更新日期:2010-04-21 00:00:00
abstract::The current study investigated whether an ipsilesional bias in line bisection, a conventional measure for diagnosing hemispatial neglect, persists even in the absence of this syndrome in patients with chronic lesions restricted to posterior association cortex or dorsolateral prefrontal cortex. Both left and right hemi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199910190-00004
更新日期:1999-10-19 00:00:00
abstract::Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0b542
更新日期:2007-10-29 00:00:00
abstract::Functional imaging has struggled for two decades to establish a quantitative link between the neuronal activity and the change in signal obtained. This review proposes a division of neuronal activity into a component relating to the electrical discharge activity and a component relating to the size of the activated ne...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-200409150-00001
更新日期:2004-09-15 00:00:00
abstract::Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprussi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199305000-00001
更新日期:1993-05-01 00:00:00
abstract::The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distribute...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199101000-00002
更新日期:1991-01-01 00:00:00
abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP-22) gene which results in abnormal myelination of the peripheral nervous system. However, the clinical symptoms observed in the mutant suggest abnormalities in the central nervous system. Using the Northern blot te...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199406020-00015
更新日期:1994-06-02 00:00:00