Abstract:
:In this study, we have identified novel splice variants of the Na+ channel alpha subunit mRNA from cultured rat astrocytes and neuroblastoma cells. These splice variants are characterized by premature truncation or deletion of a segment in the third domain of the Na+ channel alpha subunit. The expression of three splice variants was upregulated by exposure to 1 mM dibutyryl cAMP in spinal cord astrocytes but not in cerebral astrocytes and in B50 and B104 neuroblastoma cells. The calcium ionophore 1 microM A23187, did not influence the expression of splice variants in either astrocytes or neuroblastoma cells. These findings suggest that spinal cord astrocytes may maintain a unique regulatory pathway that participates in the control of Na+ channel mRNA expression.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Oh Y,Waxman SGdoi
10.1097/00001756-199805110-00002subject
Has Abstractpub_date
1998-05-11 00:00:00pages
1267-72issue
7eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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