Extended brain disinhibition following small photothrombotic lesions in rat frontal cortex.


:The effect of an ischaemic focal cortical lesion on the excitability of surrounding and remote brain areas was investigated. Infarcts were produced photothrombotically in rat frontal cortex and brain excitability was assessed by a extracellular paired-pulse stimulation in coronal slices 7 days later. The cortical lesions caused a reduction of inhibition. The extent and grade of these electrophysiological effects depended on the depth of the lesion: in animals with a lesion affecting the deeper cortical layers a pronounced transcortical diaschisis was found, whereas animals with a shallow lesion showed only a slight ipsilateral affliction. The study shows that focal lesions in the motor cortex cause widespread disinhibition, probably resulting from deafferentation, and these may have a significant impact on recovery of function.






Buchkremer-Ratzmann I,Witte OW




Has Abstract


1997-01-20 00:00:00












  • Size-invariant representation of face in infant brain: an fNIRS-adaptation study.

    abstract::We studied whether 5-month-old to 8-month-old infants process faces in a size-invariant manner by applying the fNIRS-adaptation paradigm used in our previous study. We used near-infrared spectroscopy to measure hemodynamic responses in the temporal regions of infants' brains during the repeated presentation of an iden...


    pub_type: 杂志文章


    authors: Kobayashi M,Otsuka Y,Kanazawa S,Yamaguchi MK,Kakigi R

    更新日期:2012-12-05 00:00:00

  • Visually-triggered oscillations in the cat lateral posterior-pulvinar complex.

    abstract::The so-called 40 Hz oscillations are found at almost all stages of visual processing are thought to play a critical role in perception. The goal of this investigation was to look at the presence of stimulus-specific oscillations in the lateral posterior-pulvinar complex of the thalampus (LP-P) for which the oscillatio...


    pub_type: 杂志文章


    authors: Shumikhina S,Molotchnikoff S

    更新日期:1995-11-27 00:00:00

  • Temporal prediction restores the evaluative processing of delayed action feedback: an electrophysiological study.

    abstract::The evaluative processing of the valence of action feedback is reflected by an event-related brain potential component called feedback-related negativity (FRN) or reward positivity (RewP). Recent studies have shown that FRN/RewP is markedly reduced when the action-feedback interval is long (e.g. 6000 ms), indicating t...


    pub_type: 杂志文章


    authors: Kimura K,Kimura M

    更新日期:2016-09-28 00:00:00

  • Human amygdala activation detected with echo-planar functional magnetic resonance imaging.

    abstract::Echo-Planar functional magnetic resonance imaging (EP-fMRI) was used to study the activity of the amygdala while three normal female subjects viewed alternating blocks of affectively neutral and affectively negative still pictures. Bilateral activation in the amygdala that was significantly correlated with the changin...


    pub_type: 杂志文章


    authors: Irwin W,Davidson RJ,Lowe MJ,Mock BJ,Sorenson JA,Turski PA

    更新日期:1996-07-29 00:00:00

  • Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs.

    abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...


    pub_type: 杂志文章


    authors: Ghauri M,Chapman AG,Meldrum BS

    更新日期:1996-06-17 00:00:00

  • Pulsed radio frequency radiation affects cognitive performance and the waking electroencephalogram.

    abstract::We investigated the effects of radio frequency electromagnetic fields on brain physiology. Twenty-four healthy young men were exposed for 30 min to pulse-modulated or continuous-wave radio frequency electromagnetic fields (900 MHz; peak specific absorption rate 1 W/kg), or sham exposed. During exposure, participants p...


    pub_type: 临床试验,杂志文章


    authors: Regel SJ,Gottselig JM,Schuderer J,Tinguely G,Rétey JV,Kuster N,Landolt HP,Achermann P

    更新日期:2007-05-28 00:00:00

  • A novel approach for mechanical tissue characterization indicates decreased elastic strength in brain areas affected by experimental thromboembolic stroke.

    abstract::As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...


    pub_type: 杂志文章


    authors: Michalski D,Härtig W,Krueger M,Hobohm C,Käs JA,Fuhs T

    更新日期:2015-07-08 00:00:00

  • Effect of erythropoietin on Fas/FasL expression in brain tissues of neonatal rats with hypoxic-ischemic brain damage.

    abstract::Hypoxic-ischemic brain damage (HIBD) occurs due to intrauterine hypoxia ischemia influencing the energy supply for fetal brain cells, which affects the metabolism of the brain to make the brain suffer a severe damage. Erythropoietin (EPO), which regulates hemacytopoiesis, is a kind of cytokine. EPO is sensitive to hyp...


    pub_type: 杂志文章


    authors: Huang R,Zhang J,Ren C,Zhang X,Gu L,Dong Y,Zhang J,Zhang J

    更新日期:2019-03-06 00:00:00

  • Forebrain activation induced by postoral nutritive substances in rats.

    abstract::Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...


    pub_type: 杂志文章


    authors: Tsurugizawa T,Kondoh T,Torii K

    更新日期:2008-07-16 00:00:00

  • Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.

    abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...


    pub_type: 杂志文章


    authors: Tapia-Arancibia L,André M,Belmar J,Arancibia S

    更新日期:1995-10-02 00:00:00

  • Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retina.

    abstract::GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...


    pub_type: 杂志文章


    authors: Macnab LT,Williams SM,Pow DV

    更新日期:2006-12-18 00:00:00

  • The dissociation of neural circuits in a Stroop task.

    abstract::The Stroop effect refers to an increase in response time observed when the word meaning and the stimulus hue do not match. In an incongruent condition, the word 'green' is presented in the color red, whereas in a congruent condition the word 'red' is presented in the color red. To determine at what level of processing...


    pub_type: 杂志文章


    authors: Xiao X,Qiu J,Zhang Q

    更新日期:2009-05-06 00:00:00

  • Differential distributions of parvalbumin-positive interneurons in the sulci and gyri of the adult ferret cerebral cortex.

    abstract::Although accumulating evidence suggests that there are significant anatomical and histological differences between the sulci and gyri of the cerebral cortex, whether there is a difference in the distribution of interneurons between the two cortical regions remains largely unknown. In this study, we systematically comp...


    pub_type: 杂志文章


    authors: Gao JT,Liu Y,Gong D,Feng XM,Wan P,Luo XF,Zhu WH,Hou JC,Lv SJ

    更新日期:2019-10-16 00:00:00

  • Monoamine neurons in the human brain stem: anatomy, magnetic resonance imaging findings, and clinical implications.

    abstract::By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative an...


    pub_type: 杂志文章,评审


    authors: Sasaki M,Shibata E,Tohyama K,Kudo K,Endoh J,Otsuka K,Sakai A

    更新日期:2008-11-19 00:00:00

  • Novel anticonvulsant action of chronic melatonin in gerbils.

    abstract::Melatonin, a hormone from the pineal gland, was tested for its anticonvulsant effects in male gerbils. Daily administration of melatonin (25 micrograms injection-1, s.c.) for ten weeks reduced the number and severity of seizures (total convulsion score: 7.67 +/- 1.83 in controls vs 2.47 +/- 0.90 in melatonin-injected ...


    pub_type: 杂志文章


    authors: Champney TH,Champney JA

    更新日期:1992-12-01 00:00:00

  • NK1 receptor and the ventral medulla of the rat: bulbospinal and catecholaminergic neurons.

    abstract::Bulbospinal C1 neurons are sympathoexcitatory and excited by substance P. However the substance P receptor (NK1 receptor), has been reported to be absent from the somata of C1 neurons. In this study, using double and triple labelling immunofluorescence and retrograde tracing, we provide evidence that the NK1 receptor ...


    pub_type: 杂志文章


    authors: Makeham JM,Goodchild AK,Pilowsky PM

    更新日期:2001-12-04 00:00:00

  • Continuous theta-burst stimulation over the primary somatosensory cortex modulates interhemispheric inhibition.

    abstract::One mechanism thought to mediate hand and upper limb control across motor cortices is called interhemispheric inhibition (IHI). Somatosensory cortices are important in the motor control of the hand, although the neural mechanisms by which somatic loci act are not fully understood. In the present study, we study the po...


    pub_type: 杂志文章


    authors: Zapallow CM,Jacobs MF,Lee KG,Asmussen MJ,Tsang P,Nelson AJ

    更新日期:2013-05-08 00:00:00

  • Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.

    abstract::We previously reported that clusterin enhances astrocyte proliferation and extracellular signal-regulated kinase (ERK) activity. It, however, remains largely unknown how clusterin promotes cell growth. Here, we investigate the signaling pathway and related molecules underlying astrocyte proliferation by clusterin. Exo...


    pub_type: 杂志文章


    authors: Shim YJ,Shin YJ,Jeong SY,Kang SW,Kim BM,Park IS,Min BH

    更新日期:2009-03-04 00:00:00

  • The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices.

    abstract::Hypoxia-induced changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was ma...


    pub_type: 杂志文章


    authors: Staunton M,Dulitz MG,Fang C,Schmeling WT,Kampine JP,Farber NE

    更新日期:1998-05-11 00:00:00

  • Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury.

    abstract::Activity of calpains and caspase-3 inferred from proteolysis of the cytoskeletal protein alpha-spectrin into signature spectrin breakdown products (SBDPs) was used to provide the first systematic and simultaneous comparison of changes in activity of these two families of cysteine proteases after traumatic brain injury...


    pub_type: 杂志文章


    authors: Pike BR,Zhao X,Newcomb JK,Posmantur RM,Wang KK,Hayes RL

    更新日期:1998-08-03 00:00:00

  • Expression of tPA mRNA in the facial nucleus following facial nerve transection in the rat.

    abstract::Plasminogen activators (PAs) have been suggested to play a role in neuronal migration and glial cell proliferation in the developing CNS. Less is known, however, about the role of PAs in the mature nervous system. To elucidate the role of tissue type plasminogen activator (tPA) in the nervous system we used in situ hy...


    pub_type: 杂志文章


    authors: Yuguchi T,Kohmura E,Yamada K,Otsuki H,Sakaki T,Yamashita T,Nonaka M,Sakaguchi T,Wanaka A,Hayakawa T

    更新日期:1997-01-20 00:00:00

  • Role of amygdala in conditioned and unconditioned fear generated in the periaqueductal gray.

    abstract::The amygdala and ventral portion of the periaqueductal gray (vPAG) are crucial for the expression of the contextual freezing behavior. However, it is still unclear whether the amygdala also plays a role in defensive behaviors induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present st...


    pub_type: 杂志文章


    authors: Oliveira LC,Nobre MJ,Brandão ML,Landeira-Fernandez J

    更新日期:2004-10-05 00:00:00

  • Selective interference reveals dissociation between memory for location and colour.

    abstract::The aim was to study whether there is indication of a dissociation in processing of visuospatial and colour information in working memory in humans. Experimental subjects performed visuospatial and colour n-back tasks with and without visuospatial and colour distractive stimuli presented in the middle of the delay per...


    pub_type: 杂志文章


    authors: Vuontela V,Rämä P,Raninen A,Aronen HJ,Carlson S

    更新日期:1999-08-02 00:00:00

  • Improvement in γ-hydroxybutyrate-induced contextual fear memory deficit by systemic administration of NCS-382.

    abstract::Low, nonsedative doses of γ-hydroxybutyric acid (GHB) produce short-term anterograde amnesia in humans and memory impairments in experimental animals. We have previously shown that acute systemic treatment of GHB in adolescent female rats impairs the acquisition, but not the expression, of contextual fear memory while...


    pub_type: 杂志文章


    authors: Ishiwari K,Sircar R

    更新日期:2016-06-15 00:00:00

  • Olfactory bulb DA receptors may be located on terminals of the olfactory nerve.

    abstract::The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distribute...


    pub_type: 杂志文章


    authors: Nickell WT,Norman AB,Wyatt LM,Shipley MT

    更新日期:1991-01-01 00:00:00

  • Induction of ischemic tolerance and antioxidant activity by brief focal ischemia.

    abstract::Three forms of non-injurious ischemic preconditioning were tested for their effects on endogenous antioxidant activity and subsequent ischemic injury. Test ischemia alone, consisting of 1 h occlusion of both carotid arteries (BCAs) and one middle cerebral artery (MCA), elicited an average volume of cerebral infarction...


    pub_type: 杂志文章


    authors: Toyoda T,Kassell NF,Lee KS

    更新日期:1997-03-03 00:00:00

  • Antigens of monoclonal antibody NB3C4 are novel markers for oligodendrocytes.

    abstract::We produced NB3C4, a novel monoclonal antibody specific for oligodendrocytes, using human neuroblastoma IMR-32 cells. NB3C4 specifically recognized oligodendrocytes in the CNS, although it bound to neuroblastoma IMR-32 cells and oligodendrocytes in vitro. Double immunofluorescence staining of rat brain using NB3C4 and...


    pub_type: 杂志文章


    authors: Yoshimura K,Kametani F,Shimoda Y,Fujimaki K,Sakurai Y,Kitamura K,Asou H,Nomura M

    更新日期:2001-02-12 00:00:00

  • Event-related potentials for interaural time differences and spectral cues.

    abstract::Dichotic pitches and mistuned harmonics can each lead to the perception of one or two auditory objects. Comparison of event-related potentials for the perception of one versus two objects reveals an early negative and a late positive component. The relationship of these components with auditory segregation was further...


    pub_type: 杂志文章


    authors: Hautus MJ,Johnson BW,Colling LJ

    更新日期:2009-07-01 00:00:00

  • Effects of MPSS and a potent iNOS inhibitor on traumatic spinal cord injury.

    abstract::ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolo...


    pub_type: 杂志文章


    authors: Yu Y,Matsuyama Y,Nakashima S,Yanase M,Kiuchi K,Ishiguro N

    更新日期:2004-09-15 00:00:00

  • Long-term disuse of the hand affects motor imagery ability in patients with complete brachial plexus palsy.

    abstract::The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...


    pub_type: 杂志文章


    authors: Date S,Kurumadani H,Yoshimura M,Fukae A,Onishi K,Hayashi J,Shinomiya R,Sunagawa T

    更新日期:2019-04-10 00:00:00