Abstract:
:Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprusside (SNP) evoked direct dilator responses. Resultant changes in skin microvascular blood flux were measured by laser Doppler flowmetry. Compared with their sham-operated control limbs, denervation reduced inflammatory responses (ACh or TNS) by more than 85% and SNP responses by 28% (p < 0.05). Healing of dry-ice blisters raised on the hindpaw 14d post-denervation was significantly slower to complete healing (42d) than controls (26d) and initial inflammation was attenuated, confirming that innervation is important for inflammation and blister-healing.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Carr RW,Delaney CA,Westerman RA,Roberts RGdoi
10.1097/00001756-199305000-00001subject
Has Abstractpub_date
1993-05-01 00:00:00pages
467-70issue
5eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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