Electrophysiological correlates of reduced pain perception after theta-burst stimulation.

Abstract:

:In an earlier study, we reported the antinociceptive effects of a special repetitive transcranial magnetic stimulation paradigm: continuous theta-burst stimulation (cTBS), when applied to human motor cortex. Here, we investigated whether the reduced subjective pain perception of 10 healthy individuals could be measured by changes in laser-evoked potentials, a reflection of pain related activations in the operculoinsular and midcingulate cortex. To minimize the effect of habituation during repeated laser stimulation, a bioadaptive design was used. However, both pain ratings and laser-evoked potential amplitudes were reduced after real and sham cTBS. When compared with sham stimulation, cTBS resulted in a significantly greater diminution of pain ratings and N2-P2 amplitudes on the hand contralateral to the site of motor cortex stimulation.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Csifcsak G,Nitsche MA,Baumgärtner U,Paulus W,Treede RD,Antal A

doi

10.1097/WNR.0b013e32832e0c74

subject

Has Abstract

pub_date

2009-08-05 00:00:00

pages

1051-5

issue

12

eissn

0959-4965

issn

1473-558X

pii

00001756-200908050-00003

journal_volume

20

pub_type

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