Denervation impairs cutaneous microvascular function and blister healing in the rat hindlimb.

Abstract:

:Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprusside (SNP) evoked direct dilator responses. Resultant changes in skin microvascular blood flux were measured by laser Doppler flowmetry. Compared with their sham-operated control limbs, denervation reduced inflammatory responses (ACh or TNS) by more than 85% and SNP responses by 28% (p < 0.05). Healing of dry-ice blisters raised on the hindpaw 14d post-denervation was significantly slower to complete healing (42d) than controls (26d) and initial inflammation was attenuated, confirming that innervation is important for inflammation and blister-healing.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Carr RW,Delaney CA,Westerman RA,Roberts RG

doi

10.1097/00001756-199305000-00001

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

467-70

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

4

pub_type

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